Efeito de vernizes contendo Xilitol na remineralização do esmalte de dentes decíduos: estudo in vitro.

• Ano de defesa: 2019
• Autor(a) principal: Barreto, Gabriela Santos
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Cruzeiro do Sul; Brasil; Campus Liberdade; Mestrado em Odontologia; Cruzeiro do Sul
• Palavras-chave em Português: Xilitol; Cárie dentária; Flúor; Biofilme dentário; CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
• Link de acesso: https://repositorio.cruzeirodosul.edu.br/handle/123456789/357

Xylitol, a substitute for sugars, has been highlighted in recent years as a sweetener in products intended to improve oral health due to its bacteriostatic, anticariogenic and remineralizing properties. Primary teeth are known to have characteristics that make them more susceptible to carious lesions compared to permanent teeth. Considering that the varnish containing sodium fluoride is a strategy widely used in dentistry for the purpose of controlling dental caries, the objective of the present in vitro study was to evaluate the remineralization of primary human enamel after the application of a varnish containing xylitol, with different particle sizes (146 and 80μm). The surface microhardness was performed on 56 specimens of primary molar enamel (3x3 mm) and they were submitted to artificial caries lesion formation (Buskes' solution, 11 days). The specimens were randomized into 4 groups (n = 14) and treated with the varnishes: 20% xylitol, 20% xylitol milled; Duraphat® (5% NaF) and placebo varnish (without F or xylitol). Xylitol particles of the group "20% xylitol milled" were subjected to a ball mill for 60 minutes with a frequency of 10 Hz, in order to decrease the precipitation of the particles in the varnish. The varnishes were applied and removed after 6 h of immersion in artificial saliva, submitted to pH cycling (demineralization-2h / remineralization-22h per day, 8 days) and, at the end, the surface hardness, the percentage of surface hardness recovery (% RDS), as well as subsurface hardness and integrated mineral loss (ΔKHN) were evaluated. Data were analyzed statistically by the Kruskal-Wallis and Tukey tests (p˂0.05). The values of %SHR were significantly higher for the experimental varnishes containing xylitol and the gold standard varnish when compared to the placebo varnish, and did not differ significantly between them. Regarding the integrated mineral loss, the experimental and commercial varnishes showed significantly lower lesion areas compared to the placebo varnish, not differing from each other. Reducing the size of xylitol particles by 45% (ground xylitol) decreased their decantation in the experimental varnish, influencing the remineralizing capacity of the material. The milled xylitol was the only one capable of promoting a superior remineralization significantly different from the placebo varnish in the deeper layer of the enamel (50 μm). It can be concluded that xylitol varnishes appears to be promising alternatives in promoting remineralization of primary tooth enamel, both on the surface and subsurface of white spot lesions.