Glycans as regulatory elements of the insulin/IGF system: Impact in cancer progression

Bibliographic Details
Main Author: Freitas-Junior, JCM
Publication Date: 2017
Other Authors: Andrade-da-Costa, J, Silva, M, Pinho, SS
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://repositorio-aberto.up.pt/handle/10216/118213
Summary: The insulin/insulin-like growth factor (IGF) system in mammals comprises a dynamic network of proteins that modulate several biological processes such as development, cell growth, metabolism, and aging. Dysregulation of the insulin/IGF system has major implications for several pathological conditions such as diabetes and cancer. Metabolic changes also culminate in aberrant glycosylation, which has been highlighted as a hallmark of cancer. Changes in glycosylation regulate every pathophysiological step of cancer progression including tumour cell-cell dissociation, cell migration, cell signaling and metastasis. This review discusses how the insulin/IGF system integrates with glycosylation alterations and impacts on cell behaviour, metabolism and drug resistance in cancer.
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network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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spelling Glycans as regulatory elements of the insulin/IGF system: Impact in cancer progressionAnimalsGlycosylationHumansInsulin/geneticsInsulin/metabolismInsulin-Like Growth Factor I/geneticsInsulin-Like Growth Factor I/metabolismNeoplasms/geneticsNeoplasms/metabolismNeoplasms/pathologyPolysaccharides/metabolismRegulatory Sequences, Nucleic Acid/geneticsSignal Transduction/geneticsSignal Transduction/physiologyThe insulin/insulin-like growth factor (IGF) system in mammals comprises a dynamic network of proteins that modulate several biological processes such as development, cell growth, metabolism, and aging. Dysregulation of the insulin/IGF system has major implications for several pathological conditions such as diabetes and cancer. Metabolic changes also culminate in aberrant glycosylation, which has been highlighted as a hallmark of cancer. Changes in glycosylation regulate every pathophysiological step of cancer progression including tumour cell-cell dissociation, cell migration, cell signaling and metastasis. This review discusses how the insulin/IGF system integrates with glycosylation alterations and impacts on cell behaviour, metabolism and drug resistance in cancer.MDPI20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://repositorio-aberto.up.pt/handle/10216/118213eng1661-659610.3390/ijms18091921Freitas-Junior, JCMAndrade-da-Costa, JSilva, MPinho, SSinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-27T18:22:03Zoai:repositorio-aberto.up.pt:10216/118213Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T22:46:36.256912Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Glycans as regulatory elements of the insulin/IGF system: Impact in cancer progression
title Glycans as regulatory elements of the insulin/IGF system: Impact in cancer progression
spellingShingle Glycans as regulatory elements of the insulin/IGF system: Impact in cancer progression
Freitas-Junior, JCM
Animals
Glycosylation
Humans
Insulin/genetics
Insulin/metabolism
Insulin-Like Growth Factor I/genetics
Insulin-Like Growth Factor I/metabolism
Neoplasms/genetics
Neoplasms/metabolism
Neoplasms/pathology
Polysaccharides/metabolism
Regulatory Sequences, Nucleic Acid/genetics
Signal Transduction/genetics
Signal Transduction/physiology
title_short Glycans as regulatory elements of the insulin/IGF system: Impact in cancer progression
title_full Glycans as regulatory elements of the insulin/IGF system: Impact in cancer progression
title_fullStr Glycans as regulatory elements of the insulin/IGF system: Impact in cancer progression
title_full_unstemmed Glycans as regulatory elements of the insulin/IGF system: Impact in cancer progression
title_sort Glycans as regulatory elements of the insulin/IGF system: Impact in cancer progression
author Freitas-Junior, JCM
author_facet Freitas-Junior, JCM
Andrade-da-Costa, J
Silva, M
Pinho, SS
author_role author
author2 Andrade-da-Costa, J
Silva, M
Pinho, SS
author2_role author
author
author
dc.contributor.author.fl_str_mv Freitas-Junior, JCM
Andrade-da-Costa, J
Silva, M
Pinho, SS
dc.subject.por.fl_str_mv Animals
Glycosylation
Humans
Insulin/genetics
Insulin/metabolism
Insulin-Like Growth Factor I/genetics
Insulin-Like Growth Factor I/metabolism
Neoplasms/genetics
Neoplasms/metabolism
Neoplasms/pathology
Polysaccharides/metabolism
Regulatory Sequences, Nucleic Acid/genetics
Signal Transduction/genetics
Signal Transduction/physiology
topic Animals
Glycosylation
Humans
Insulin/genetics
Insulin/metabolism
Insulin-Like Growth Factor I/genetics
Insulin-Like Growth Factor I/metabolism
Neoplasms/genetics
Neoplasms/metabolism
Neoplasms/pathology
Polysaccharides/metabolism
Regulatory Sequences, Nucleic Acid/genetics
Signal Transduction/genetics
Signal Transduction/physiology
description The insulin/insulin-like growth factor (IGF) system in mammals comprises a dynamic network of proteins that modulate several biological processes such as development, cell growth, metabolism, and aging. Dysregulation of the insulin/IGF system has major implications for several pathological conditions such as diabetes and cancer. Metabolic changes also culminate in aberrant glycosylation, which has been highlighted as a hallmark of cancer. Changes in glycosylation regulate every pathophysiological step of cancer progression including tumour cell-cell dissociation, cell migration, cell signaling and metastasis. This review discusses how the insulin/IGF system integrates with glycosylation alterations and impacts on cell behaviour, metabolism and drug resistance in cancer.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio-aberto.up.pt/handle/10216/118213
url https://repositorio-aberto.up.pt/handle/10216/118213
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-6596
10.3390/ijms18091921
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833599858484707328

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