Detalhes bibliográficos
| Ano de defesa: |
2014 |
| Autor(a) principal: |
Santos, Fabiana Gonçalves dos
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| Orientador(a): |
Ligabue, Rosane Angélica
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| Banca de defesa: |
Não Informado pela instituição |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Pontifícia Universidade Católica do Rio Grande do Sul
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| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Engenharia e Tecnologia de Materiais
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| Departamento: |
Faculdade de Engenharia
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| País: |
BR
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| Palavras-chave em Português: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://tede2.pucrs.br/tede2/handle/tede/3250
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Resumo: |
Searches in nanotechnology allied to studies of biopolymers advances for application in the medical / pharmaceutical field. Micro / nanoparticles (NP) with biodegradable polymer systems are promising for the controlled release of drugs in the form of nanocapsules (NC) or nanospheres (NS), able to protect / release the substance gradually. This work aims to prepare NP polyurethane (Mw = 224,973 g/ mol and Mn = 134 670 g / mol) for the encapsulation by multiple emulsion of the pharmaco α-tocopherol (α-TOC) with and without açai oil and different stirring techniques (ultra-turrax (TR) and ultrasound (SM)), as well as the study of controlled release in physiological medium. The average sizes of the obtained NP were between 600 nm and 10 μm using the SM and between 2-15 μm using the TR and all presented spherical morphology and variables distributions depending on the presence or absence of açai oil. It was also possible to detect the presence of α-TOC and açai oil (when present) in all NP's, as well as the degradation of PU and release of α-TOC through the techniques of UV-Vis, IR and TGA. The encapsulation efficiency of α-TOC was moderate, ranging between 15-34% for NPs obtained by TR and between 18-44% for NPs obtained by SM, due to the affinity of the hydrophobic compound with the PU. The amount of α-TOC initially added in the formulations obtained high rates of recovery ranging from 93-96%. The NPs showed a mass loss of less than 4% when exposed to hydrolytic degradation up to 30 days. The ultraturrax samples without açai oil and ultrasound with açai oil showed increased release of α-TOC from the 12th day, whereas NP's ultra-turrax with açai oil and ultrasound without acai oil showed constant release up to day 30. The results indicate that the presence of oil using the MS showed more efficiency in the formation of NPs |
