Alternative Serum Biomarkers of Bacteraemia for Intensive Care Unit Patients

Bibliographic Details
Main Author: Araújo, Rúben
Publication Date: 2023
Other Authors: Ramalhete, Luís, Fonseca, Tiago, Von Rekowski, Cristiana, Bento, Luís, Calado, Cecília R.C.
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/158230
Summary: Funding Information: This work was supported by the project grant DSAIPA/DS/0117/2020 supported by Fundação para a Ciência e a Tecnologia, Portugal and by the project grant NeproMD/ISEL/2020 financed by Instituto Politécnico de Lisboa. Publisher Copyright: © 2023 IEEE.
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spelling Alternative Serum Biomarkers of Bacteraemia for Intensive Care Unit PatientsBiomarkersFTIR spectroscopyInfectionIntensive Care UnitBiomedical EngineeringRadiology Nuclear Medicine and imagingInstrumentationFunding Information: This work was supported by the project grant DSAIPA/DS/0117/2020 supported by Fundação para a Ciência e a Tecnologia, Portugal and by the project grant NeproMD/ISEL/2020 financed by Instituto Politécnico de Lisboa. Publisher Copyright: © 2023 IEEE.The diagnosis of infections in hospital or clinical settings usually involves a series of time-consuming steps, including biological sample collection, culture growth of the organism isolation and subsequent characterization. For this, there are diverse infection biomarkers based on blood analysis, however, these are of limited use in patients presenting confound processes as inflammatory process as occurring at intensive care units. In this preliminary study, the application of serum analysis by FTIR spectroscopy, to predict bacteraemia in 102 critically ill patients in an ICU was evaluated. It was analysed the effect of spectra pre-processing methods and spectral sub-regions on t-distributed stochastic neighbour embedding. By optimizing Support Vector Machine (SVM) models, based on normalised second derivative spectra of a smaller subregion, it was possible to achieve a good bacteraemia predictive model with a sensitivity and specificity of 76%. Since FTIR spectra of serum is acquired in a simple, economic and rapid mode, the technique presents the potential to be a cost-effective methodology of bacteraemia identification, with special relevance in critically ill patients, where a rapid infection diagnostic will allow to avoid the unnecessary use of antibiotics, which ultimately will ease the load on already fragile patients' metabolism.Institute of Electrical and Electronics Engineers (IEEE)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSiNOVA4Health - pólo NMSRUNAraújo, RúbenRamalhete, LuísFonseca, TiagoVon Rekowski, CristianaBento, LuísCalado, Cecília R.C.2023-09-25T22:12:46Z20232023-01-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersion4application/pdfhttp://hdl.handle.net/10362/158230eng9798350322576PURE: 70475089https://doi.org/10.1109/ENBENG58165.2023.10175340info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-10-21T01:36:51Zoai:run.unl.pt:10362/158230Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:45:09.606627Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Alternative Serum Biomarkers of Bacteraemia for Intensive Care Unit Patients
title Alternative Serum Biomarkers of Bacteraemia for Intensive Care Unit Patients
spellingShingle Alternative Serum Biomarkers of Bacteraemia for Intensive Care Unit Patients
Araújo, Rúben
Biomarkers
FTIR spectroscopy
Infection
Intensive Care Unit
Biomedical Engineering
Radiology Nuclear Medicine and imaging
Instrumentation
title_short Alternative Serum Biomarkers of Bacteraemia for Intensive Care Unit Patients
title_full Alternative Serum Biomarkers of Bacteraemia for Intensive Care Unit Patients
title_fullStr Alternative Serum Biomarkers of Bacteraemia for Intensive Care Unit Patients
title_full_unstemmed Alternative Serum Biomarkers of Bacteraemia for Intensive Care Unit Patients
title_sort Alternative Serum Biomarkers of Bacteraemia for Intensive Care Unit Patients
author Araújo, Rúben
author_facet Araújo, Rúben
Ramalhete, Luís
Fonseca, Tiago
Von Rekowski, Cristiana
Bento, Luís
Calado, Cecília R.C.
author_role author
author2 Ramalhete, Luís
Fonseca, Tiago
Von Rekowski, Cristiana
Bento, Luís
Calado, Cecília R.C.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
iNOVA4Health - pólo NMS
RUN
dc.contributor.author.fl_str_mv Araújo, Rúben
Ramalhete, Luís
Fonseca, Tiago
Von Rekowski, Cristiana
Bento, Luís
Calado, Cecília R.C.
dc.subject.por.fl_str_mv Biomarkers
FTIR spectroscopy
Infection
Intensive Care Unit
Biomedical Engineering
Radiology Nuclear Medicine and imaging
Instrumentation
topic Biomarkers
FTIR spectroscopy
Infection
Intensive Care Unit
Biomedical Engineering
Radiology Nuclear Medicine and imaging
Instrumentation
description Funding Information: This work was supported by the project grant DSAIPA/DS/0117/2020 supported by Fundação para a Ciência e a Tecnologia, Portugal and by the project grant NeproMD/ISEL/2020 financed by Instituto Politécnico de Lisboa. Publisher Copyright: © 2023 IEEE.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-25T22:12:46Z
2023
2023-01-01T00:00:00Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158230
url http://hdl.handle.net/10362/158230
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 9798350322576
PURE: 70475089
https://doi.org/10.1109/ENBENG58165.2023.10175340
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 4
application/pdf
dc.publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers (IEEE)
publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers (IEEE)
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596936663334912

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