Midazolam intramuscular versus Diazepam endovenoso no tratamento da crise convulsiva em emergência pediátrica

• Ano de defesa: 2011
• Autor(a) principal: Portela, Janete de Lourdes
• Orientador(a): Piva, Jefferson Pedro
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul; Porto Alegre
• Palavras-chave em Português: MEDICINA; PEDIATRIA; EPILEPSIA; CONVULSÕES; EMERGÊNCIAS; DIAZEPAN - USO TERAPÊUTICO; MIDAZOLAM; ANTICONVULSIVOS; INJEÇÕES ENDOVENOSAS; INJEÇÕES INTRAMUSCULARES
• Link de acesso: http://hdl.handle.net/10923/4712

Objective : compare the therapeutic efficacy of intramuscular midazolam (IM-MDZ) and intravenous diazepam (IV-DZP) to 529treat seizures in children. Methods : Randomized controlled study enrolling children (2months-14years) presenting seizures admitted to the Pediatric Emergency Department of the Hospital Universitário de Santa Maria between August 2010-August 2011; being randomized to receive IV-DZP or IM-MDZ as initial treatment. The groups were compared regarding the length of time to start medication, to interrupt seizures after being medicated and the total length of time to achieve the seizures interruption. Results : Venous access was not obtained in 4 minutes in 4 patients (20%) assigned to the IV-DZP. 32 children completed the study (16 in each group). IV-DZP compared to the IM-MDZ, presented the longest interval to cease seizures (10. 6 x 7. 3min; p=0. 006). Two children of each group (12. 5%) the seizures did not stop after 10 minutes, being 3 children transferred to the PICU after tracheal intubation: 1 belonging to the IM-MDZ (6. 25%0 and 2 in the IV-DZP group (12. 5%). There were not differences regarding adverse effects between the groups (p=0. 171): one child in the IM-MDZ presented hypotension (6. 3%) and 5 (31%) presented hyperactivity or vomit after receiving IV-DZP. Conclusion : Intramuscular midazolam presented lower interval to cease seizures than IV diazepam. Intrauscular midazolam demonstrate be ans excellent o treat seizures in children as a result of its efficacy, facility and fast administration.