Associação entre elastografia e doppler na avaliação de transplantes renais

• Ano de defesa: 2020
• Autor(a) principal: Gonçalves, Luana Marinho
• Orientador(a): Hochhegger, Bruno
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul
• Programa de Pós-Graduação: Programa de Pós-Graduação em Medicina e Ciências da Saúde
• Departamento: Escola de Medicina
• País: Brasil
• Palavras-chave em Português: Transplante de Rim; Técnicas de Imagem por Elasticidade; Efeito Doppler
• Palavras-chave em Inglês: Kidney Transplantation; Elasticity Imaging Techniques; Doppler Effect
• Área do conhecimento CNPq: CIENCIAS DA SAUDE::MEDICINA
• Link de acesso: http://tede2.pucrs.br/tede2/handle/tede/9302

Background. Shear wave elastography is a noninvasive imaging modality for quantitative assessment of tissue stiffness. Objective: to evaluate the association between shear wave elastography parameters and renal alteration by color Doppler in renal transplant patients. Methods: prospective cross-sectional study. Renal transplant patients followed in the Nephrology Service, aged over 18 years and with indication for ultrasound. Multivariate analysis was performed using Binary Logistic Regression by Generalized Linear Models to identify the independent variables associated with the Doppler resistance index. Results. We evaluated 57 patients treated in the Nephrology Outpatient Clinic. The mean age of the patients was 47 ± 16.4 years, 40 (70.2%) males and 46 (80.7%) self-reported as white. The medians of glomerular filtration rate and creatinine were respectively 15.6 (7.8 - 28.3) and 3.57 (2.2 - 6.0) μmol / l. There was a high prevalence of patients with severe to terminal renal function (n = 41, 72%). The average kidney was 11.7 ± 1.5cm. Most of the evaluated patients received deceased donor kidney (n = 54, 94.7%). The results of the analysis of agecontrolled generalized linear models (OR 1.377, 95% CI 1.182 to 1.603; p <0.001) identified the parameters of elastography, velocity and resistance (OR = 17.12, 95% CI 1.137 to 257.83), p = 0.040 and OR 1.204, 95% CI 1.020 to 1.422, p = 0.028, respectively) as independent factors associated with renal impairment. Conclusion. The parameters of elastography, velocity and resistance, when adjusted for age, showed a positive association with renal alteration, assessed by color Doppler.