Optimizing the discovery of predictors of vaso-occlusion in sickle-cell disease by proteomics

Bibliographic Details
Main Author: Lavinha, João
Publication Date: 2012
Other Authors: Charro, Nuno, Vaz, Fátima, Morais, Anabela, Penque, Deborah
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.18/1312
Summary: Painful crises are the major sickle-cell disease (SCD) clinical manifestation probably due to significant increase in dense red blood cells (RBC) and reduction of their ability to pass through capillaries. Using proteomic strategies (see figure below), we aimed to discover novel SCD prognosis biomarkers as early predictors of the transition from steady-state to vaso-occlusive crises thus, allowing a prompt and specific therapeutic intervention.
id RCAP_c1dc4efa4a586aeb3e12c74396c3e8c5
oai_identifier_str oai:repositorio.insa.pt:10400.18/1312
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Optimizing the discovery of predictors of vaso-occlusion in sickle-cell disease by proteomicsSickle Cell DiseasePlasma ProteomeGenómica Funcional e EstruturalPainful crises are the major sickle-cell disease (SCD) clinical manifestation probably due to significant increase in dense red blood cells (RBC) and reduction of their ability to pass through capillaries. Using proteomic strategies (see figure below), we aimed to discover novel SCD prognosis biomarkers as early predictors of the transition from steady-state to vaso-occlusive crises thus, allowing a prompt and specific therapeutic intervention.Instituto Nacional de Saúde Doutor Ricardo Jorge, IPRepositório Científico do Instituto Nacional de SaúdeLavinha, JoãoCharro, NunoVaz, FátimaMorais, AnabelaPenque, Deborah2013-02-12T16:52:01Z2012-102012-10-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10400.18/1312enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-26T14:27:35Zoai:repositorio.insa.pt:10400.18/1312Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T21:42:33.070503Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Optimizing the discovery of predictors of vaso-occlusion in sickle-cell disease by proteomics
title Optimizing the discovery of predictors of vaso-occlusion in sickle-cell disease by proteomics
spellingShingle Optimizing the discovery of predictors of vaso-occlusion in sickle-cell disease by proteomics
Lavinha, João
Sickle Cell Disease
Plasma Proteome
Genómica Funcional e Estrutural
title_short Optimizing the discovery of predictors of vaso-occlusion in sickle-cell disease by proteomics
title_full Optimizing the discovery of predictors of vaso-occlusion in sickle-cell disease by proteomics
title_fullStr Optimizing the discovery of predictors of vaso-occlusion in sickle-cell disease by proteomics
title_full_unstemmed Optimizing the discovery of predictors of vaso-occlusion in sickle-cell disease by proteomics
title_sort Optimizing the discovery of predictors of vaso-occlusion in sickle-cell disease by proteomics
author Lavinha, João
author_facet Lavinha, João
Charro, Nuno
Vaz, Fátima
Morais, Anabela
Penque, Deborah
author_role author
author2 Charro, Nuno
Vaz, Fátima
Morais, Anabela
Penque, Deborah
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Lavinha, João
Charro, Nuno
Vaz, Fátima
Morais, Anabela
Penque, Deborah
dc.subject.por.fl_str_mv Sickle Cell Disease
Plasma Proteome
Genómica Funcional e Estrutural
topic Sickle Cell Disease
Plasma Proteome
Genómica Funcional e Estrutural
description Painful crises are the major sickle-cell disease (SCD) clinical manifestation probably due to significant increase in dense red blood cells (RBC) and reduction of their ability to pass through capillaries. Using proteomic strategies (see figure below), we aimed to discover novel SCD prognosis biomarkers as early predictors of the transition from steady-state to vaso-occlusive crises thus, allowing a prompt and specific therapeutic intervention.
publishDate 2012
dc.date.none.fl_str_mv 2012-10
2012-10-01T00:00:00Z
2013-02-12T16:52:01Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/1312
url http://hdl.handle.net/10400.18/1312
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Nacional de Saúde Doutor Ricardo Jorge, IP
publisher.none.fl_str_mv Instituto Nacional de Saúde Doutor Ricardo Jorge, IP
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833599389579345920

Similar Items