Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger
| Main Author: | |
|---|---|
| Publication Date: | 2022 |
| Other Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10400.5/24465 |
Summary: | Áreas de pesquisa: Infectious Diseases ; Veterinary Sciences |
| id |
RCAP_e16eb4aef1a8ebd23a9f3c1eaf80a541 |
|---|---|
| oai_identifier_str |
oai:repositorio.ulisboa.pt:10400.5/24465 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| repository_id_str |
https://opendoar.ac.uk/repository/7160 |
| spelling |
Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badgerEurasian badgerGI.2Meles melesrecombinant GI.4P-GI.2RHDV2/bspillover eventÁreas de pesquisa: Infectious Diseases ; Veterinary SciencesRabbit haemorrhagic disease (RHD) is a major threat to domestic and wild European rabbits. Presently, in Europe, the disease is caused mainly by Rabbit haemorrhagic disease virus 2 (RHDV2/b or Lagovirus europaeus GI.2), the origin of which is still unclear, as no RHDV2 reservoir hosts were identified. After the RHDV2 emergence in 2010, viral RNA was detected in a few rodent species. Furthermore, RHDV2 was found to cause disease in some hare species resembling the disease in rabbits, evidencing the ability of the virus to cross the species barrier. In this study, through molecular, histopathologic, antigenic and morphological evidences, we demonstrate the presence and replication of RHDV2 in Eurasian badgers (Meles meles) found dead in the district of Santarém, Portugal, between March 2017 and January 2020. In these animals, we further classify the RHDV2 as a Lagovirus europaeus recombinant GI.4P-GI.2. Our results indicate that Meles meles is susceptible to RHDV2, developing systemic infection, and excreting the virus in the faeces. Given the high viral loads seen in several organs and matrices, we believe that transmission to the wild rabbit is likely. Furthermore, transmission electron microscopy data show the presence of calicivirus compatible virions in the nucleus of hepatocytes, which constitutes a paradigm shift for caliciviruses’ replication cycleWileyRepositório da Universidade de LisboaAbade dos Santos, F.A.Pinto, AndreiaBurgoyne, ThomasDalton, Kevin P.Carvalho, Carina L.Ramilo, DavidCarneiro, CarlaCarvalho, TâniaPeleteiro, ConceiçãoParra, FranciscoM. Duarte, M. D. Duarte, M. M. Duarte2022-06-01T23:02:29Z2022-052022-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24465engAbade dos Santos FA, Pinto A, Burgoyne T, Dalton KP, Carvalho CL, Ramilo DW, Carneiro C, Carvalho T, Peleteiro, MC, Parra F. 2022. Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger. Transboundary and Emerging Diseases, 69(3): pp.1030-1045. DOI10.1111/tbed.140591865-167410.1111/tbed.140591865-1682info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T15:24:45Zoai:repositorio.ulisboa.pt:10400.5/24465Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:42:29.606294Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger |
| title |
Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger |
| spellingShingle |
Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger Abade dos Santos, F.A. Eurasian badger GI.2 Meles meles recombinant GI.4P-GI.2 RHDV2/b spillover event |
| title_short |
Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger |
| title_full |
Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger |
| title_fullStr |
Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger |
| title_full_unstemmed |
Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger |
| title_sort |
Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger |
| author |
Abade dos Santos, F.A. |
| author_facet |
Abade dos Santos, F.A. Pinto, Andreia Burgoyne, Thomas Dalton, Kevin P. Carvalho, Carina L. Ramilo, David Carneiro, Carla Carvalho, Tânia Peleteiro, Conceição Parra, Francisco M. Duarte, M. D. Duarte, M. M. Duarte |
| author_role |
author |
| author2 |
Pinto, Andreia Burgoyne, Thomas Dalton, Kevin P. Carvalho, Carina L. Ramilo, David Carneiro, Carla Carvalho, Tânia Peleteiro, Conceição Parra, Francisco M. Duarte, M. D. Duarte, M. M. Duarte |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Abade dos Santos, F.A. Pinto, Andreia Burgoyne, Thomas Dalton, Kevin P. Carvalho, Carina L. Ramilo, David Carneiro, Carla Carvalho, Tânia Peleteiro, Conceição Parra, Francisco M. Duarte, M. D. Duarte, M. M. Duarte |
| dc.subject.por.fl_str_mv |
Eurasian badger GI.2 Meles meles recombinant GI.4P-GI.2 RHDV2/b spillover event |
| topic |
Eurasian badger GI.2 Meles meles recombinant GI.4P-GI.2 RHDV2/b spillover event |
| description |
Áreas de pesquisa: Infectious Diseases ; Veterinary Sciences |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-06-01T23:02:29Z 2022-05 2022-05-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.5/24465 |
| url |
http://hdl.handle.net/10400.5/24465 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Abade dos Santos FA, Pinto A, Burgoyne T, Dalton KP, Carvalho CL, Ramilo DW, Carneiro C, Carvalho T, Peleteiro, MC, Parra F. 2022. Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger. Transboundary and Emerging Diseases, 69(3): pp.1030-1045. DOI10.1111/tbed.14059 1865-1674 10.1111/tbed.14059 1865-1682 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley |
| publisher.none.fl_str_mv |
Wiley |
| dc.source.none.fl_str_mv |
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia instacron:RCAAP |
| instname_str |
FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| collection |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| repository.name.fl_str_mv |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
| repository.mail.fl_str_mv |
info@rcaap.pt |
| _version_ |
1833601802779492352 |