Meta-research metrics matter : letter regarding article “indirect tolerability comparison of Deutetrabenazine and Tetrabenazine for Huntington disease”

Bibliographic Details
Main Author: Rodrigues, Filipe Brogueira
Publication Date: 2017
Other Authors: Duarte, Gonçalo Silva, Costa, João, Ferreira, Joaquim J, Wild, Edward J.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/33088
Summary: © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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oai_identifier_str oai:repositorio.ulisboa.pt:10451/33088
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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spelling Meta-research metrics matter : letter regarding article “indirect tolerability comparison of Deutetrabenazine and Tetrabenazine for Huntington disease”Huntington’s diseaseTetrabenazineDeutratrabenazineIndirect treatment comparison© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Here we discuss the report by Claassen and colleagues describing an indirect treatment comparison between tetrabenazine and deutetrabenazine for chorea in Huntington's disease using individual patient data. We note the potential for discrepancies in apparently statistically significant findings, due to the rank reversal phenomenon. We provide some cautionary observations and suggestions concerning the limitations of indirect comparisons and the low likelihood that good quality evidence will become available to guide clinical decision comparing these two agents.BioMed CentralRepositório da Universidade de LisboaRodrigues, Filipe BrogueiraDuarte, Gonçalo SilvaCosta, JoãoFerreira, Joaquim JWild, Edward J.2018-05-03T11:43:42Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/33088engJournal of Clinical Movement Disorders (2017) 4:192054-707210.1186/s40734-017-0067-xinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T13:53:39Zoai:repositorio.ulisboa.pt:10451/33088Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T02:57:30.132156Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Meta-research metrics matter : letter regarding article “indirect tolerability comparison of Deutetrabenazine and Tetrabenazine for Huntington disease”
title Meta-research metrics matter : letter regarding article “indirect tolerability comparison of Deutetrabenazine and Tetrabenazine for Huntington disease”
spellingShingle Meta-research metrics matter : letter regarding article “indirect tolerability comparison of Deutetrabenazine and Tetrabenazine for Huntington disease”
Rodrigues, Filipe Brogueira
Huntington’s disease
Tetrabenazine
Deutratrabenazine
Indirect treatment comparison
title_short Meta-research metrics matter : letter regarding article “indirect tolerability comparison of Deutetrabenazine and Tetrabenazine for Huntington disease”
title_full Meta-research metrics matter : letter regarding article “indirect tolerability comparison of Deutetrabenazine and Tetrabenazine for Huntington disease”
title_fullStr Meta-research metrics matter : letter regarding article “indirect tolerability comparison of Deutetrabenazine and Tetrabenazine for Huntington disease”
title_full_unstemmed Meta-research metrics matter : letter regarding article “indirect tolerability comparison of Deutetrabenazine and Tetrabenazine for Huntington disease”
title_sort Meta-research metrics matter : letter regarding article “indirect tolerability comparison of Deutetrabenazine and Tetrabenazine for Huntington disease”
author Rodrigues, Filipe Brogueira
author_facet Rodrigues, Filipe Brogueira
Duarte, Gonçalo Silva
Costa, João
Ferreira, Joaquim J
Wild, Edward J.
author_role author
author2 Duarte, Gonçalo Silva
Costa, João
Ferreira, Joaquim J
Wild, Edward J.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Rodrigues, Filipe Brogueira
Duarte, Gonçalo Silva
Costa, João
Ferreira, Joaquim J
Wild, Edward J.
dc.subject.por.fl_str_mv Huntington’s disease
Tetrabenazine
Deutratrabenazine
Indirect treatment comparison
topic Huntington’s disease
Tetrabenazine
Deutratrabenazine
Indirect treatment comparison
description © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2018-05-03T11:43:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/33088
url http://hdl.handle.net/10451/33088
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Clinical Movement Disorders (2017) 4:19
2054-7072
10.1186/s40734-017-0067-x
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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