Efeito da proteína HSP70 de Mycobacterium tuberculosis na resposta pulmonar alérgica em camundongos

• Ano de defesa: 2012
• Autor(a) principal: Barbosa, Gustavo Leivas
• Orientador(a): Pitrez, Paulo Márcio Condessa
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul
• Programa de Pós-Graduação: Programa de Pós-Graduação em Medicina/Pediatria e Saúde da Criança
• Departamento: Faculdade de Medicina
• País: BR
• Palavras-chave em Português: MEDICINA; PEDIATRIA; ASMA; PROTEÍNAS DO CHOQUE TÉRMICO; RATOS - EXPERIÊNCIAS
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::PEDIATRIA
• Link de acesso: http://tede2.pucrs.br/tede2/handle/tede/1399

Introduction: Heat shock proteins like mycobacterial HSP70 has a protective and anti-inflamatory activity in several animals models diseases, like arthritis and skin allograft. This protein can modulates both the innate and adaptative immune system. Objective: The aim of this study was evaluate the effect of HSP70 from M. tuberculosis on development of pulmonary allergic reponse in a mice model. Methods: Female BALBc mice with ovalbumin induced pulmonary disease received intraperitoneal inject or intranasal instillation of mycobacterium HSP70. Treg cell in lung tissue, inflammatory cells profiles and cytokines levels in broncalveolar lavage fluid was measured. Results: HSP70 show an inhibitory effect on pulmonary allergic response on mice. Eosinophils, IL-5 and IFN- levels was reduced in broncoalveolar lavage fluid in animals that received intranasal instillation of mycobacterial HSP70. Conclusion: Mycobacterial HSP70 can be efficiently used to treat airway allergic disorders.