A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation

Bibliographic Details
Main Author: Dias, André
Publication Date: 2020
Other Authors: Lozovska, Anastasiia, Wymeersch, Filip J., Nóvoa, Ana, Binagui-Casas, Anahi, Sobral, Daniel, Martins, Gabriel G., Wilson, Valerie, Mallo, Moises
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/120727
Summary: LISBOA-01?0145-FEDER-030254 SCML-MC-60-2014 LISBOA-01-0145-FEDER-022170 PD/BD/128426/2017 PD/BD/128437/2017 MR/S008799/1 MR/ K011200/1 DEV-170806
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oai_identifier_str oai:run.unl.pt:10362/120727
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongationNeuroscience(all)Biochemistry, Genetics and Molecular Biology(all)Immunology and Microbiology(all)LISBOA-01?0145-FEDER-030254 SCML-MC-60-2014 LISBOA-01-0145-FEDER-022170 PD/BD/128426/2017 PD/BD/128437/2017 MR/S008799/1 MR/ K011200/1 DEV-170806Formation of the vertebrate postcranial body axis follows two sequential but distinct phases. The first phase generates pre-sacral structures (the so-called primary body) through the activity of the primitive streak on axial progenitors within the epiblast. The embryo then switches to generate the secondary body (post-sacral structures), which depends on axial progenitors in the tail bud. Here we show that the mammalian tail bud is generated through an independent functional developmental module, concurrent but functionally different from that generating the primary body. This module is triggered by convergent Tgfbr1 and Snai1 activities that promote an incomplete epithelial to mesenchymal transition on a subset of epiblast axial progenitors. This EMT is functionally different from that coordinated by the primitive streak, as it does not lead to mesodermal differentiation but brings axial progenitors into a transitory state, keeping their progenitor activity to drive further axial body extension.DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitRUNDias, AndréLozovska, AnastasiiaWymeersch, Filip J.Nóvoa, AnaBinagui-Casas, AnahiSobral, DanielMartins, Gabriel G.Wilson, ValerieMallo, Moises2021-07-08T22:19:30Z2020-062020-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article28application/pdfhttp://hdl.handle.net/10362/120727eng2050-084XPURE: 32427018https://doi.org/10.7554/eLife.56615info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:54:30Zoai:run.unl.pt:10362/120727Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:25:23.861770Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
title A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
spellingShingle A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
Dias, André
Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
title_short A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
title_full A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
title_fullStr A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
title_full_unstemmed A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
title_sort A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
author Dias, André
author_facet Dias, André
Lozovska, Anastasiia
Wymeersch, Filip J.
Nóvoa, Ana
Binagui-Casas, Anahi
Sobral, Daniel
Martins, Gabriel G.
Wilson, Valerie
Mallo, Moises
author_role author
author2 Lozovska, Anastasiia
Wymeersch, Filip J.
Nóvoa, Ana
Binagui-Casas, Anahi
Sobral, Daniel
Martins, Gabriel G.
Wilson, Valerie
Mallo, Moises
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DCV - Departamento de Ciências da Vida
UCIBIO - Applied Molecular Biosciences Unit
RUN
dc.contributor.author.fl_str_mv Dias, André
Lozovska, Anastasiia
Wymeersch, Filip J.
Nóvoa, Ana
Binagui-Casas, Anahi
Sobral, Daniel
Martins, Gabriel G.
Wilson, Valerie
Mallo, Moises
dc.subject.por.fl_str_mv Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
topic Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
description LISBOA-01?0145-FEDER-030254 SCML-MC-60-2014 LISBOA-01-0145-FEDER-022170 PD/BD/128426/2017 PD/BD/128437/2017 MR/S008799/1 MR/ K011200/1 DEV-170806
publishDate 2020
dc.date.none.fl_str_mv 2020-06
2020-06-01T00:00:00Z
2021-07-08T22:19:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/120727
url http://hdl.handle.net/10362/120727
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2050-084X
PURE: 32427018
https://doi.org/10.7554/eLife.56615
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 28
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596686028505088

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