Gold Nanoconjugates for miRNA Modulation in Cancer Therapy

Detalhes bibliográficos
Autor(a) principal: Sousa, Diana P.
Data de Publicação: 2022
Outros Autores: Conde, João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10362/143308
Resumo: Funding This work was supported by the FCT PhD Scholarship (2020.06638.BD, Diana P. Sousa) and by the European Research Council Starting Grant ERC-StG-2019-848325 (2019−2024, João Conde).
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spelling Gold Nanoconjugates for miRNA Modulation in Cancer TherapyFrom miRNA Silencing to miRNA MimicsCancerCancer therapyGene therapyGoldNanoparticlesSDG 3 - Good Health and Well-beingFunding This work was supported by the FCT PhD Scholarship (2020.06638.BD, Diana P. Sousa) and by the European Research Council Starting Grant ERC-StG-2019-848325 (2019−2024, João Conde).Cancer is a major healthcare burden and cause of death worldwide, with an estimated 19.3 million new cancer cases and 10 million cancer deaths globally only in 2020. While several anticancer therapeutics are available to date, many of these still show low treatment efficacy and high off-target effects and adverse reactions. This prompts a serious need to develop novel therapies that can decrease the side effects and increase treatment efficacy. MicroRNAs (miRNAs) can have a role in tumor development and progression, making them important targets for the improvement of anticancer therapies. In this context, gold nanoparticles have been widely studied for different clinical applications due to their biocompatibility and possibility of customization, and gold nanoconjugates targeting miRNAs are being developed for cancer diagnosis and treatment. Here we summarize the research developed so far and how it can contribute to cancer treatment, discuss how it can be improved, and present the current challenges and future perspectives on their design and application.Centre for Toxicogenomics and Human Health (ToxOmics)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSousa, Diana P.Conde, João2022-08-25T22:21:23Z2022-08-132022-08-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/143308eng2694-2461PURE: 46066901https://doi.org/10.1021/acsmaterialsau.2c00042info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-26T01:40:22Zoai:run.unl.pt:10362/143308Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:35:24.165067Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Gold Nanoconjugates for miRNA Modulation in Cancer Therapy
From miRNA Silencing to miRNA Mimics
title Gold Nanoconjugates for miRNA Modulation in Cancer Therapy
spellingShingle Gold Nanoconjugates for miRNA Modulation in Cancer Therapy
Sousa, Diana P.
Cancer
Cancer therapy
Gene therapy
Gold
Nanoparticles
SDG 3 - Good Health and Well-being
title_short Gold Nanoconjugates for miRNA Modulation in Cancer Therapy
title_full Gold Nanoconjugates for miRNA Modulation in Cancer Therapy
title_fullStr Gold Nanoconjugates for miRNA Modulation in Cancer Therapy
title_full_unstemmed Gold Nanoconjugates for miRNA Modulation in Cancer Therapy
title_sort Gold Nanoconjugates for miRNA Modulation in Cancer Therapy
author Sousa, Diana P.
author_facet Sousa, Diana P.
Conde, João
author_role author
author2 Conde, João
author2_role author
dc.contributor.none.fl_str_mv Centre for Toxicogenomics and Human Health (ToxOmics)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Sousa, Diana P.
Conde, João
dc.subject.por.fl_str_mv Cancer
Cancer therapy
Gene therapy
Gold
Nanoparticles
SDG 3 - Good Health and Well-being
topic Cancer
Cancer therapy
Gene therapy
Gold
Nanoparticles
SDG 3 - Good Health and Well-being
description Funding This work was supported by the FCT PhD Scholarship (2020.06638.BD, Diana P. Sousa) and by the European Research Council Starting Grant ERC-StG-2019-848325 (2019−2024, João Conde).
publishDate 2022
dc.date.none.fl_str_mv 2022-08-25T22:21:23Z
2022-08-13
2022-08-13T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/143308
url http://hdl.handle.net/10362/143308
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2694-2461
PURE: 46066901
https://doi.org/10.1021/acsmaterialsau.2c00042
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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repository.mail.fl_str_mv info@rcaap.pt
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