A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Texto Completo: | http://hdl.handle.net/10362/120727 |
Resumo: | LISBOA-01?0145-FEDER-030254 SCML-MC-60-2014 LISBOA-01-0145-FEDER-022170 PD/BD/128426/2017 PD/BD/128437/2017 MR/S008799/1 MR/ K011200/1 DEV-170806 |
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Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
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A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongationNeuroscience(all)Biochemistry, Genetics and Molecular Biology(all)Immunology and Microbiology(all)LISBOA-01?0145-FEDER-030254 SCML-MC-60-2014 LISBOA-01-0145-FEDER-022170 PD/BD/128426/2017 PD/BD/128437/2017 MR/S008799/1 MR/ K011200/1 DEV-170806Formation of the vertebrate postcranial body axis follows two sequential but distinct phases. The first phase generates pre-sacral structures (the so-called primary body) through the activity of the primitive streak on axial progenitors within the epiblast. The embryo then switches to generate the secondary body (post-sacral structures), which depends on axial progenitors in the tail bud. Here we show that the mammalian tail bud is generated through an independent functional developmental module, concurrent but functionally different from that generating the primary body. This module is triggered by convergent Tgfbr1 and Snai1 activities that promote an incomplete epithelial to mesenchymal transition on a subset of epiblast axial progenitors. This EMT is functionally different from that coordinated by the primitive streak, as it does not lead to mesodermal differentiation but brings axial progenitors into a transitory state, keeping their progenitor activity to drive further axial body extension.DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitRUNDias, AndréLozovska, AnastasiiaWymeersch, Filip J.Nóvoa, AnaBinagui-Casas, AnahiSobral, DanielMartins, Gabriel G.Wilson, ValerieMallo, Moises2021-07-08T22:19:30Z2020-062020-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article28application/pdfhttp://hdl.handle.net/10362/120727eng2050-084XPURE: 32427018https://doi.org/10.7554/eLife.56615info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:54:30Zoai:run.unl.pt:10362/120727Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:25:23.861770Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation |
| title |
A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation |
| spellingShingle |
A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation Dias, André Neuroscience(all) Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) |
| title_short |
A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation |
| title_full |
A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation |
| title_fullStr |
A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation |
| title_full_unstemmed |
A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation |
| title_sort |
A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation |
| author |
Dias, André |
| author_facet |
Dias, André Lozovska, Anastasiia Wymeersch, Filip J. Nóvoa, Ana Binagui-Casas, Anahi Sobral, Daniel Martins, Gabriel G. Wilson, Valerie Mallo, Moises |
| author_role |
author |
| author2 |
Lozovska, Anastasiia Wymeersch, Filip J. Nóvoa, Ana Binagui-Casas, Anahi Sobral, Daniel Martins, Gabriel G. Wilson, Valerie Mallo, Moises |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
DCV - Departamento de Ciências da Vida UCIBIO - Applied Molecular Biosciences Unit RUN |
| dc.contributor.author.fl_str_mv |
Dias, André Lozovska, Anastasiia Wymeersch, Filip J. Nóvoa, Ana Binagui-Casas, Anahi Sobral, Daniel Martins, Gabriel G. Wilson, Valerie Mallo, Moises |
| dc.subject.por.fl_str_mv |
Neuroscience(all) Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) |
| topic |
Neuroscience(all) Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) |
| description |
LISBOA-01?0145-FEDER-030254 SCML-MC-60-2014 LISBOA-01-0145-FEDER-022170 PD/BD/128426/2017 PD/BD/128437/2017 MR/S008799/1 MR/ K011200/1 DEV-170806 |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-06 2020-06-01T00:00:00Z 2021-07-08T22:19:30Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/120727 |
| url |
http://hdl.handle.net/10362/120727 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2050-084X PURE: 32427018 https://doi.org/10.7554/eLife.56615 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
28 application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia instacron:RCAAP |
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FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
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RCAAP |
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RCAAP |
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Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
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Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
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Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
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info@rcaap.pt |
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1833596686028505088 |