Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes

Bibliographic Details
Main Author: Terao, Mineko
Publication Date: 2020
Other Authors: Garattini, Enrico, Romão, Maria João, Leimkühler, Silke
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/107682
Summary: This work was supported by Deutsche Forschungsgemeinschaft Grant Le1171/8-3 (to S. L.). FCT-MCTES, research unit UCIBIO (UID/Multi/04378/2019). project PTDC/BBB-BEP/1185/2014 (to M. J. R.). Fondazione Italo Monzino and the Associazione per la Ricerca sul Cancro (AIRC) (to E. G.).
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spelling Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotesBiochemistryMolecular BiologyCell BiologyThis work was supported by Deutsche Forschungsgemeinschaft Grant Le1171/8-3 (to S. L.). FCT-MCTES, research unit UCIBIO (UID/Multi/04378/2019). project PTDC/BBB-BEP/1185/2014 (to M. J. R.). Fondazione Italo Monzino and the Associazione per la Ricerca sul Cancro (AIRC) (to E. G.).Aldehyde oxidases (AOXs) are a small group of enzymes belonging to the larger family of molybdo-flavoenzymes, along with the well-characterized xanthine oxidoreductase. The two major types of reactions that are catalyzed by AOXs are the hydroxylation of heterocycles and the oxidation of aldehydes to their corresponding carboxylic acids. Different animal species have different complements of AOX genes. The two extremes are represented in humans and rodents; whereas the human genome contains a single active gene (AOX1), those of rodents, such as mice, are endowed with four genes (Aox1-4), clustering on the same chromosome, each encoding a functionally distinct AOX enzyme. It still remains enigmatic why some species have numerous AOX enzymes, whereas others harbor only one functional enzyme. At present, little is known about the physiological relevance of AOX enzymes in humans and their additional forms in other mammals. These enzymes are expressed in the liver and play an important role in the metabolisms of drugs and other xenobiotics. In this review, we discuss the expression, tissue-specific roles, and substrate specificities of the different mammalian AOX enzymes and highlight insights into their physiological roles.DQ - Departamento de QuímicaUCIBIO - Applied Molecular Biosciences UnitRUNTerao, MinekoGarattini, EnricoRomão, Maria JoãoLeimkühler, Silke2022-03-31T00:31:40Z2020-04-172020-04-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other13application/pdfhttp://hdl.handle.net/10362/107682eng0021-9258PURE: 20258452https://doi.org/10.1074/jbc.REV119.007741info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:48:56Zoai:run.unl.pt:10362/107682Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:20:00.308787Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes
title Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes
spellingShingle Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes
Terao, Mineko
Biochemistry
Molecular Biology
Cell Biology
title_short Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes
title_full Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes
title_fullStr Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes
title_full_unstemmed Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes
title_sort Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes
author Terao, Mineko
author_facet Terao, Mineko
Garattini, Enrico
Romão, Maria João
Leimkühler, Silke
author_role author
author2 Garattini, Enrico
Romão, Maria João
Leimkühler, Silke
author2_role author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
UCIBIO - Applied Molecular Biosciences Unit
RUN
dc.contributor.author.fl_str_mv Terao, Mineko
Garattini, Enrico
Romão, Maria João
Leimkühler, Silke
dc.subject.por.fl_str_mv Biochemistry
Molecular Biology
Cell Biology
topic Biochemistry
Molecular Biology
Cell Biology
description This work was supported by Deutsche Forschungsgemeinschaft Grant Le1171/8-3 (to S. L.). FCT-MCTES, research unit UCIBIO (UID/Multi/04378/2019). project PTDC/BBB-BEP/1185/2014 (to M. J. R.). Fondazione Italo Monzino and the Associazione per la Ricerca sul Cancro (AIRC) (to E. G.).
publishDate 2020
dc.date.none.fl_str_mv 2020-04-17
2020-04-17T00:00:00Z
2022-03-31T00:31:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/107682
url http://hdl.handle.net/10362/107682
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0021-9258
PURE: 20258452
https://doi.org/10.1074/jbc.REV119.007741
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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