The right time for senescence

Bibliographic Details
Main Author: De-Carvalho, Diogo Paramos
Publication Date: 2021
Other Authors: Jacinto, Antonio, Saúde, Leonor
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/130893
Summary: Funding: We are truly grateful to Pedro Sousa-Vitor, Miguel Godinho-Ferreira, and Mariana AscençãoFerreira for critical reading of the manuscript. This work was supported by a FCT PhD Fellowship (PD/BD/105770/2014) to DPC, and co-funded by the FCT (PTDC/MED-NEU/30428/2017), 'la Caixa' Banking Foundation and FCT, IP, under project code HR18-00187 and SCML Melo e Castro Award (MC36-2020).
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spelling The right time for senescenceNeuroscience(all)Biochemistry, Genetics and Molecular Biology(all)Immunology and Microbiology(all)SDG 3 - Good Health and Well-beingFunding: We are truly grateful to Pedro Sousa-Vitor, Miguel Godinho-Ferreira, and Mariana AscençãoFerreira for critical reading of the manuscript. This work was supported by a FCT PhD Fellowship (PD/BD/105770/2014) to DPC, and co-funded by the FCT (PTDC/MED-NEU/30428/2017), 'la Caixa' Banking Foundation and FCT, IP, under project code HR18-00187 and SCML Melo e Castro Award (MC36-2020).Cellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cellular defense mechanism in response to stress, implicated in a wide spectrum of biolog­ical processes like tissue remodelling, injury and cancer. The development of new tools to study senescence in vivo paved the way to uncover its functional roles in various frameworks, which are sometimes hard to reconcile. Here, we review the functional impact of senescent cells on different organismal contexts. We provide updated insights on the role of senescent cells in tissue repair and regeneration, in which they essentially modulate the levels of fibrosis and inflammation, discussing how “time” seems to be the key maestro of their effects. Finally, we overview the current clinical research landscape to target senescent cells and contemplate its repercussions on this fast-evolving field.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNDe-Carvalho, Diogo ParamosJacinto, AntonioSaúde, Leonor2022-01-15T03:30:19Z2021-112021-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/130893eng2050-084XPURE: 35482606https://doi.org/10.7554/eLife.72449info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:58:09Zoai:run.unl.pt:10362/130893Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:29:22.504572Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The right time for senescence
title The right time for senescence
spellingShingle The right time for senescence
De-Carvalho, Diogo Paramos
Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
SDG 3 - Good Health and Well-being
title_short The right time for senescence
title_full The right time for senescence
title_fullStr The right time for senescence
title_full_unstemmed The right time for senescence
title_sort The right time for senescence
author De-Carvalho, Diogo Paramos
author_facet De-Carvalho, Diogo Paramos
Jacinto, Antonio
Saúde, Leonor
author_role author
author2 Jacinto, Antonio
Saúde, Leonor
author2_role author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv De-Carvalho, Diogo Paramos
Jacinto, Antonio
Saúde, Leonor
dc.subject.por.fl_str_mv Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
SDG 3 - Good Health and Well-being
topic Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
SDG 3 - Good Health and Well-being
description Funding: We are truly grateful to Pedro Sousa-Vitor, Miguel Godinho-Ferreira, and Mariana AscençãoFerreira for critical reading of the manuscript. This work was supported by a FCT PhD Fellowship (PD/BD/105770/2014) to DPC, and co-funded by the FCT (PTDC/MED-NEU/30428/2017), 'la Caixa' Banking Foundation and FCT, IP, under project code HR18-00187 and SCML Melo e Castro Award (MC36-2020).
publishDate 2021
dc.date.none.fl_str_mv 2021-11
2021-11-01T00:00:00Z
2022-01-15T03:30:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/130893
url http://hdl.handle.net/10362/130893
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2050-084X
PURE: 35482606
https://doi.org/10.7554/eLife.72449
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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