Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

Bibliographic Details
Main Author: Barbacena, Pedro
Publication Date: 2022
Other Authors: Dominguez-Cejudo, Maria Angeles, Fonseca, Catarina, Gómez-González, Manuel, Faure, Laura M., Zarkada, Georgia, Pena, Andreia, Pezzarossa, Anna, Ramalho, Daniela, Giarratano, Ylenia, Ouarné, Marie, Barata, David, Fortunato, Isabela C., Henao Mišíková, Lenka, Mauldin, Ian, Carvalho, Yulia, Trepat, Xavier, Roca-Cusachs, Pere, Eichmann, Anne, Bernabeu, Miguel O., Franco, Claudio
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/54853
Summary: © 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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spelling Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retinaAngiogenesisCell polarityMechanobiologyMorphogenesisShear stress© 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Blood-vessel formation generates unique vascular patterns in each individual. The principles governing the apparent stochasticity of this process remain to be elucidated. Using mathematical methods, we find that the transition between two fundamental vascular morphogenetic programs-sprouting angiogenesis and vascular remodeling-is established by a shift of collective front-to-rear polarity of endothelial cells in the mouse retina. We demonstrate that the competition between biochemical (VEGFA) and mechanical (blood-flow-induced shear stress) cues controls this collective polarity shift. Shear stress increases tension at focal adhesions overriding VEGFA-driven collective polarization, which relies on tension at adherens junctions. We propose that vascular morphogenetic cues compete to regulate individual cell polarity and migration through tension shifts that translates into tissue-level emergent behaviors, ultimately leading to uniquely organized vascular patterns.Funding: European Research Council: C.A.F. (679368); X.T. (883739). European Commission: C.A.F. and M.O.B. (801423); X.T. and P.R.-C. (731957). H2020-MSCA-PF grants to M.G.-G. (797621) and M.O. (842498). Fondation LeDucq: C.A.F., A.E., and M.O.B. (17CVD03). EPSRC: M.O.B. (EP/T008806/1; EP/R029598/1). Fundação para a Ciência e Tecnologia: C.A.F. (PTDC/MED-PAT/31639/2017; PTDC/BIA-CEL/32180/2017; CEECIND/04251/2017). Spanish Ministry of Science and Innovation: P.R.-C. (PID2019-110298GB-I00); X.T. (PGC2018-099645-B-I00). Generalitat de Catalunya: X.T. and P.R.-C. (2017-SGR-1602). La Caixa Foundation: X.T. and P.R.-C. (LCF/PR/HR20/52400004). Fundació la Marató de TV3: X.T. (201903-30-31-32). EMBO: L.M.F. (ALTF 2-2018)ElsevierRepositório da Universidade de LisboaBarbacena, PedroDominguez-Cejudo, Maria AngelesFonseca, CatarinaGómez-González, ManuelFaure, Laura M.Zarkada, GeorgiaPena, AndreiaPezzarossa, AnnaRamalho, DanielaGiarratano, YleniaOuarné, MarieBarata, DavidFortunato, Isabela C.Henao Mišíková, LenkaMauldin, IanCarvalho, YuliaTrepat, XavierRoca-Cusachs, PereEichmann, AnneBernabeu, Miguel O.Franco, Claudio2022-10-21T15:26:10Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54853engDev Cell. 2022 Oct 10;57(19):2321-2333.e91534-580710.1016/j.devcel.2022.09.0021878-1551info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:50:34Zoai:repositorio.ulisboa.pt:10451/54853Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:26:31.632289Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina
title Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina
spellingShingle Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina
Barbacena, Pedro
Angiogenesis
Cell polarity
Mechanobiology
Morphogenesis
Shear stress
title_short Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina
title_full Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina
title_fullStr Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina
title_full_unstemmed Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina
title_sort Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina
author Barbacena, Pedro
author_facet Barbacena, Pedro
Dominguez-Cejudo, Maria Angeles
Fonseca, Catarina
Gómez-González, Manuel
Faure, Laura M.
Zarkada, Georgia
Pena, Andreia
Pezzarossa, Anna
Ramalho, Daniela
Giarratano, Ylenia
Ouarné, Marie
Barata, David
Fortunato, Isabela C.
Henao Mišíková, Lenka
Mauldin, Ian
Carvalho, Yulia
Trepat, Xavier
Roca-Cusachs, Pere
Eichmann, Anne
Bernabeu, Miguel O.
Franco, Claudio
author_role author
author2 Dominguez-Cejudo, Maria Angeles
Fonseca, Catarina
Gómez-González, Manuel
Faure, Laura M.
Zarkada, Georgia
Pena, Andreia
Pezzarossa, Anna
Ramalho, Daniela
Giarratano, Ylenia
Ouarné, Marie
Barata, David
Fortunato, Isabela C.
Henao Mišíková, Lenka
Mauldin, Ian
Carvalho, Yulia
Trepat, Xavier
Roca-Cusachs, Pere
Eichmann, Anne
Bernabeu, Miguel O.
Franco, Claudio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Barbacena, Pedro
Dominguez-Cejudo, Maria Angeles
Fonseca, Catarina
Gómez-González, Manuel
Faure, Laura M.
Zarkada, Georgia
Pena, Andreia
Pezzarossa, Anna
Ramalho, Daniela
Giarratano, Ylenia
Ouarné, Marie
Barata, David
Fortunato, Isabela C.
Henao Mišíková, Lenka
Mauldin, Ian
Carvalho, Yulia
Trepat, Xavier
Roca-Cusachs, Pere
Eichmann, Anne
Bernabeu, Miguel O.
Franco, Claudio
dc.subject.por.fl_str_mv Angiogenesis
Cell polarity
Mechanobiology
Morphogenesis
Shear stress
topic Angiogenesis
Cell polarity
Mechanobiology
Morphogenesis
Shear stress
description © 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
publishDate 2022
dc.date.none.fl_str_mv 2022-10-21T15:26:10Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/54853
url http://hdl.handle.net/10451/54853
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Dev Cell. 2022 Oct 10;57(19):2321-2333.e9
1534-5807
10.1016/j.devcel.2022.09.002
1878-1551
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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