Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration

Bibliographic Details
Main Author: Gonçalves, Joana
Publication Date: 2020
Other Authors: Alves, Gilberto, Carona, Andreia, Bicker, Joana, Vitorino, Carla, Falcão, Amílcar, Fortuna, Ana
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/10316/90884
https://doi.org/10.1007/s11095-020-02786-z
Summary: Zonisamide clinical indications are expanding beyond the classic treatment of epileptic seizures to Parkinson's disease and other neurodegenerative diseases. However, the systemic safety profile of zonisamide may compromise its use as a first-line drug in any clinical condition. Since zonisamide is marketed as oral formulations, the present study aimed at exploring the potential of the intranasal route to centrally administer zonisamide, evaluating the systemic bioavailability of zonisamide and comparing its brain, lung and kidney pharmacokinetics after intranasal, oral and intravenous administrations.
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spelling Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal AdministrationZonisamideEpilepsyIntranasalMiceNose-to-brainPharmacokineticsZonisamide clinical indications are expanding beyond the classic treatment of epileptic seizures to Parkinson's disease and other neurodegenerative diseases. However, the systemic safety profile of zonisamide may compromise its use as a first-line drug in any clinical condition. Since zonisamide is marketed as oral formulations, the present study aimed at exploring the potential of the intranasal route to centrally administer zonisamide, evaluating the systemic bioavailability of zonisamide and comparing its brain, lung and kidney pharmacokinetics after intranasal, oral and intravenous administrations.Springer Nature2020-03-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://hdl.handle.net/10316/90884https://hdl.handle.net/10316/90884https://doi.org/10.1007/s11095-020-02786-zeng0724-87411573-904Xhttps://link.springer.com/content/pdf/10.1007/s11095-020-02786-z.pdfGonçalves, JoanaAlves, GilbertoCarona, AndreiaBicker, JoanaVitorino, CarlaFalcão, AmílcarFortuna, Anainfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2022-08-24T10:53:46Zoai:estudogeral.uc.pt:10316/90884Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T05:38:50.771549Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration
title Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration
spellingShingle Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration
Gonçalves, Joana
Zonisamide
Epilepsy
Intranasal
Mice
Nose-to-brain
Pharmacokinetics
title_short Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration
title_full Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration
title_fullStr Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration
title_full_unstemmed Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration
title_sort Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration
author Gonçalves, Joana
author_facet Gonçalves, Joana
Alves, Gilberto
Carona, Andreia
Bicker, Joana
Vitorino, Carla
Falcão, Amílcar
Fortuna, Ana
author_role author
author2 Alves, Gilberto
Carona, Andreia
Bicker, Joana
Vitorino, Carla
Falcão, Amílcar
Fortuna, Ana
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gonçalves, Joana
Alves, Gilberto
Carona, Andreia
Bicker, Joana
Vitorino, Carla
Falcão, Amílcar
Fortuna, Ana
dc.subject.por.fl_str_mv Zonisamide
Epilepsy
Intranasal
Mice
Nose-to-brain
Pharmacokinetics
topic Zonisamide
Epilepsy
Intranasal
Mice
Nose-to-brain
Pharmacokinetics
description Zonisamide clinical indications are expanding beyond the classic treatment of epileptic seizures to Parkinson's disease and other neurodegenerative diseases. However, the systemic safety profile of zonisamide may compromise its use as a first-line drug in any clinical condition. Since zonisamide is marketed as oral formulations, the present study aimed at exploring the potential of the intranasal route to centrally administer zonisamide, evaluating the systemic bioavailability of zonisamide and comparing its brain, lung and kidney pharmacokinetics after intranasal, oral and intravenous administrations.
publishDate 2020
dc.date.none.fl_str_mv 2020-03-25
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10316/90884
https://hdl.handle.net/10316/90884
https://doi.org/10.1007/s11095-020-02786-z
url https://hdl.handle.net/10316/90884
https://doi.org/10.1007/s11095-020-02786-z
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0724-8741
1573-904X
https://link.springer.com/content/pdf/10.1007/s11095-020-02786-z.pdf
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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