Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger

Bibliographic Details
Main Author: Abade dos Santos, F.A.
Publication Date: 2022
Other Authors: Pinto, Andreia, Burgoyne, Thomas, Dalton, Kevin P., Carvalho, Carina L., Ramilo, David, Carneiro, Carla, Carvalho, Tânia, Peleteiro, Conceição, Parra, Francisco, M. Duarte, M. D. Duarte, M. M. Duarte
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.5/24465
Summary: Áreas de pesquisa: Infectious Diseases ; Veterinary Sciences
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spelling Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badgerEurasian badgerGI.2Meles melesrecombinant GI.4P-GI.2RHDV2/bspillover eventÁreas de pesquisa: Infectious Diseases ; Veterinary SciencesRabbit haemorrhagic disease (RHD) is a major threat to domestic and wild European rabbits. Presently, in Europe, the disease is caused mainly by Rabbit haemorrhagic disease virus 2 (RHDV2/b or Lagovirus europaeus GI.2), the origin of which is still unclear, as no RHDV2 reservoir hosts were identified. After the RHDV2 emergence in 2010, viral RNA was detected in a few rodent species. Furthermore, RHDV2 was found to cause disease in some hare species resembling the disease in rabbits, evidencing the ability of the virus to cross the species barrier. In this study, through molecular, histopathologic, antigenic and morphological evidences, we demonstrate the presence and replication of RHDV2 in Eurasian badgers (Meles meles) found dead in the district of Santarém, Portugal, between March 2017 and January 2020. In these animals, we further classify the RHDV2 as a Lagovirus europaeus recombinant GI.4P-GI.2. Our results indicate that Meles meles is susceptible to RHDV2, developing systemic infection, and excreting the virus in the faeces. Given the high viral loads seen in several organs and matrices, we believe that transmission to the wild rabbit is likely. Furthermore, transmission electron microscopy data show the presence of calicivirus compatible virions in the nucleus of hepatocytes, which constitutes a paradigm shift for caliciviruses’ replication cycleWileyRepositório da Universidade de LisboaAbade dos Santos, F.A.Pinto, AndreiaBurgoyne, ThomasDalton, Kevin P.Carvalho, Carina L.Ramilo, DavidCarneiro, CarlaCarvalho, TâniaPeleteiro, ConceiçãoParra, FranciscoM. Duarte, M. D. Duarte, M. M. Duarte2022-06-01T23:02:29Z2022-052022-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24465engAbade dos Santos FA, Pinto A, Burgoyne T, Dalton KP, Carvalho CL, Ramilo DW, Carneiro C, Carvalho T, Peleteiro, MC, Parra F. 2022. Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger. Transboundary and Emerging Diseases, 69(3): pp.1030-1045. DOI10.1111/tbed.140591865-167410.1111/tbed.140591865-1682info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T15:24:45Zoai:repositorio.ulisboa.pt:10400.5/24465Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:42:29.606294Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger
title Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger
spellingShingle Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger
Abade dos Santos, F.A.
Eurasian badger
GI.2
Meles meles
recombinant GI.4P-GI.2
RHDV2/b
spillover event
title_short Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger
title_full Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger
title_fullStr Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger
title_full_unstemmed Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger
title_sort Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger
author Abade dos Santos, F.A.
author_facet Abade dos Santos, F.A.
Pinto, Andreia
Burgoyne, Thomas
Dalton, Kevin P.
Carvalho, Carina L.
Ramilo, David
Carneiro, Carla
Carvalho, Tânia
Peleteiro, Conceição
Parra, Francisco
M. Duarte, M. D. Duarte, M. M. Duarte
author_role author
author2 Pinto, Andreia
Burgoyne, Thomas
Dalton, Kevin P.
Carvalho, Carina L.
Ramilo, David
Carneiro, Carla
Carvalho, Tânia
Peleteiro, Conceição
Parra, Francisco
M. Duarte, M. D. Duarte, M. M. Duarte
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Abade dos Santos, F.A.
Pinto, Andreia
Burgoyne, Thomas
Dalton, Kevin P.
Carvalho, Carina L.
Ramilo, David
Carneiro, Carla
Carvalho, Tânia
Peleteiro, Conceição
Parra, Francisco
M. Duarte, M. D. Duarte, M. M. Duarte
dc.subject.por.fl_str_mv Eurasian badger
GI.2
Meles meles
recombinant GI.4P-GI.2
RHDV2/b
spillover event
topic Eurasian badger
GI.2
Meles meles
recombinant GI.4P-GI.2
RHDV2/b
spillover event
description Áreas de pesquisa: Infectious Diseases ; Veterinary Sciences
publishDate 2022
dc.date.none.fl_str_mv 2022-06-01T23:02:29Z
2022-05
2022-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/24465
url http://hdl.handle.net/10400.5/24465
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Abade dos Santos FA, Pinto A, Burgoyne T, Dalton KP, Carvalho CL, Ramilo DW, Carneiro C, Carvalho T, Peleteiro, MC, Parra F. 2022. Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger. Transboundary and Emerging Diseases, 69(3): pp.1030-1045. DOI10.1111/tbed.14059
1865-1674
10.1111/tbed.14059
1865-1682
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833601802779492352

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