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Urinary biomarkers in bladder cancer : where do we stand and potential role of extracellular vesicles

Bibliographic Details
Main Author: Oliveira, Manuel Castanheira de
Publication Date: 2020
Other Authors: Caires, Hugo R., Oliveira, Maria J., Fraga, Avelino, Vasconcelos, M. Helena, Ribeiro, Ricardo
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/46427
Summary: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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spelling Urinary biomarkers in bladder cancer : where do we stand and potential role of extracellular vesiclesExtracellular vesiclesMicrovesiclesBladder cancerUrothelial cancerBiomarkersLiquid biopsy© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).Extracellular vesicles (EVs) are small membrane vesicles released by all cells and involved in intercellular communication. Importantly, EVs cargo includes nucleic acids, lipids, and proteins constantly transferred between different cell types, contributing to autocrine and paracrine signaling. In recent years, they have been shown to play vital roles, not only in normal biological functions, but also in pathological conditions, such as cancer. In the multistep process of cancer progression, EVs act at different levels, from stimulation of neoplastic transformation, proliferation, promotion of angiogenesis, migration, invasion, and formation of metastatic niches in distant organs, to immune escape and therapy resistance. Moreover, as products of their parental cells, reflecting their genetic signatures and phenotypes, EVs hold great promise as diagnostic and prognostic biomarkers. Importantly, their potential to overcome the current limitations or the present diagnostic procedures has created interest in bladder cancer (BCa). Indeed, cystoscopy is an invasive and costly technique, whereas cytology has poor sensitivity for early staged and low-grade disease. Several urine-based biomarkers for BCa were found to overcome these limitations. Here, we review their potential advantages and downfalls. In addition, recent literature on the potential of EVs to improve BCa management was reviewed and discussed.The work of our laboratory is funded by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operational Programme for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT—Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Ensino Superior in the framework of the project "Institute for Research and Innovation in Health Sciences" (POCI-01-0145-FEDER-007274).MDPIRepositório da Universidade de LisboaOliveira, Manuel Castanheira deCaires, Hugo R.Oliveira, Maria J.Fraga, AvelinoVasconcelos, M. HelenaRibeiro, Ricardo2021-02-18T16:34:43Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46427engCancers. 2020; 12(6):140010.3390/cancers120614002072-6694info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:28:34Zoai:repositorio.ulisboa.pt:10451/46427Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:12:57.527552Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Urinary biomarkers in bladder cancer : where do we stand and potential role of extracellular vesicles
title Urinary biomarkers in bladder cancer : where do we stand and potential role of extracellular vesicles
spellingShingle Urinary biomarkers in bladder cancer : where do we stand and potential role of extracellular vesicles
Oliveira, Manuel Castanheira de
Extracellular vesicles
Microvesicles
Bladder cancer
Urothelial cancer
Biomarkers
Liquid biopsy
title_short Urinary biomarkers in bladder cancer : where do we stand and potential role of extracellular vesicles
title_full Urinary biomarkers in bladder cancer : where do we stand and potential role of extracellular vesicles
title_fullStr Urinary biomarkers in bladder cancer : where do we stand and potential role of extracellular vesicles
title_full_unstemmed Urinary biomarkers in bladder cancer : where do we stand and potential role of extracellular vesicles
title_sort Urinary biomarkers in bladder cancer : where do we stand and potential role of extracellular vesicles
author Oliveira, Manuel Castanheira de
author_facet Oliveira, Manuel Castanheira de
Caires, Hugo R.
Oliveira, Maria J.
Fraga, Avelino
Vasconcelos, M. Helena
Ribeiro, Ricardo
author_role author
author2 Caires, Hugo R.
Oliveira, Maria J.
Fraga, Avelino
Vasconcelos, M. Helena
Ribeiro, Ricardo
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Oliveira, Manuel Castanheira de
Caires, Hugo R.
Oliveira, Maria J.
Fraga, Avelino
Vasconcelos, M. Helena
Ribeiro, Ricardo
dc.subject.por.fl_str_mv Extracellular vesicles
Microvesicles
Bladder cancer
Urothelial cancer
Biomarkers
Liquid biopsy
topic Extracellular vesicles
Microvesicles
Bladder cancer
Urothelial cancer
Biomarkers
Liquid biopsy
description © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-02-18T16:34:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/46427
url http://hdl.handle.net/10451/46427
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cancers. 2020; 12(6):1400
10.3390/cancers12061400
2072-6694
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
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instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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