Cadherins Glycans in Cancer: Sweet Players in a Bitter Process

Bibliographic Details
Main Author: Carvalho, S
Publication Date: 2016
Other Authors: Reis, CA, Pinho, SS
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://repositorio-aberto.up.pt/handle/10216/118209
Summary: Cadherins are key components in tissue morphogenesis and architecture, contributing to the establishment of cohesive cell adhesion. Reduced cellular adhesiveness as a result of cadherin dysfunction is a defining feature of cancer. During tumor development and progression, major changes in the glycan repertoire of cancer cells take place, affecting the stability, trafficking, and cell-adhesion properties of cadherins. Importantly, the different glycoforms of cadherins are promising biomarkers, with potential clinical application to improve the management of patients, and constitute targets for the development of new therapies. This review discusses the most recent insights on the impact of glycan structure on the regulation of cadherin function in cancer, and provides a perspective on how cadherin glycans constitute tumor biomarkers and potential therapeutic targets.
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spelling Cadherins Glycans in Cancer: Sweet Players in a Bitter ProcessAnimalsBiomarkers, Tumor/metabolismCadherins/metabolismCell AdhesionGlycosylationHumansNeoplasms/metabolismNeoplasms/pathologyPolysaccharides/metabolismCadherins are key components in tissue morphogenesis and architecture, contributing to the establishment of cohesive cell adhesion. Reduced cellular adhesiveness as a result of cadherin dysfunction is a defining feature of cancer. During tumor development and progression, major changes in the glycan repertoire of cancer cells take place, affecting the stability, trafficking, and cell-adhesion properties of cadherins. Importantly, the different glycoforms of cadherins are promising biomarkers, with potential clinical application to improve the management of patients, and constitute targets for the development of new therapies. This review discusses the most recent insights on the impact of glycan structure on the regulation of cadherin function in cancer, and provides a perspective on how cadherin glycans constitute tumor biomarkers and potential therapeutic targets.Cell Press20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://repositorio-aberto.up.pt/handle/10216/118209eng2405-803310.1016/j.trecan.2016.08.003Carvalho, SReis, CAPinho, SSinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-27T17:58:12Zoai:repositorio-aberto.up.pt:10216/118209Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T22:32:47.421677Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Cadherins Glycans in Cancer: Sweet Players in a Bitter Process
title Cadherins Glycans in Cancer: Sweet Players in a Bitter Process
spellingShingle Cadherins Glycans in Cancer: Sweet Players in a Bitter Process
Carvalho, S
Animals
Biomarkers, Tumor/metabolism
Cadherins/metabolism
Cell Adhesion
Glycosylation
Humans
Neoplasms/metabolism
Neoplasms/pathology
Polysaccharides/metabolism
title_short Cadherins Glycans in Cancer: Sweet Players in a Bitter Process
title_full Cadherins Glycans in Cancer: Sweet Players in a Bitter Process
title_fullStr Cadherins Glycans in Cancer: Sweet Players in a Bitter Process
title_full_unstemmed Cadherins Glycans in Cancer: Sweet Players in a Bitter Process
title_sort Cadherins Glycans in Cancer: Sweet Players in a Bitter Process
author Carvalho, S
author_facet Carvalho, S
Reis, CA
Pinho, SS
author_role author
author2 Reis, CA
Pinho, SS
author2_role author
author
dc.contributor.author.fl_str_mv Carvalho, S
Reis, CA
Pinho, SS
dc.subject.por.fl_str_mv Animals
Biomarkers, Tumor/metabolism
Cadherins/metabolism
Cell Adhesion
Glycosylation
Humans
Neoplasms/metabolism
Neoplasms/pathology
Polysaccharides/metabolism
topic Animals
Biomarkers, Tumor/metabolism
Cadherins/metabolism
Cell Adhesion
Glycosylation
Humans
Neoplasms/metabolism
Neoplasms/pathology
Polysaccharides/metabolism
description Cadherins are key components in tissue morphogenesis and architecture, contributing to the establishment of cohesive cell adhesion. Reduced cellular adhesiveness as a result of cadherin dysfunction is a defining feature of cancer. During tumor development and progression, major changes in the glycan repertoire of cancer cells take place, affecting the stability, trafficking, and cell-adhesion properties of cadherins. Importantly, the different glycoforms of cadherins are promising biomarkers, with potential clinical application to improve the management of patients, and constitute targets for the development of new therapies. This review discusses the most recent insights on the impact of glycan structure on the regulation of cadherin function in cancer, and provides a perspective on how cadherin glycans constitute tumor biomarkers and potential therapeutic targets.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio-aberto.up.pt/handle/10216/118209
url https://repositorio-aberto.up.pt/handle/10216/118209
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2405-8033
10.1016/j.trecan.2016.08.003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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