Tetrabenazine versus deutetrabenazine for Huntington's disease : twins or distant cousins?

Bibliographic Details
Main Author: Rodrigues, Filipe Brogueira
Publication Date: 2017
Other Authors: Duarte, Gonçalo Silva, Costa, João, Ferreira, Joaquim J, Wild, Edward J.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/33258
Summary: © 2017 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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spelling Tetrabenazine versus deutetrabenazine for Huntington's disease : twins or distant cousins?DeutetrabenazineHuntington's diseaseIndirect comparisonMeta‐analysisTetrabenazine© 2017 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Background: Tetrabenazine is the only US Food and Drug Administration‐approved drug for Huntington's disease, and deutetrabenazine was recently tested against placebo. A switching‐trial from tetrabenazine to deutetrabenazine is underway, but no head‐to‐head, blinded, randomized controlled trial is planned. Using meta‐analytical methodology, the authors compared these molecules. Methods: RCTs comparing tetrabenazine or deutetrabenazine with placebo in Huntington's disease were searched. The authors assessed the Cochrane risk‐of‐bias tool, calculated indirect treatment comparisons, and applied the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework. Results: The evidence network for this report comprised 1 tetrabenazine trial and 1 deutetrabenazine trial, both against placebo. Risk of bias was moderate in both. Participants in the tetrabenazine and deutetrabenazine trials did not differ significantly on motor scores or adverse events. Depression and somnolence scales significantly favored deutetrabenazine. Conclusion: There is low‐quality evidence that tetrabenazine and deutetrabenazine do not differ in efficacy or safety. It is important to note that these results are likely to remain the only head‐to‐head comparison between these 2 compounds in Huntington's disease.WileyRepositório da Universidade de LisboaRodrigues, Filipe BrogueiraDuarte, Gonçalo SilvaCosta, JoãoFerreira, Joaquim JWild, Edward J.2018-05-08T14:45:39Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/33258engMov Disord Clin Pract. 2017 Jul-Aug; 4(4): 582–5852330-161910.1002/mdc3.12483info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T13:53:53Zoai:repositorio.ulisboa.pt:10451/33258Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T02:57:34.972928Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Tetrabenazine versus deutetrabenazine for Huntington's disease : twins or distant cousins?
title Tetrabenazine versus deutetrabenazine for Huntington's disease : twins or distant cousins?
spellingShingle Tetrabenazine versus deutetrabenazine for Huntington's disease : twins or distant cousins?
Rodrigues, Filipe Brogueira
Deutetrabenazine
Huntington's disease
Indirect comparison
Meta‐analysis
Tetrabenazine
title_short Tetrabenazine versus deutetrabenazine for Huntington's disease : twins or distant cousins?
title_full Tetrabenazine versus deutetrabenazine for Huntington's disease : twins or distant cousins?
title_fullStr Tetrabenazine versus deutetrabenazine for Huntington's disease : twins or distant cousins?
title_full_unstemmed Tetrabenazine versus deutetrabenazine for Huntington's disease : twins or distant cousins?
title_sort Tetrabenazine versus deutetrabenazine for Huntington's disease : twins or distant cousins?
author Rodrigues, Filipe Brogueira
author_facet Rodrigues, Filipe Brogueira
Duarte, Gonçalo Silva
Costa, João
Ferreira, Joaquim J
Wild, Edward J.
author_role author
author2 Duarte, Gonçalo Silva
Costa, João
Ferreira, Joaquim J
Wild, Edward J.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Rodrigues, Filipe Brogueira
Duarte, Gonçalo Silva
Costa, João
Ferreira, Joaquim J
Wild, Edward J.
dc.subject.por.fl_str_mv Deutetrabenazine
Huntington's disease
Indirect comparison
Meta‐analysis
Tetrabenazine
topic Deutetrabenazine
Huntington's disease
Indirect comparison
Meta‐analysis
Tetrabenazine
description © 2017 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2018-05-08T14:45:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/33258
url http://hdl.handle.net/10451/33258
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mov Disord Clin Pract. 2017 Jul-Aug; 4(4): 582–585
2330-1619
10.1002/mdc3.12483
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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