Cell non-autonomous proteostasis regulation in aging and disease

Bibliographic Details
Main Author: Ferreira, Joao Vasco
Publication Date: 2022
Other Authors: da Rosa Soares, Ana, Pereira, Paulo
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/143972
Summary: Funding: This study was supported by the “Programa Operacional Regional de Lisboa-FEDER/ Project 02/SAICT/2020/072552,” and iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020, and by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), two programs financially supported by Fundação para a Ciência e Tecnologia / Ministério da Ciência, Tecnologia e Ensino Superior.
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spelling Cell non-autonomous proteostasis regulation in aging and diseasemisfoldingmolecular chaperonesproteostasisproteotoxicitytranscellularFunding: This study was supported by the “Programa Operacional Regional de Lisboa-FEDER/ Project 02/SAICT/2020/072552,” and iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020, and by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), two programs financially supported by Fundação para a Ciência e Tecnologia / Ministério da Ciência, Tecnologia e Ensino Superior.Aging is a risk factor for a number of diseases, being the more notorious ones perhaps neurodegenerative diseases such as Alzheimer's and Parkinson's. These and other age-related pathologies are often associated with accumulation of proteotoxic material inside cells, as well as with the accumulation of protein deposits extracellularly. It is widely accepted that this accumulation of toxic proteins trails a progressive decline in the mechanisms that regulate protein homeostasis, or proteostasis, during aging. However, despite significant efforts, the progress in terms of novel or improved therapies targeting accumulation of proteotoxic material has been rather limited. For example, clinical trials for new drugs aimed at treating Alzheimer's disease, by preventing accumulation of toxic proteins, have notoriously failed. On the other hand, it is becoming increasingly apparent that regulation of proteostasis is not a cell autonomous process. In fact, cells rely on complex transcellular networks to maintain tissue and organ homeostasis involving endocrine and paracrine signaling pathways. In this review we will discuss the impact of cell non-autonomous proteostasis mechanisms and their impact in aging and disease. We will focus on how transcellular proteostasis networks can shed new light into stablished paradigms about the aging of organisms.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNFerreira, Joao Vascoda Rosa Soares, AnaPereira, Paulo2022-09-22T22:37:30Z2022-06-092022-06-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/143972eng1662-4548PURE: 46538098https://doi.org/10.3389/fnins.2022.878296info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:05:18Zoai:run.unl.pt:10362/143972Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:35:52.092993Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Cell non-autonomous proteostasis regulation in aging and disease
title Cell non-autonomous proteostasis regulation in aging and disease
spellingShingle Cell non-autonomous proteostasis regulation in aging and disease
Ferreira, Joao Vasco
misfolding
molecular chaperones
proteostasis
proteotoxicity
transcellular
title_short Cell non-autonomous proteostasis regulation in aging and disease
title_full Cell non-autonomous proteostasis regulation in aging and disease
title_fullStr Cell non-autonomous proteostasis regulation in aging and disease
title_full_unstemmed Cell non-autonomous proteostasis regulation in aging and disease
title_sort Cell non-autonomous proteostasis regulation in aging and disease
author Ferreira, Joao Vasco
author_facet Ferreira, Joao Vasco
da Rosa Soares, Ana
Pereira, Paulo
author_role author
author2 da Rosa Soares, Ana
Pereira, Paulo
author2_role author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Ferreira, Joao Vasco
da Rosa Soares, Ana
Pereira, Paulo
dc.subject.por.fl_str_mv misfolding
molecular chaperones
proteostasis
proteotoxicity
transcellular
topic misfolding
molecular chaperones
proteostasis
proteotoxicity
transcellular
description Funding: This study was supported by the “Programa Operacional Regional de Lisboa-FEDER/ Project 02/SAICT/2020/072552,” and iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020, and by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), two programs financially supported by Fundação para a Ciência e Tecnologia / Ministério da Ciência, Tecnologia e Ensino Superior.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-22T22:37:30Z
2022-06-09
2022-06-09T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/143972
url http://hdl.handle.net/10362/143972
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1662-4548
PURE: 46538098
https://doi.org/10.3389/fnins.2022.878296
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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