Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis

Detalhes bibliográficos
Autor(a) principal: Oliveira-Coelho, Ana
Data de Publicação: 2015
Outros Autores: Rodrigues, Fernando, Campos, António, Lacerda, João, Carvalho, Agostinho, Cunha, Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10451/55208
Resumo: Copyright © 2015 Oliveira-Coelho, Rodrigues, Campos Jr., Lacerda, Carvalho and Cunha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosisAntifungal immunityInvasive aspergillosisPersonalized medicineSingle nucleotide polymorphismStem cell transplantationCopyright © 2015 Oliveira-Coelho, Rodrigues, Campos Jr., Lacerda, Carvalho and Cunha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Invasive aspergillosis (IA) is a life-threatening fungal disease commonly diagnosed among individuals with immunological deficits, namely hematological patients undergoing chemotherapy or allogeneic hematopoietic stem cell transplantation. Vaccines are not available, and despite the improved diagnosis and antifungal therapy, the treatment of IA is associated with a poor outcome. Importantly, the risk of infection and its clinical outcome vary significantly even among patients with similar predisposing clinical factors and microbiological exposure. Recent insights into antifungal immunity have further highlighted the complexity of host-fungus interactions and the multiple pathogen-sensing systems activated to control infection. How to decode this information into clinical practice remains however, a challenging issue in medical mycology. Here, we address recent advances in our understanding of the host-fungus interaction and discuss the application of this knowledge in potential strategies with the aim of moving toward personalized diagnostics and treatment (theranostics) in immunocompromised patients. Ultimately, the integration of individual traits into a clinically applicable process to predict the risk and progression of disease, and the efficacy of antifungal prophylaxis and therapy, holds the promise of a pioneering innovation benefiting patients at risk of IA.CC is supported by the Fundação para a Ciência e Tecnologia, Portugal (SFRH/BPD/96176/2013)FrontiersRepositório da Universidade de LisboaOliveira-Coelho, AnaRodrigues, FernandoCampos, AntónioLacerda, JoãoCarvalho, AgostinhoCunha, Cristina2022-11-22T15:18:06Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55208engFront Microbiol. 2015 May 5;6:41110.3389/fmicb.2015.004111664-302Xinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:51:13Zoai:repositorio.ulisboa.pt:10451/55208Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:26:48.129035Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis
title Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis
spellingShingle Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis
Oliveira-Coelho, Ana
Antifungal immunity
Invasive aspergillosis
Personalized medicine
Single nucleotide polymorphism
Stem cell transplantation
title_short Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis
title_full Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis
title_fullStr Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis
title_full_unstemmed Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis
title_sort Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis
author Oliveira-Coelho, Ana
author_facet Oliveira-Coelho, Ana
Rodrigues, Fernando
Campos, António
Lacerda, João
Carvalho, Agostinho
Cunha, Cristina
author_role author
author2 Rodrigues, Fernando
Campos, António
Lacerda, João
Carvalho, Agostinho
Cunha, Cristina
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Oliveira-Coelho, Ana
Rodrigues, Fernando
Campos, António
Lacerda, João
Carvalho, Agostinho
Cunha, Cristina
dc.subject.por.fl_str_mv Antifungal immunity
Invasive aspergillosis
Personalized medicine
Single nucleotide polymorphism
Stem cell transplantation
topic Antifungal immunity
Invasive aspergillosis
Personalized medicine
Single nucleotide polymorphism
Stem cell transplantation
description Copyright © 2015 Oliveira-Coelho, Rodrigues, Campos Jr., Lacerda, Carvalho and Cunha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2022-11-22T15:18:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/55208
url http://hdl.handle.net/10451/55208
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Microbiol. 2015 May 5;6:411
10.3389/fmicb.2015.00411
1664-302X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Frontiers
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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