Host-derived biomarkers for risk assessment of invasive fungal diseases

Bibliographic Details
Main Author: Cunha, Cristina Amorim
Publication Date: 2017
Other Authors: Gonçalves, Samuel M., Carvalho, Agostinho Albérico Rodrigues
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/48523
Summary: Host-Derived Biomarkers for Risk Assessment of Invasive Fungal Diseases
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network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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spelling Host-derived biomarkers for risk assessment of invasive fungal diseasesInvasive fungal diseaseSingle nucleotide polymorphism (SNP)Host biomarkersLong pentraxin 3 (PTX3)Antifungal immunityImmunocompromised patientsRisk stratificationPersonalized medicineCiências Médicas::Medicina BásicaScience & TechnologyHost-Derived Biomarkers for Risk Assessment of Invasive Fungal DiseasesInvasive fungal diseases are major complications associated with the treatment of hematologic malignancies. The integration of host-derived biomarkers into clinical processes to predict the risk and progression of fungal disease is a promising approach in immunocompromised patients. Recent insights into human antifungal immunity have highlighted the remarkable influence of host genetics in modulating susceptibility to infection. In this chapter, we describe protocols to examine human genetic variation and to assess its functional consequences using the pattern recognition receptor PTX3 as an example.European Society of Clinical Microbiology and Infectious Diseases (Research Grant 2012 to A.C.) and the Fundação para a Ciência e Tecnologia (FCT) (SFRH/BPD/96176/2013 to C.C. and IF/00735/2014 to A.C.). Further support was provided by FCT, cofunded by Programa Operacional Regional do Norte (ON.2—O Novo Norte), the Quadro de Referência Estratégico Nacional (QREN) through the Fundo Europeu de Desenvolvimento Regional (FEDER), and the Projeto Estratégico PEst-C/SAU/LA0026/2013info:eu-repo/semantics/publishedVersionHumana PressUniversidade do MinhoCunha, Cristina AmorimGonçalves, Samuel M.Carvalho, Agostinho Albérico Rodrigues2017-01-012017-01-01T00:00:00Zbook partinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/1822/48523engCunha, C., Gonçalves, S. M., & Carvalho, A. (2017). Host-Derived Biomarkers for Risk Assessment of Invasive Fungal Diseases. Human Fungal Pathogen Identification: Methods and Protocols, 153-165978-1-4939-6513-71064-374510.1007/978-1-4939-6515-1_7978-1-4939-6515-127837502https://link.springer.com/protocol/10.1007/978-1-4939-6515-1_7info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T04:35:19Zoai:repositorium.sdum.uminho.pt:1822/48523Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:52:29.580273Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Host-derived biomarkers for risk assessment of invasive fungal diseases
title Host-derived biomarkers for risk assessment of invasive fungal diseases
spellingShingle Host-derived biomarkers for risk assessment of invasive fungal diseases
Cunha, Cristina Amorim
Invasive fungal disease
Single nucleotide polymorphism (SNP)
Host biomarkers
Long pentraxin 3 (PTX3)
Antifungal immunity
Immunocompromised patients
Risk stratification
Personalized medicine
Ciências Médicas::Medicina Básica
Science & Technology
title_short Host-derived biomarkers for risk assessment of invasive fungal diseases
title_full Host-derived biomarkers for risk assessment of invasive fungal diseases
title_fullStr Host-derived biomarkers for risk assessment of invasive fungal diseases
title_full_unstemmed Host-derived biomarkers for risk assessment of invasive fungal diseases
title_sort Host-derived biomarkers for risk assessment of invasive fungal diseases
author Cunha, Cristina Amorim
author_facet Cunha, Cristina Amorim
Gonçalves, Samuel M.
Carvalho, Agostinho Albérico Rodrigues
author_role author
author2 Gonçalves, Samuel M.
Carvalho, Agostinho Albérico Rodrigues
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Cunha, Cristina Amorim
Gonçalves, Samuel M.
Carvalho, Agostinho Albérico Rodrigues
dc.subject.por.fl_str_mv Invasive fungal disease
Single nucleotide polymorphism (SNP)
Host biomarkers
Long pentraxin 3 (PTX3)
Antifungal immunity
Immunocompromised patients
Risk stratification
Personalized medicine
Ciências Médicas::Medicina Básica
Science & Technology
topic Invasive fungal disease
Single nucleotide polymorphism (SNP)
Host biomarkers
Long pentraxin 3 (PTX3)
Antifungal immunity
Immunocompromised patients
Risk stratification
Personalized medicine
Ciências Médicas::Medicina Básica
Science & Technology
description Host-Derived Biomarkers for Risk Assessment of Invasive Fungal Diseases
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01
2017-01-01T00:00:00Z
dc.type.driver.fl_str_mv book part
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/48523
url http://hdl.handle.net/1822/48523
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cunha, C., Gonçalves, S. M., & Carvalho, A. (2017). Host-Derived Biomarkers for Risk Assessment of Invasive Fungal Diseases. Human Fungal Pathogen Identification: Methods and Protocols, 153-165
978-1-4939-6513-7
1064-3745
10.1007/978-1-4939-6515-1_7
978-1-4939-6515-1
27837502
https://link.springer.com/protocol/10.1007/978-1-4939-6515-1_7
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Humana Press
publisher.none.fl_str_mv Humana Press
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833594947130884096

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