5-year follow-up of spinal and sacroiliac MRI abnormalities in early axial spondyloarthritis

Bibliographic Details
Main Author: Madari, Queeny
Publication Date: 2020
Other Authors: Sepriano, Alexandre, Ramiro, Sofia, Molto, Anna, Claudepierre, Pascal, Wendling, Daniel, Dougados, Maxime, Van Der Heijde, Desirée, Van Gaalen, Floris A.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/92991
Summary: Funding: g Devenir des Spondyloarthropathies Indifférenciées Récentes (DESIR) is financially supported by an unrestricted grant from Pfizer. AS is supported by a doctoral grant from 'Fundação para a Ciência e Tecnologia' (SFRH/ BD/108246/2015). The DESIR study is conducted as a Programme Hospitalier de Recherche Clinique with Assistance Publique Hopitaux de Paris as the sponsor. The DESIR study is also under the umbrella of the French Society of Rheumatology, which financially supports the cohort. An unrestricted grant from Pfizer as been allocated for the first 10 years.
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spelling 5-year follow-up of spinal and sacroiliac MRI abnormalities in early axial spondyloarthritisData from the DESIR cohortankylosing spondylitisMRIspondyloarthritisImmunology and AllergyRheumatologyImmunologySDG 3 - Good Health and Well-beingFunding: g Devenir des Spondyloarthropathies Indifférenciées Récentes (DESIR) is financially supported by an unrestricted grant from Pfizer. AS is supported by a doctoral grant from 'Fundação para a Ciência e Tecnologia' (SFRH/ BD/108246/2015). The DESIR study is conducted as a Programme Hospitalier de Recherche Clinique with Assistance Publique Hopitaux de Paris as the sponsor. The DESIR study is also under the umbrella of the French Society of Rheumatology, which financially supports the cohort. An unrestricted grant from Pfizer as been allocated for the first 10 years.Objective To study changes on MRI of the spine and sacroiliac joint (SIJ) in early axial spondyloarthritis (axSpA) over time. Methods In the Devenir des Spondyloarthropathies Indifférenciées Récentes cohort, MRI-spine and MRI-SIJ at baseline and 2 and 5 years were scored by central readers for bone marrow oedema (BME), fatty lesions, erosions, sclerosis, ankylosis and spinal bone spurs. The average mean number of lesions was reported or the agreement of ≥2 out of 3 readers for binary outcomes. Net progression was calculated by subtracting the patients that a € improved' from those that a € worsened' divided by the total number of patients. Results Over 5 years, in 155 patients with axSpA (mean age 33.5 (SD 8.9) years, symptom duration 1.4 (0.8) years, 63% human leucocyte antigen+, 14% modified New York+), BME on MRI-SIJ decreased by a mean Spondyloarthritis Research Consortium of Canada score of 1.4 (SD 6.5) (p=0.009). The largest BME decrease was observed in patients using biological disease-modifying antirheumatic drugs at 5 years. Spinal BME increased by 0.3 (4.6) (p=0.41). Fatty lesions and/or erosions on MRI-SIJ increased by a mean of 1.0 (SD 2.6) (p<0.001). Spinal fatty lesions and/or erosions increased by 0.2 (SD 0.5) (p<0.001). Compared with baseline, at 5 years, 7.3% less patients had BME on MRI-SIJ according to the Assessment of Spondyloarthritis International Society definition, while 6.6% more patients had ≥5 fatty lesions and/or erosions. At 5 years, 0.7% less patients had ≥5 spinal BME lesions and 0.7% less patients had ≥5 spinal fatty lesions. Conclusion Over 5 years, BME on MRI-SIJ decreased and spinal BME remained similar, but numerically, little progression of structural lesions on MRI of the SIJ and spine was seen.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMadari, QueenySepriano, AlexandreRamiro, SofiaMolto, AnnaClaudepierre, PascalWendling, DanielDougados, MaximeVan Der Heijde, DesiréeVan Gaalen, Floris A.2020-02-18T23:33:50Z2020-02-052020-02-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/92991eng2044-6055PURE: 16900481https://doi.org/10.1136/rmdopen-2019-001093info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:43:34Zoai:run.unl.pt:10362/92991Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:14:52.033481Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv 5-year follow-up of spinal and sacroiliac MRI abnormalities in early axial spondyloarthritis
Data from the DESIR cohort
title 5-year follow-up of spinal and sacroiliac MRI abnormalities in early axial spondyloarthritis
spellingShingle 5-year follow-up of spinal and sacroiliac MRI abnormalities in early axial spondyloarthritis
Madari, Queeny
ankylosing spondylitis
MRI
spondyloarthritis
Immunology and Allergy
Rheumatology
Immunology
SDG 3 - Good Health and Well-being
title_short 5-year follow-up of spinal and sacroiliac MRI abnormalities in early axial spondyloarthritis
title_full 5-year follow-up of spinal and sacroiliac MRI abnormalities in early axial spondyloarthritis
title_fullStr 5-year follow-up of spinal and sacroiliac MRI abnormalities in early axial spondyloarthritis
title_full_unstemmed 5-year follow-up of spinal and sacroiliac MRI abnormalities in early axial spondyloarthritis
title_sort 5-year follow-up of spinal and sacroiliac MRI abnormalities in early axial spondyloarthritis
author Madari, Queeny
author_facet Madari, Queeny
Sepriano, Alexandre
Ramiro, Sofia
Molto, Anna
Claudepierre, Pascal
Wendling, Daniel
Dougados, Maxime
Van Der Heijde, Desirée
Van Gaalen, Floris A.
author_role author
author2 Sepriano, Alexandre
Ramiro, Sofia
Molto, Anna
Claudepierre, Pascal
Wendling, Daniel
Dougados, Maxime
Van Der Heijde, Desirée
Van Gaalen, Floris A.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Madari, Queeny
Sepriano, Alexandre
Ramiro, Sofia
Molto, Anna
Claudepierre, Pascal
Wendling, Daniel
Dougados, Maxime
Van Der Heijde, Desirée
Van Gaalen, Floris A.
dc.subject.por.fl_str_mv ankylosing spondylitis
MRI
spondyloarthritis
Immunology and Allergy
Rheumatology
Immunology
SDG 3 - Good Health and Well-being
topic ankylosing spondylitis
MRI
spondyloarthritis
Immunology and Allergy
Rheumatology
Immunology
SDG 3 - Good Health and Well-being
description Funding: g Devenir des Spondyloarthropathies Indifférenciées Récentes (DESIR) is financially supported by an unrestricted grant from Pfizer. AS is supported by a doctoral grant from 'Fundação para a Ciência e Tecnologia' (SFRH/ BD/108246/2015). The DESIR study is conducted as a Programme Hospitalier de Recherche Clinique with Assistance Publique Hopitaux de Paris as the sponsor. The DESIR study is also under the umbrella of the French Society of Rheumatology, which financially supports the cohort. An unrestricted grant from Pfizer as been allocated for the first 10 years.
publishDate 2020
dc.date.none.fl_str_mv 2020-02-18T23:33:50Z
2020-02-05
2020-02-05T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/92991
url http://hdl.handle.net/10362/92991
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2044-6055
PURE: 16900481
https://doi.org/10.1136/rmdopen-2019-001093
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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