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Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus

Bibliographic Details
Main Author: Pereira, Florbela
Publication Date: 2020
Other Authors: Almeida, Joana R., Paulino, Marisa, Grilo, Inês R., Macedo, Helena, Cunha, Isabel, Sobral, Rita G., Vasconcelos, Vitor, Gaudêncio, Susana P.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/109141
Summary: UID/Multi/04378/2019 UID/Multi/04423/2019 FP7/2007–2013 DFRH/WIIA/102/2011 SFRH/BI/52130/ 2013 IF/00700/2014 SFRH/BPD/110020/2015 PTDC/BIA-MIC/31645/2017 PTDC/BTA-GES/ 32359/2017 PTDC/BTA-BTA/31422/2017 POCI-01-0145-FEDER-031422
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oai_identifier_str oai:run.unl.pt:10362/109141
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatusActinomycetesAntibiofilmAntifoulingBiofoulingBioprospectionDrug discoveryHybrid isoprenoidsMarine natural productsMeroterpenoidsNapyradiomycinsDrug DiscoverySDG 14 - Life Below WaterUID/Multi/04378/2019 UID/Multi/04423/2019 FP7/2007–2013 DFRH/WIIA/102/2011 SFRH/BI/52130/ 2013 IF/00700/2014 SFRH/BPD/110020/2015 PTDC/BIA-MIC/31645/2017 PTDC/BTA-GES/ 32359/2017 PTDC/BTA-BTA/31422/2017 POCI-01-0145-FEDER-031422The undesired attachment of micro and macroorganisms on water-immersed surfaces, known as marine biofouling, results in severe prevention and maintenance costs (billions €/year) for aquaculture, shipping and other industries that rely on coastal and off-shore infrastructures. To date, there are no sustainable, cost-effective and environmentally safe solutions to address this challenging phenomenon. Therefore, we investigated the antifouling activity of napyradiomycin derivatives that were isolated from actinomycetes from ocean sediments collected off the Madeira Archipelago. Our results revealed that napyradiomycins inhibited ≥80% of the marine biofilm-forming bacteria assayed, as well as the settlement of Mytilus galloprovincialis larvae (EC50 < 5 µg/ml and LC50/EC50 >15), without viability impairment. In silico prediction of toxicity end points are of the same order of magnitude of standard approved drugs and biocides. Altogether, napyradiomycins disclosed bioactivity against marine micro and macrofouling organisms, and non-toxic effects towards the studied species, displaying potential to be used in the development of antifouling products.LAQV@REQUIMTEDQ - Departamento de QuímicaUCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaRUNPereira, FlorbelaAlmeida, Joana R.Paulino, MarisaGrilo, Inês R.Macedo, HelenaCunha, IsabelSobral, Rita G.Vasconcelos, VitorGaudêncio, Susana P.2020-12-22T05:15:19Z2020-01-182020-01-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/109141eng1660-3397PURE: 17107846https://doi.org/10.3390/md18010063info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:49:31Zoai:run.unl.pt:10362/109141Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:20:52.418063Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
title Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
spellingShingle Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
Pereira, Florbela
Actinomycetes
Antibiofilm
Antifouling
Biofouling
Bioprospection
Drug discovery
Hybrid isoprenoids
Marine natural products
Meroterpenoids
Napyradiomycins
Drug Discovery
SDG 14 - Life Below Water
title_short Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
title_full Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
title_fullStr Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
title_full_unstemmed Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
title_sort Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
author Pereira, Florbela
author_facet Pereira, Florbela
Almeida, Joana R.
Paulino, Marisa
Grilo, Inês R.
Macedo, Helena
Cunha, Isabel
Sobral, Rita G.
Vasconcelos, Vitor
Gaudêncio, Susana P.
author_role author
author2 Almeida, Joana R.
Paulino, Marisa
Grilo, Inês R.
Macedo, Helena
Cunha, Isabel
Sobral, Rita G.
Vasconcelos, Vitor
Gaudêncio, Susana P.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
UCIBIO - Applied Molecular Biosciences Unit
DCV - Departamento de Ciências da Vida
RUN
dc.contributor.author.fl_str_mv Pereira, Florbela
Almeida, Joana R.
Paulino, Marisa
Grilo, Inês R.
Macedo, Helena
Cunha, Isabel
Sobral, Rita G.
Vasconcelos, Vitor
Gaudêncio, Susana P.
dc.subject.por.fl_str_mv Actinomycetes
Antibiofilm
Antifouling
Biofouling
Bioprospection
Drug discovery
Hybrid isoprenoids
Marine natural products
Meroterpenoids
Napyradiomycins
Drug Discovery
SDG 14 - Life Below Water
topic Actinomycetes
Antibiofilm
Antifouling
Biofouling
Bioprospection
Drug discovery
Hybrid isoprenoids
Marine natural products
Meroterpenoids
Napyradiomycins
Drug Discovery
SDG 14 - Life Below Water
description UID/Multi/04378/2019 UID/Multi/04423/2019 FP7/2007–2013 DFRH/WIIA/102/2011 SFRH/BI/52130/ 2013 IF/00700/2014 SFRH/BPD/110020/2015 PTDC/BIA-MIC/31645/2017 PTDC/BTA-GES/ 32359/2017 PTDC/BTA-BTA/31422/2017 POCI-01-0145-FEDER-031422
publishDate 2020
dc.date.none.fl_str_mv 2020-12-22T05:15:19Z
2020-01-18
2020-01-18T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/109141
url http://hdl.handle.net/10362/109141
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1660-3397
PURE: 17107846
https://doi.org/10.3390/md18010063
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596628008697856

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