Engineered Liposomes in Interventional Theranostics of Solid Tumors

Bibliographic Details
Main Author: Kommineni, Nagavendra
Publication Date: 2023
Other Authors: Chaudhari, Ruchita, Conde, João, Tamburaci, Sedef, Cecen, Berivan, Chandra, Pranjal, Prasad, Rajendra
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/157009
Summary: Funding Information: R.P. thanks the director of IIT-BHU, Varanasi, U.P., for encouraging and providing the necessary facility and support and would also like to thank the school of biochemical engineering, IIT-BHU. N.K. would like to thank CBR, Population Council, for providing the Sheldon J. Segal Post-Doctoral Fellowship. P.C. acknowledges the support from the DST-funded I-DAPT Hub Foundation, IIT BHU [DST/NMICPS/TIH11/IIT(BHU)2020/02]. The authors thank Leander Corrie, Arun Butreddy, Sachin Kumar, and Qing He for reading this manuscript. J.C. acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). The author dedicates this article to Prof. Sanjiv Sam Gambhir, a molecular imaging scientist. All reproduced images and figures have been cited in this review. Publisher Copyright: © 2023 American Chemical Society.
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spelling Engineered Liposomes in Interventional Theranostics of Solid Tumorsinterventional theranosticliposomesnanoimagingsolid tumorsBiomaterialsBiomedical EngineeringSDG 3 - Good Health and Well-beingFunding Information: R.P. thanks the director of IIT-BHU, Varanasi, U.P., for encouraging and providing the necessary facility and support and would also like to thank the school of biochemical engineering, IIT-BHU. N.K. would like to thank CBR, Population Council, for providing the Sheldon J. Segal Post-Doctoral Fellowship. P.C. acknowledges the support from the DST-funded I-DAPT Hub Foundation, IIT BHU [DST/NMICPS/TIH11/IIT(BHU)2020/02]. The authors thank Leander Corrie, Arun Butreddy, Sachin Kumar, and Qing He for reading this manuscript. J.C. acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). The author dedicates this article to Prof. Sanjiv Sam Gambhir, a molecular imaging scientist. All reproduced images and figures have been cited in this review. Publisher Copyright: © 2023 American Chemical Society.Engineered liposomal nanoparticles have unique characteristics as cargo carriers in cancer care and therapeutics. Liposomal theranostics have shown significant progress in preclinical and clinical cancer models in the past few years. Liposomal hybrid systems have not only been approved by the FDA but have also reached the market level. Nanosized liposomes are clinically proven systems for delivering multiple therapeutic as well as imaging agents to the target sites in (i) cancer theranostics of solid tumors, (ii) image-guided therapeutics, and (iii) combination therapeutic applications. The choice of diagnostics and therapeutics can intervene in the theranostics property of the engineered system. However, integrating imaging and therapeutics probes within lipid self-assembly “liposome” may compromise their overall theranostics performance. On the other hand, liposomal systems suffer from their fragile nature, site-selective tumor targeting, specific biodistribution and premature leakage of loaded cargo molecules before reaching the target site. Various engineering approaches, viz., grafting, conjugation, encapsulations, etc., have been investigated to overcome the aforementioned issues. It has been studied that surface-engineered liposomes demonstrate better tumor selectivity and improved therapeutic activity and retention in cells/or solid tumors. It should be noted that several other parameters like reproducibility, stability, smooth circulation, toxicity of vital organs, patient compliance, etc. must be addressed before using liposomal theranostics agents in solid tumors or clinical models. Herein, we have reviewed the importance and challenges of liposomal medicines in targeted cancer theranostics with their preclinical and clinical progress and a translational overview.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centre for Toxicogenomics and Human Health (ToxOmics)RUNKommineni, NagavendraChaudhari, RuchitaConde, JoãoTamburaci, SedefCecen, BerivanChandra, PranjalPrasad, Rajendra2023-08-29T22:17:39Z2023-08-142023-08-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/157009eng2373-9878PURE: 69583327https://doi.org/10.1021/acsbiomaterials.3c00510info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-26T01:40:54Zoai:run.unl.pt:10362/157009Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:44:13.955919Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Engineered Liposomes in Interventional Theranostics of Solid Tumors
title Engineered Liposomes in Interventional Theranostics of Solid Tumors
spellingShingle Engineered Liposomes in Interventional Theranostics of Solid Tumors
Kommineni, Nagavendra
interventional theranostic
liposomes
nanoimaging
solid tumors
Biomaterials
Biomedical Engineering
SDG 3 - Good Health and Well-being
title_short Engineered Liposomes in Interventional Theranostics of Solid Tumors
title_full Engineered Liposomes in Interventional Theranostics of Solid Tumors
title_fullStr Engineered Liposomes in Interventional Theranostics of Solid Tumors
title_full_unstemmed Engineered Liposomes in Interventional Theranostics of Solid Tumors
title_sort Engineered Liposomes in Interventional Theranostics of Solid Tumors
author Kommineni, Nagavendra
author_facet Kommineni, Nagavendra
Chaudhari, Ruchita
Conde, João
Tamburaci, Sedef
Cecen, Berivan
Chandra, Pranjal
Prasad, Rajendra
author_role author
author2 Chaudhari, Ruchita
Conde, João
Tamburaci, Sedef
Cecen, Berivan
Chandra, Pranjal
Prasad, Rajendra
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centre for Toxicogenomics and Human Health (ToxOmics)
RUN
dc.contributor.author.fl_str_mv Kommineni, Nagavendra
Chaudhari, Ruchita
Conde, João
Tamburaci, Sedef
Cecen, Berivan
Chandra, Pranjal
Prasad, Rajendra
dc.subject.por.fl_str_mv interventional theranostic
liposomes
nanoimaging
solid tumors
Biomaterials
Biomedical Engineering
SDG 3 - Good Health and Well-being
topic interventional theranostic
liposomes
nanoimaging
solid tumors
Biomaterials
Biomedical Engineering
SDG 3 - Good Health and Well-being
description Funding Information: R.P. thanks the director of IIT-BHU, Varanasi, U.P., for encouraging and providing the necessary facility and support and would also like to thank the school of biochemical engineering, IIT-BHU. N.K. would like to thank CBR, Population Council, for providing the Sheldon J. Segal Post-Doctoral Fellowship. P.C. acknowledges the support from the DST-funded I-DAPT Hub Foundation, IIT BHU [DST/NMICPS/TIH11/IIT(BHU)2020/02]. The authors thank Leander Corrie, Arun Butreddy, Sachin Kumar, and Qing He for reading this manuscript. J.C. acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). The author dedicates this article to Prof. Sanjiv Sam Gambhir, a molecular imaging scientist. All reproduced images and figures have been cited in this review. Publisher Copyright: © 2023 American Chemical Society.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-29T22:17:39Z
2023-08-14
2023-08-14T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
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url http://hdl.handle.net/10362/157009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2373-9878
PURE: 69583327
https://doi.org/10.1021/acsbiomaterials.3c00510
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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