Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression

Detalhes bibliográficos
Autor(a) principal: Barroso, Madalena
Data de Publicação: 2014
Outros Autores: Florindo, Cristina, Kalwa, Hermann, Silva, Zélia, Turanov, Anton A., Carlson, Bradley A., De Almeida, Isabel Tavares, Blom, Henk J., Gladyshev, Vadim N., Hatfield, Dolph L., Michel, Thomas, Castro, Rita, Loscalzo, Joseph, Handy, Diane E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: https://doi.org/10.1074/jbc.M114.549782
Resumo: This work was supported, in whole or in part, by National Institutes of Health Grants HL067195, HL070819, HL048743, HL107192, and HL108630 (to J. L.); HL46457 and HL48743 (to T. M.); and GM061603 (to V. N. G.). This work was also supported by an American Heart Association postdoctoral fellowship grant (to H. K.) and by Portuguese Fundacao para a Ciencia e a Tecnologia Grants PTDC/SAU-ORG/112683/2009 (to R. C.) and SFRH/BD/73021/2010 (M. B.).
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spelling Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expressionBiochemistryMolecular BiologyCell BiologyThis work was supported, in whole or in part, by National Institutes of Health Grants HL067195, HL070819, HL048743, HL107192, and HL108630 (to J. L.); HL46457 and HL48743 (to T. M.); and GM061603 (to V. N. G.). This work was also supported by an American Heart Association postdoctoral fellowship grant (to H. K.) and by Portuguese Fundacao para a Ciencia e a Tecnologia Grants PTDC/SAU-ORG/112683/2009 (to R. C.) and SFRH/BD/73021/2010 (M. B.).Background: Methylation of tRNASec facilitates the incorporation of selenocysteine at a UGA codon during translation. Results: Accumulation of the homocysteine precursor S-adenosylhomocysteine decreases tRNASec methylation, reducing glutathione peroxidase 1 expression and increasing oxidative stress-induced inflammatory activation of endothelial cells. Conclusion: Methylation modulates the expression of selenoproteins to regulate redox-dependent inflammatory pathways. Significance: Hypomethylation stress promotes a proatherogenic endothelial cell phenotype.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNBarroso, MadalenaFlorindo, CristinaKalwa, HermannSilva, ZéliaTuranov, Anton A.Carlson, Bradley A.De Almeida, Isabel TavaresBlom, Henk J.Gladyshev, Vadim N.Hatfield, Dolph L.Michel, ThomasCastro, RitaLoscalzo, JosephHandy, Diane E.2018-06-26T22:08:51Z2014-05-302014-05-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13application/pdfhttps://doi.org/10.1074/jbc.M114.549782eng0021-9258PURE: 4445823http://www.scopus.com/inward/record.url?scp=84901724596&partnerID=8YFLogxKhttps://doi.org/10.1074/jbc.M114.549782info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:33:39Zoai:run.unl.pt:10362/40318Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:04:40.577380Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression
title Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression
spellingShingle Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression
Barroso, Madalena
Biochemistry
Molecular Biology
Cell Biology
title_short Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression
title_full Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression
title_fullStr Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression
title_full_unstemmed Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression
title_sort Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression
author Barroso, Madalena
author_facet Barroso, Madalena
Florindo, Cristina
Kalwa, Hermann
Silva, Zélia
Turanov, Anton A.
Carlson, Bradley A.
De Almeida, Isabel Tavares
Blom, Henk J.
Gladyshev, Vadim N.
Hatfield, Dolph L.
Michel, Thomas
Castro, Rita
Loscalzo, Joseph
Handy, Diane E.
author_role author
author2 Florindo, Cristina
Kalwa, Hermann
Silva, Zélia
Turanov, Anton A.
Carlson, Bradley A.
De Almeida, Isabel Tavares
Blom, Henk J.
Gladyshev, Vadim N.
Hatfield, Dolph L.
Michel, Thomas
Castro, Rita
Loscalzo, Joseph
Handy, Diane E.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Barroso, Madalena
Florindo, Cristina
Kalwa, Hermann
Silva, Zélia
Turanov, Anton A.
Carlson, Bradley A.
De Almeida, Isabel Tavares
Blom, Henk J.
Gladyshev, Vadim N.
Hatfield, Dolph L.
Michel, Thomas
Castro, Rita
Loscalzo, Joseph
Handy, Diane E.
dc.subject.por.fl_str_mv Biochemistry
Molecular Biology
Cell Biology
topic Biochemistry
Molecular Biology
Cell Biology
description This work was supported, in whole or in part, by National Institutes of Health Grants HL067195, HL070819, HL048743, HL107192, and HL108630 (to J. L.); HL46457 and HL48743 (to T. M.); and GM061603 (to V. N. G.). This work was also supported by an American Heart Association postdoctoral fellowship grant (to H. K.) and by Portuguese Fundacao para a Ciencia e a Tecnologia Grants PTDC/SAU-ORG/112683/2009 (to R. C.) and SFRH/BD/73021/2010 (M. B.).
publishDate 2014
dc.date.none.fl_str_mv 2014-05-30
2014-05-30T00:00:00Z
2018-06-26T22:08:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1074/jbc.M114.549782
url https://doi.org/10.1074/jbc.M114.549782
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0021-9258
PURE: 4445823
http://www.scopus.com/inward/record.url?scp=84901724596&partnerID=8YFLogxK
https://doi.org/10.1074/jbc.M114.549782
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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