Structural insights in mammalian sialyltransferases and fucosyltransferases

Bibliographic Details
Main Author: Grewal, Ravneet Kaur
Publication Date: 2021
Other Authors: Shaikh, Abdul Rajjak, Gorle, Suresh, Kaur, Manjeet, Videira, Paula Alexendra, Cavallo, Luigi, Chawla, Mohit
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/124893
Summary: Funding Information: The APC was funded by King Abdullah University of Science and Technology. M.C.: L.C. and A.R.S. acknowledge the King Abdullah University of Science and Technology (KAUST) for support. We thank Romina Oliva, University of Parthenope (Naples), for helpful comments. Thanks to the STEMskills Research and Education Lab team members for support.
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spelling Structural insights in mammalian sialyltransferases and fucosyltransferasesWe have come a long way, but it is still a long way downDrug designFucosyltransferaseGlyocosyltransferases in cancerSialyltransferaseAnalytical ChemistryChemistry (miscellaneous)Molecular MedicinePharmaceutical ScienceDrug DiscoveryPhysical and Theoretical ChemistryOrganic ChemistrySDG 3 - Good Health and Well-beingFunding Information: The APC was funded by King Abdullah University of Science and Technology. M.C.: L.C. and A.R.S. acknowledge the King Abdullah University of Science and Technology (KAUST) for support. We thank Romina Oliva, University of Parthenope (Naples), for helpful comments. Thanks to the STEMskills Research and Education Lab team members for support.Mammalian cell surfaces are modified with complex arrays of glycans that play major roles in health and disease. Abnormal glycosylation is a hallmark of cancer; terminal sialic acid and fucose in particular have high levels in tumor cells, with positive implications for malignancy. Increased sialylation and fucosylation are due to the upregulation of a set of sialyltransferases (STs) and fucosyltransferases (FUTs), which are potential drug targets in cancer. In the past, several advances in glycostructural biology have been made with the determination of crystal structures of several important STs and FUTs in mammals. Additionally, how the independent evolution of STs and FUTs occurred with a limited set of global folds and the diverse modular ability of catalytic domains toward substrates has been elucidated. This review highlights advances in the understanding of the structural architecture, substrate binding interactions, and catalysis of STs and FUTs in mammals. While this general understanding is emerging, use of this information to design inhibitors of STs and FUTs will be helpful in providing further insights into their role in the manifestation of cancer and developing targeted therapeutics in cancer.DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitRUNGrewal, Ravneet KaurShaikh, Abdul RajjakGorle, SureshKaur, ManjeetVideira, Paula AlexendraCavallo, LuigiChawla, Mohit2021-09-21T02:07:51Z2021-09-012021-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/124893eng1420-3049PURE: 33717185https://doi.org/10.3390/molecules26175203info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:56:14Zoai:run.unl.pt:10362/124893Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:27:28.595718Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Structural insights in mammalian sialyltransferases and fucosyltransferases
We have come a long way, but it is still a long way down
title Structural insights in mammalian sialyltransferases and fucosyltransferases
spellingShingle Structural insights in mammalian sialyltransferases and fucosyltransferases
Grewal, Ravneet Kaur
Drug design
Fucosyltransferase
Glyocosyltransferases in cancer
Sialyltransferase
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
SDG 3 - Good Health and Well-being
title_short Structural insights in mammalian sialyltransferases and fucosyltransferases
title_full Structural insights in mammalian sialyltransferases and fucosyltransferases
title_fullStr Structural insights in mammalian sialyltransferases and fucosyltransferases
title_full_unstemmed Structural insights in mammalian sialyltransferases and fucosyltransferases
title_sort Structural insights in mammalian sialyltransferases and fucosyltransferases
author Grewal, Ravneet Kaur
author_facet Grewal, Ravneet Kaur
Shaikh, Abdul Rajjak
Gorle, Suresh
Kaur, Manjeet
Videira, Paula Alexendra
Cavallo, Luigi
Chawla, Mohit
author_role author
author2 Shaikh, Abdul Rajjak
Gorle, Suresh
Kaur, Manjeet
Videira, Paula Alexendra
Cavallo, Luigi
Chawla, Mohit
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv DCV - Departamento de Ciências da Vida
UCIBIO - Applied Molecular Biosciences Unit
RUN
dc.contributor.author.fl_str_mv Grewal, Ravneet Kaur
Shaikh, Abdul Rajjak
Gorle, Suresh
Kaur, Manjeet
Videira, Paula Alexendra
Cavallo, Luigi
Chawla, Mohit
dc.subject.por.fl_str_mv Drug design
Fucosyltransferase
Glyocosyltransferases in cancer
Sialyltransferase
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
SDG 3 - Good Health and Well-being
topic Drug design
Fucosyltransferase
Glyocosyltransferases in cancer
Sialyltransferase
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
SDG 3 - Good Health and Well-being
description Funding Information: The APC was funded by King Abdullah University of Science and Technology. M.C.: L.C. and A.R.S. acknowledge the King Abdullah University of Science and Technology (KAUST) for support. We thank Romina Oliva, University of Parthenope (Naples), for helpful comments. Thanks to the STEMskills Research and Education Lab team members for support.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-21T02:07:51Z
2021-09-01
2021-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/124893
url http://hdl.handle.net/10362/124893
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1420-3049
PURE: 33717185
https://doi.org/10.3390/molecules26175203
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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