Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice

Detalhes bibliográficos
Autor(a) principal: Higa, Roberta Alves
Data de Publicação: 2011
Outros Autores: Aydos, Ricardo Dutra, Silva, Iandara Schettert, Ramalho, Rondon Tosta, Souza, Albert Schiaveto de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMS
DOI: http://dx.doi.org/10.1590/S0102-86502011000200009.
Texto Completo: https://repositorio.ufms.br/handle/123456789/1271
http://dx.doi.org/10.1590/S0102-86502011000200009.
Resumo: OBJETIVO: Estudar a ação antitumoral da Tabebuia avellanedae (Ipê-Roxo) na carcinogênese colônica induzida experimentalmente pelo azoximetano em camundongos. MÉTODOS: Foram utilizados 50 camundongos divididos em 5 grupos: grupo I administrado Azoximetano (AOM); grupo II - β-lapachona; grupo III - veículo (diluente); grupo IV - veículo + AOM; e grupo V - β-lapachona + AOM. RESULTADOS: Observou-se presença de focos de criptas aberrantes em todos os animais dos grupos I e IV, 50% no grupo II e 90% no grupo V. CONCLUSÃO: A β-lapachona extraída da Tabebuia avellanedae não apresentou efeito protetor das lesões induzidas pelo azoximetano em cólon de camundongos.
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spelling 2012-04-18T18:56:01Z2021-09-30T19:55:45Z2011-04HIGA, Roberta Alves et al . Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice. Acta Cir. Bras., São Paulo, v. 26, n. 2, Apr. 2011 . Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000200009&lng=en&nrm=iso>. access on 18 Apr. 2012.https://repositorio.ufms.br/handle/123456789/1271http://dx.doi.org/10.1590/S0102-86502011000200009.OBJETIVO: Estudar a ação antitumoral da Tabebuia avellanedae (Ipê-Roxo) na carcinogênese colônica induzida experimentalmente pelo azoximetano em camundongos. MÉTODOS: Foram utilizados 50 camundongos divididos em 5 grupos: grupo I administrado Azoximetano (AOM); grupo II - β-lapachona; grupo III - veículo (diluente); grupo IV - veículo + AOM; e grupo V - β-lapachona + AOM. RESULTADOS: Observou-se presença de focos de criptas aberrantes em todos os animais dos grupos I e IV, 50% no grupo II e 90% no grupo V. CONCLUSÃO: A β-lapachona extraída da Tabebuia avellanedae não apresentou efeito protetor das lesões induzidas pelo azoximetano em cólon de camundongos.ABSTRACT - PURPOSE: To study the antitumor action of Tabebuia avellanedae in experimentally induced colon carcinogenesis by azoxymethane in mice. METHODS: Fifty (n=50) mice were divided into five groups: in group I azoxymethane (AOM) was administered, in Group II - β-lapachone, in group III - vehicle (diluent) and in group IV - vehicle + AOM and finally in group V - β-lapachone + AOM. RESULTS: It was observed the presence of aberrant crypt foci in all animals of groups I and IV, 50% in group II and 90% in group V. CONCLUSION: The β-lapachone extracted from the Tabebuia avellanedae showed no protective effect of lesions induced by azoxymethane in colon of mice.engActa Cirurgica BrasileiraCarcinógenosNeoplasias ColorretaisAzoximetanoTabebuiaNaftoquinonasCamundongosCarcinogensColorectal NeoplasmsAzoxymethaneTabebuiaNaphthoquinonesMiceStudy of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in miceEstudo da ação antineoplásica da Tabebuia avellanedae (Ipê-Roxo) na carcinogênese induzida pelo azoximetano em camundongosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHiga, Roberta AlvesAydos, Ricardo DutraSilva, Iandara SchettertRamalho, Rondon TostaSouza, Albert Schiaveto deinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMSinstname:Universidade Federal de Mato Grosso do Sul (UFMS)instacron:UFMSTHUMBNAILStudy of the antineoplastic action of Tabebuia.pdf.jpgStudy of the antineoplastic action of Tabebuia.pdf.jpgGenerated Thumbnailimage/jpeg1447https://repositorio.ufms.br/bitstream/123456789/1271/4/Study%20of%20the%20antineoplastic%20action%20of%20Tabebuia.pdf.jpgdc70c682f2db07aa2e1bb8a01b7150feMD54ORIGINALStudy of the antineoplastic action of Tabebuia.pdfStudy of the antineoplastic action of Tabebuia.pdfapplication/pdf223377https://repositorio.ufms.br/bitstream/123456789/1271/1/Study%20of%20the%20antineoplastic%20action%20of%20Tabebuia.pdf344f95c73290d929dfaea36b9d9dcce0MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufms.br/bitstream/123456789/1271/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTStudy of the antineoplastic action of Tabebuia.pdf.txtStudy of the antineoplastic action of Tabebuia.pdf.txtExtracted texttext/plain18911https://repositorio.ufms.br/bitstream/123456789/1271/3/Study%20of%20the%20antineoplastic%20action%20of%20Tabebuia.pdf.txt356263a6657baaf5de635f17d9f9dc20MD53123456789/12712021-09-30 15:55:45.328oai:repositorio.ufms.br:123456789/1271Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://repositorio.ufms.br/oai/requestri.prograd@ufms.bropendoar:21242021-09-30T19:55:45Repositório Institucional da UFMS - Universidade Federal de Mato Grosso do Sul (UFMS)false
dc.title.pt_BR.fl_str_mv Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
dc.title.alternative.pt_BR.fl_str_mv Estudo da ação antineoplásica da Tabebuia avellanedae (Ipê-Roxo) na carcinogênese induzida pelo azoximetano em camundongos
title Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
spellingShingle Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
Higa, Roberta Alves
Carcinógenos
Neoplasias Colorretais
Azoximetano
Tabebuia
Naftoquinonas
Camundongos
Carcinogens
Colorectal Neoplasms
Azoxymethane
Tabebuia
Naphthoquinones
Mice
title_short Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
title_full Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
title_fullStr Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
title_full_unstemmed Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
title_sort Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
author Higa, Roberta Alves
author_facet Higa, Roberta Alves
Aydos, Ricardo Dutra
Silva, Iandara Schettert
Ramalho, Rondon Tosta
Souza, Albert Schiaveto de
author_role author
author2 Aydos, Ricardo Dutra
Silva, Iandara Schettert
Ramalho, Rondon Tosta
Souza, Albert Schiaveto de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Higa, Roberta Alves
Aydos, Ricardo Dutra
Silva, Iandara Schettert
Ramalho, Rondon Tosta
Souza, Albert Schiaveto de
dc.subject.por.fl_str_mv Carcinógenos
Neoplasias Colorretais
Azoximetano
Tabebuia
Naftoquinonas
Camundongos
Carcinogens
Colorectal Neoplasms
Azoxymethane
Tabebuia
Naphthoquinones
Mice
topic Carcinógenos
Neoplasias Colorretais
Azoximetano
Tabebuia
Naftoquinonas
Camundongos
Carcinogens
Colorectal Neoplasms
Azoxymethane
Tabebuia
Naphthoquinones
Mice
description OBJETIVO: Estudar a ação antitumoral da Tabebuia avellanedae (Ipê-Roxo) na carcinogênese colônica induzida experimentalmente pelo azoximetano em camundongos. MÉTODOS: Foram utilizados 50 camundongos divididos em 5 grupos: grupo I administrado Azoximetano (AOM); grupo II - β-lapachona; grupo III - veículo (diluente); grupo IV - veículo + AOM; e grupo V - β-lapachona + AOM. RESULTADOS: Observou-se presença de focos de criptas aberrantes em todos os animais dos grupos I e IV, 50% no grupo II e 90% no grupo V. CONCLUSÃO: A β-lapachona extraída da Tabebuia avellanedae não apresentou efeito protetor das lesões induzidas pelo azoximetano em cólon de camundongos.
publishDate 2011
dc.date.issued.fl_str_mv 2011-04
dc.date.accessioned.fl_str_mv 2012-04-18T18:56:01Z
dc.date.available.fl_str_mv 2021-09-30T19:55:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv HIGA, Roberta Alves et al . Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice. Acta Cir. Bras., São Paulo, v. 26, n. 2, Apr. 2011 . Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000200009&lng=en&nrm=iso>. access on 18 Apr. 2012.
dc.identifier.uri.fl_str_mv https://repositorio.ufms.br/handle/123456789/1271
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1590/S0102-86502011000200009.
identifier_str_mv HIGA, Roberta Alves et al . Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice. Acta Cir. Bras., São Paulo, v. 26, n. 2, Apr. 2011 . Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000200009&lng=en&nrm=iso>. access on 18 Apr. 2012.
url https://repositorio.ufms.br/handle/123456789/1271
http://dx.doi.org/10.1590/S0102-86502011000200009.
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dc.publisher.none.fl_str_mv Acta Cirurgica Brasileira
publisher.none.fl_str_mv Acta Cirurgica Brasileira
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