Síntese e caracterização de poliuretano ramificado com potencial aplicação em engenharia de tecidos

Detalhes bibliográficos
Ano de defesa: 2016
Autor(a) principal: Hoffmann, Mauricio da Silva lattes
Orientador(a): Ligabue, Rosane Angélica lattes
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul
Programa de Pós-Graduação: Programa de Pós-Graduação em Engenharia e Tecnologia de Materiais
Departamento: Faculdade de Engenharia
País: Brasil
Palavras-chave em Português:
Área do conhecimento CNPq:
Link de acesso: http://tede2.pucrs.br/tede2/handle/tede/6853
Resumo: Polyurethanes (PU) are widely used as biomaterials because it has good compatibility, and desirable mechanical properties and branched polyurethanes have shown besides these characteristics, an appreciable stability to hydrolytic and enzymatic degradation. Within this context, this study aimed to synthesize branched polyurethanes from the addition of pentaerythritol and evaluate its potential use as scaffolds in tissue engineering. Polycaprolactone diol (PCL) as polyol and pentaerythritol (PETT) in different amounts (5, 10 and 15% w/w relative to the polyol) as well as the hexamethylene diisocyanate (HDI) were used in the synthesis of the branched PU. These branched PU (PU-PETT) were evaluated for structural, morphological, mechanical, thermal and solubility in various organic solvents and compared to the linear PU (without PETT). Among the branched PU, PU-PETT 5% showed better morphological and tensile strength characteristics, so it was used to prepare membranes leached with the linear PU. The leached membranes were evaluated for their structural, morphological, mechanical, thermal properties, wettability, hydrolytic degradation, calcification and swelling degree. The leached membrane PU-PETT 5% showed high porosity and interconnectivity, greater thermal stability compared to linear PU leached membrane, despite the lower degree of crystallinity and molar weight. Also, the PU-PETT 5% membrane exhibited the ability of calcium phosphate biomineralization, good wettability, higher stability hydrolytic degradation and greater swelling as compared to linear PU membrane. Thus, it can be concluded that the membrane PU-PETT 5% exhibited characteristics suitable for use as biomaterials in tissue engineering.