Review of structural features and binding capacity of polyphenols to gluten proteins and peptides in vitro: Relevance to celiac disease

Bibliographic Details
Main Author: Ribeiro, Miguel
Publication Date: 2020
Other Authors: de Sousa, Telma, Poeta, Patrícia, Bagulho, Ana Sofia, Igrejas, Gilberto
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/120624
Summary: UIDB 50006/2020 UID/AGR/04033/2019 project-POCI-01-0145-FEDER-029068
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network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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spelling Review of structural features and binding capacity of polyphenols to gluten proteins and peptides in vitro: Relevance to celiac diseaseAdjuvant therapyCeliac diseaseGlutenPolyphenolsBiochemistryPhysiologyMolecular BiologyClinical BiochemistryCell BiologySDG 3 - Good Health and Well-beingUIDB 50006/2020 UID/AGR/04033/2019 project-POCI-01-0145-FEDER-029068Polyphenols have been extensively studied due to their beneficial effects on human health, particularly for the prevention and treatment of diseases related to oxidative stress. Nevertheless, they are also known to have an anti-nutritional effect in relation to protein metabolism. This effect is a consequence of its binding to digestive enzymes and/or protein substrates. Dietary gluten is the main trigger of celiac disease, a common immune-based disease of the small intestine and for which the only treatment available is the adherence to a gluten-free diet. Recent studies have addressed the use of dietary polyphenols to interact with gluten proteins and avoid its downstream deleterious effects, taking the advantage of the anti-nutritive nature of polyphenols by protein sequestering. Flavonoids, coumarins and tannins have shown the ability to form insoluble complexes with gluten proteins. One of the most promising molecules has been epigallocatechin-3-gallate, which through its binding to gliadins, was able to reduce gliadins digestibility and its ability to stimulate monolayer permeability and transepithelial transport of immunodominant peptides in cell models. This review focuses on the structural features and binding capacity of polyphenols to gluten proteins and peptides, and the prospects of developing an adjuvant therapy in celiac disease.LAQV@REQUIMTERUNRibeiro, Miguelde Sousa, TelmaPoeta, PatríciaBagulho, Ana SofiaIgrejas, Gilberto2021-07-06T22:18:25Z2020-062020-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/120624eng2076-3921PURE: 32381871https://doi.org/10.3390/antiox9060463info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:54:28Zoai:run.unl.pt:10362/120624Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:25:22.263462Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Review of structural features and binding capacity of polyphenols to gluten proteins and peptides in vitro: Relevance to celiac disease
title Review of structural features and binding capacity of polyphenols to gluten proteins and peptides in vitro: Relevance to celiac disease
spellingShingle Review of structural features and binding capacity of polyphenols to gluten proteins and peptides in vitro: Relevance to celiac disease
Ribeiro, Miguel
Adjuvant therapy
Celiac disease
Gluten
Polyphenols
Biochemistry
Physiology
Molecular Biology
Clinical Biochemistry
Cell Biology
SDG 3 - Good Health and Well-being
title_short Review of structural features and binding capacity of polyphenols to gluten proteins and peptides in vitro: Relevance to celiac disease
title_full Review of structural features and binding capacity of polyphenols to gluten proteins and peptides in vitro: Relevance to celiac disease
title_fullStr Review of structural features and binding capacity of polyphenols to gluten proteins and peptides in vitro: Relevance to celiac disease
title_full_unstemmed Review of structural features and binding capacity of polyphenols to gluten proteins and peptides in vitro: Relevance to celiac disease
title_sort Review of structural features and binding capacity of polyphenols to gluten proteins and peptides in vitro: Relevance to celiac disease
author Ribeiro, Miguel
author_facet Ribeiro, Miguel
de Sousa, Telma
Poeta, Patrícia
Bagulho, Ana Sofia
Igrejas, Gilberto
author_role author
author2 de Sousa, Telma
Poeta, Patrícia
Bagulho, Ana Sofia
Igrejas, Gilberto
author2_role author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Ribeiro, Miguel
de Sousa, Telma
Poeta, Patrícia
Bagulho, Ana Sofia
Igrejas, Gilberto
dc.subject.por.fl_str_mv Adjuvant therapy
Celiac disease
Gluten
Polyphenols
Biochemistry
Physiology
Molecular Biology
Clinical Biochemistry
Cell Biology
SDG 3 - Good Health and Well-being
topic Adjuvant therapy
Celiac disease
Gluten
Polyphenols
Biochemistry
Physiology
Molecular Biology
Clinical Biochemistry
Cell Biology
SDG 3 - Good Health and Well-being
description UIDB 50006/2020 UID/AGR/04033/2019 project-POCI-01-0145-FEDER-029068
publishDate 2020
dc.date.none.fl_str_mv 2020-06
2020-06-01T00:00:00Z
2021-07-06T22:18:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/120624
url http://hdl.handle.net/10362/120624
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2076-3921
PURE: 32381871
https://doi.org/10.3390/antiox9060463
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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