The disruption of proteostasis in neurodegenerative diseases

Bibliographic Details
Main Author: Jalles, Ana
Publication Date: 2015
Other Authors: Maciel, P.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/51441
Summary: Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.
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spelling The disruption of proteostasis in neurodegenerative diseasesproteostasmolecular chaperonesunfolded protein responseproteasomeautophagytherapeutic strategiesproteostasisScience & TechnologyCells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersionAIMS PressUniversidade do MinhoJalles, AnaMaciel, P.2015-062015-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/51441eng2372-03012372-030110.3934/molsci.2015.3.259http://www.aimspress.cominfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T04:52:44Zoai:repositorium.sdum.uminho.pt:1822/51441Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T15:01:16.154359Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The disruption of proteostasis in neurodegenerative diseases
title The disruption of proteostasis in neurodegenerative diseases
spellingShingle The disruption of proteostasis in neurodegenerative diseases
Jalles, Ana
proteostas
molecular chaperones
unfolded protein response
proteasome
autophagy
therapeutic strategies
proteostasis
Science & Technology
title_short The disruption of proteostasis in neurodegenerative diseases
title_full The disruption of proteostasis in neurodegenerative diseases
title_fullStr The disruption of proteostasis in neurodegenerative diseases
title_full_unstemmed The disruption of proteostasis in neurodegenerative diseases
title_sort The disruption of proteostasis in neurodegenerative diseases
author Jalles, Ana
author_facet Jalles, Ana
Maciel, P.
author_role author
author2 Maciel, P.
author2_role author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Jalles, Ana
Maciel, P.
dc.subject.por.fl_str_mv proteostas
molecular chaperones
unfolded protein response
proteasome
autophagy
therapeutic strategies
proteostasis
Science & Technology
topic proteostas
molecular chaperones
unfolded protein response
proteasome
autophagy
therapeutic strategies
proteostasis
Science & Technology
description Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.
publishDate 2015
dc.date.none.fl_str_mv 2015-06
2015-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/51441
url http://hdl.handle.net/1822/51441
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2372-0301
2372-0301
10.3934/molsci.2015.3.259
http://www.aimspress.com
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv AIMS Press
publisher.none.fl_str_mv AIMS Press
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833595047292960768

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