Detalhes bibliográficos
| Ano de defesa: |
2016 |
| Autor(a) principal: |
Ravski, Leandro Aparecido
 |
| Orientador(a): |
Vellosa, José Carlos Rebuglio
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| Banca de defesa: |
Khalil, Omar Arafat Kdudsi
,
Scomparin, Dionizia Xavier
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| Tipo de documento: |
Dissertação
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| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
UNIVERSIDADE ESTADUAL DE PONTA GROSSA
|
| Programa de Pós-Graduação: |
Programa de Pós Graduação Ciências Farmacêuticas
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| Departamento: |
Farmacos, Medicamentos e Biociências Aplicadas à Farmácia
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| País: |
BR
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| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://tede2.uepg.br/jspui/handle/prefix/94
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Resumo: |
Pneumonia is an acute disease characterized by inflammation of the lung parenchyma tissue.It is a respiratory disease with the highest incidence in the world. There are approximately 150 million cases in children under 5 years each year, and approximately 2 million result in death. In pneumonia, the damage to the lung tissue occurs due to the release of reactive oxygen species, causing increased oxidative stress due to the formation of free radicals. In the search for new alternatives to assist in the diagnosis of pneumonia, the assessment of possible variations in intracranial pressure (ICP) compared to pulmonary infection can be of great importance. Researchers have developed a new ICP measurement system completely noninvasive,which changed the course of history of neuroscience. This work aims to bring new data to the scientific community, characterizing normal PIC waves to a group of healthy children and investigating possible changes in children diagnosed with pneumonia. This study included 96 volunteers, divided into two groups: Test (hospitalized children diagnosed with pneumonia) and control (healthy children). There was the realization of the following laboratory tests: blood count, biochemical tests, inflammatory markers, serum total antioxidant capacity and catalase activity. In addition to the completion of the ICP monitoring with the use of new non-invasive technology. There was a significant increase in blood glucose, the inflammatory parameters in hematological parameters (total leukocytes, neutrophils, rods and targeted) and total serum antioxidant capacity of the test group. Urea, creatinine, total protein, albumin, total cholesterol, HDL, LDL, hemoglobin and hematocrit were significantly decreased in the test group. Although there was no statistical difference between the groups in terms of PIC. Our study showed the PIC's behavior in children, identifying changes in both groups, showing no direct relationship with pneumonia. This study served to introduce this innovative monitoring unit pic completely non-invasive, which has revolutionized the neuromedicina without the need for trepanation of the skull, can now be studied without any population risks to volunteer study. |
