Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer

Bibliographic Details
Main Author: Marcelo, Gonçalo A.
Publication Date: 2022
Other Authors: Galhano, Joana, Robalo, Tiago T., Cruz, Maria Margarida, Marcos, María D., Martínez-Máñez, Ramón, Duarte, Maria Paula, Capelo-Martínez, José Luis, Lodeiro, Carlos, Oliveira, Elisabete
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/150649
Summary: Funding Information: This work was funded by the Associate Laboratory for Green Chemistry—LAQV which is financed by national funds from the Scientific Society PROTEOMASS (Portugal) for funding support (General Funding Grant 2021). Publisher Copyright: © 2022 by the authors.
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spelling Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancerantimicrobialdrug deliveryhyperthermiamagneto-fluorescencemesoporous nanoparticlesopportunistic cancer-related bacteriaCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistrySDG 3 - Good Health and Well-beingFunding Information: This work was funded by the Associate Laboratory for Green Chemistry—LAQV which is financed by national funds from the Scientific Society PROTEOMASS (Portugal) for funding support (General Funding Grant 2021). Publisher Copyright: © 2022 by the authors.Cancer-related opportunistic bacterial infections are one major barrier for successful clinical therapies, often correlated to the production of genotoxic factors and higher cancer incidence. Although dual anticancer and antimicrobial therapies are a growing therapeutic fashion, they still fall short when it comes to specific delivery and local action in in vivo systems. Nanoparticles are seen as potential therapeutic vectors, be it by means of their intrinsic antibacterial properties and effective delivery capacity, or by means of their repeatedly reported modulation and maneuverability. Herein we report on the production of a biocompatible, antimicrobial magneto-fluorescent nanosystem (NANO3) for the delivery of a dual doxorubicin–ofloxacin formulation against cancer-related bacterial infections. The drug delivery capacity, rendered by its mesoporous silica matrix, is confirmed by the high loading capacity and stimuli-driven release of both drugs, with preference for tumor-like acidic media. The pH-dependent emission of its surface fluorescent SiQDs, provides an insight into NANO3 surface behavior and pore availability, with the SiQDs working as pore gates. Hyperthermia induces heat generation to febrile temperatures, doubling drug release. NANO3-loaded systems demonstrate significant antimicrobial activity, specifically after the application of hyperthermia conditions. NANO3 structure and antimicrobial properties confirm their potential use in a future dual anticancer and antimicrobial therapeutical vector, due to their drug loading capacity and their surface availability for further modification with bioactive, targeting species.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNMarcelo, Gonçalo A.Galhano, JoanaRobalo, Tiago T.Cruz, Maria MargaridaMarcos, María D.Martínez-Máñez, RamónDuarte, Maria PaulaCapelo-Martínez, José LuisLodeiro, CarlosOliveira, Elisabete2023-03-15T22:34:54Z2022-10-142022-10-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article21application/pdfhttp://hdl.handle.net/10362/150649eng1661-6596PURE: 55913551https://doi.org/10.3390/ijms232012287info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:10:02Zoai:run.unl.pt:10362/150649Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:40:41.327309Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer
title Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer
spellingShingle Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer
Marcelo, Gonçalo A.
antimicrobial
drug delivery
hyperthermia
magneto-fluorescence
mesoporous nanoparticles
opportunistic cancer-related bacteria
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
title_short Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer
title_full Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer
title_fullStr Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer
title_full_unstemmed Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer
title_sort Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer
author Marcelo, Gonçalo A.
author_facet Marcelo, Gonçalo A.
Galhano, Joana
Robalo, Tiago T.
Cruz, Maria Margarida
Marcos, María D.
Martínez-Máñez, Ramón
Duarte, Maria Paula
Capelo-Martínez, José Luis
Lodeiro, Carlos
Oliveira, Elisabete
author_role author
author2 Galhano, Joana
Robalo, Tiago T.
Cruz, Maria Margarida
Marcos, María D.
Martínez-Máñez, Ramón
Duarte, Maria Paula
Capelo-Martínez, José Luis
Lodeiro, Carlos
Oliveira, Elisabete
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Marcelo, Gonçalo A.
Galhano, Joana
Robalo, Tiago T.
Cruz, Maria Margarida
Marcos, María D.
Martínez-Máñez, Ramón
Duarte, Maria Paula
Capelo-Martínez, José Luis
Lodeiro, Carlos
Oliveira, Elisabete
dc.subject.por.fl_str_mv antimicrobial
drug delivery
hyperthermia
magneto-fluorescence
mesoporous nanoparticles
opportunistic cancer-related bacteria
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
topic antimicrobial
drug delivery
hyperthermia
magneto-fluorescence
mesoporous nanoparticles
opportunistic cancer-related bacteria
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
description Funding Information: This work was funded by the Associate Laboratory for Green Chemistry—LAQV which is financed by national funds from the Scientific Society PROTEOMASS (Portugal) for funding support (General Funding Grant 2021). Publisher Copyright: © 2022 by the authors.
publishDate 2022
dc.date.none.fl_str_mv 2022-10-14
2022-10-14T00:00:00Z
2023-03-15T22:34:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/150649
url http://hdl.handle.net/10362/150649
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-6596
PURE: 55913551
https://doi.org/10.3390/ijms232012287
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 21
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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