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Endothelial cells on the move: dynamics in vascular morphogenesis and disease

Bibliographic Details
Main Author: Fonseca, Catarina
Publication Date: 2020
Other Authors: Barbacena, Pedro, Franco, Claudio
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/49188
Summary: © 2020 The authors 2020. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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spelling Endothelial cells on the move: dynamics in vascular morphogenesis and diseaseAngiogenesisCell migrationCell polarityVascular diseaseVascular remodelling© 2020 The authors 2020. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.The vascular system is a hierarchically organized network of blood vessels that play crucial roles in embryogenesis, homeostasis and disease. Blood vessels are built by endothelial cells - the cells lining the interior of blood vessels - through a process named vascular morphogenesis. Endothelial cells react to different biomechanical signals in their environment by adjusting their behavior to: (1) invade, proliferate and fuse to form new vessels (angiogenesis); (2) remodel, regress and establish a hierarchy in the network (patterning); and (3) maintain network stability (quiescence). Each step involves the coordination of endothelial cell differentiation, proliferation, polarity, migration, rearrangements and shape changes to ensure network integrity and an efficient barrier between blood and tissues. In this review, we highlighted the relevance and the mechanisms involving endothelial cell migration during different steps of vascular morphogenesis. We further present evidence on how impaired endothelial cell dynamics can contribute to pathology.C A F was supported by European Research Council Starting Grant (AXIAL.EC; 679368), the Fundação para a Ciência e a Tecnologia funding (grants: IF/00412/2012; EXPL/BEX-BCM/2258/2013; PTDC/MED-PAT/31639/2017; PTDC/BIA-CEL/32180/2017), and a grant from the Fondation Leducq (17CVD03).Bioscientifica Ltd.Repositório da Universidade de LisboaFonseca, CatarinaBarbacena, PedroFranco, Claudio2021-07-28T14:03:39Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49188engVasc Biol. 2020 Jul 2;2(1):H29-H43.10.1530/VB-20-00072516-5658info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:36:07Zoai:repositorio.ulisboa.pt:10451/49188Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:16:44.858510Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Endothelial cells on the move: dynamics in vascular morphogenesis and disease
title Endothelial cells on the move: dynamics in vascular morphogenesis and disease
spellingShingle Endothelial cells on the move: dynamics in vascular morphogenesis and disease
Fonseca, Catarina
Angiogenesis
Cell migration
Cell polarity
Vascular disease
Vascular remodelling
title_short Endothelial cells on the move: dynamics in vascular morphogenesis and disease
title_full Endothelial cells on the move: dynamics in vascular morphogenesis and disease
title_fullStr Endothelial cells on the move: dynamics in vascular morphogenesis and disease
title_full_unstemmed Endothelial cells on the move: dynamics in vascular morphogenesis and disease
title_sort Endothelial cells on the move: dynamics in vascular morphogenesis and disease
author Fonseca, Catarina
author_facet Fonseca, Catarina
Barbacena, Pedro
Franco, Claudio
author_role author
author2 Barbacena, Pedro
Franco, Claudio
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Fonseca, Catarina
Barbacena, Pedro
Franco, Claudio
dc.subject.por.fl_str_mv Angiogenesis
Cell migration
Cell polarity
Vascular disease
Vascular remodelling
topic Angiogenesis
Cell migration
Cell polarity
Vascular disease
Vascular remodelling
description © 2020 The authors 2020. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-07-28T14:03:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49188
url http://hdl.handle.net/10451/49188
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Vasc Biol. 2020 Jul 2;2(1):H29-H43.
10.1530/VB-20-0007
2516-5658
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Bioscientifica Ltd.
publisher.none.fl_str_mv Bioscientifica Ltd.
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833601649347657728

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