Plasma and red blood cell proteome in sickle-cell disease

Detalhes bibliográficos
Autor(a) principal: Charro, Nuno
Data de Publicação: 2012
Outros Autores: Vaz, Fatima, Morais, Anabela, Lavinha, João, Penque, Deborah
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10400.18/1285
Resumo: Sickle-cell disease (SCD) is a clinically heterogeneous autosomal recessive monogenic chronic anaemia characterized by recurrent episodes of severe vaso-occlusion, haemolysis and infection. Painful crises are the major SCD clinical manifestation probably due to significant increase in dense red blood cells (RBC) and reduction of their ability to pass through capillaries. Using proteomic strategies, we aim to discover novel and better SCD prognosis biomarkers as early predictors of the transition from steady-state to crisis namely vaso-occlusive episodes, thus, allowing a prompt and specific therapeutic intervention
id RCAP_903d1333a52c09d2a9abdebea7bbc424
oai_identifier_str oai:repositorio.insa.pt:10400.18/1285
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Plasma and red blood cell proteome in sickle-cell diseaseSCDPlasma ProteomeGenómica Funcional e EstruturalSickle-cell disease (SCD) is a clinically heterogeneous autosomal recessive monogenic chronic anaemia characterized by recurrent episodes of severe vaso-occlusion, haemolysis and infection. Painful crises are the major SCD clinical manifestation probably due to significant increase in dense red blood cells (RBC) and reduction of their ability to pass through capillaries. Using proteomic strategies, we aim to discover novel and better SCD prognosis biomarkers as early predictors of the transition from steady-state to crisis namely vaso-occlusive episodes, thus, allowing a prompt and specific therapeutic interventionRepositório Científico do Instituto Nacional de SaúdeCharro, NunoVaz, FatimaMorais, AnabelaLavinha, JoãoPenque, Deborah2013-02-12T12:53:30Z2012-072012-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10400.18/1285enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-26T14:13:00Zoai:repositorio.insa.pt:10400.18/1285Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T21:27:26.745498Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Plasma and red blood cell proteome in sickle-cell disease
title Plasma and red blood cell proteome in sickle-cell disease
spellingShingle Plasma and red blood cell proteome in sickle-cell disease
Charro, Nuno
SCD
Plasma Proteome
Genómica Funcional e Estrutural
title_short Plasma and red blood cell proteome in sickle-cell disease
title_full Plasma and red blood cell proteome in sickle-cell disease
title_fullStr Plasma and red blood cell proteome in sickle-cell disease
title_full_unstemmed Plasma and red blood cell proteome in sickle-cell disease
title_sort Plasma and red blood cell proteome in sickle-cell disease
author Charro, Nuno
author_facet Charro, Nuno
Vaz, Fatima
Morais, Anabela
Lavinha, João
Penque, Deborah
author_role author
author2 Vaz, Fatima
Morais, Anabela
Lavinha, João
Penque, Deborah
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Charro, Nuno
Vaz, Fatima
Morais, Anabela
Lavinha, João
Penque, Deborah
dc.subject.por.fl_str_mv SCD
Plasma Proteome
Genómica Funcional e Estrutural
topic SCD
Plasma Proteome
Genómica Funcional e Estrutural
description Sickle-cell disease (SCD) is a clinically heterogeneous autosomal recessive monogenic chronic anaemia characterized by recurrent episodes of severe vaso-occlusion, haemolysis and infection. Painful crises are the major SCD clinical manifestation probably due to significant increase in dense red blood cells (RBC) and reduction of their ability to pass through capillaries. Using proteomic strategies, we aim to discover novel and better SCD prognosis biomarkers as early predictors of the transition from steady-state to crisis namely vaso-occlusive episodes, thus, allowing a prompt and specific therapeutic intervention
publishDate 2012
dc.date.none.fl_str_mv 2012-07
2012-07-01T00:00:00Z
2013-02-12T12:53:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/1285
url http://hdl.handle.net/10400.18/1285
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833599286134177792

Registros relacionados