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Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells

Bibliographic Details
Main Author: Nunes, Raquel J.
Publication Date: 2013
Other Authors: Oliveira, Paula de, Lages, Ana, Becker, Jörg D., Marcelino, Paulo, Barroso, Eduardo, Perdigoto, Rui, Kelly, Jeffery W., Quintas, Alexandre, Santos, Susana C. R.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.26/6945
Summary: "Background: The biological effects of transthyretin proteins on vasculature remain unknown. Results: V30M transthyretin tetramer modulates endothelial global gene expression, down-regulating pro-angiogenic genes, inducing apoptosis and inhibiting migration. Conclusion: Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells. Significance: This work has critical implications in the prevention of early hepatic artery thrombosis in familial amyloidotic polyneuropathy patients after liver transplantation."
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network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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spelling Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial CellsAngiogenesisEndothelial CellFamilial Amyloidotic PolyneuropathyGene ExpressionMicroarrayTransthyretinVascular Biology"Background: The biological effects of transthyretin proteins on vasculature remain unknown. Results: V30M transthyretin tetramer modulates endothelial global gene expression, down-regulating pro-angiogenic genes, inducing apoptosis and inhibiting migration. Conclusion: Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells. Significance: This work has critical implications in the prevention of early hepatic artery thrombosis in familial amyloidotic polyneuropathy patients after liver transplantation."ASBMBRepositório ComumNunes, Raquel J.Oliveira, Paula deLages, AnaBecker, Jörg D.Marcelino, PauloBarroso, EduardoPerdigoto, RuiKelly, Jeffery W.Quintas, AlexandreSantos, Susana C. R.2014-11-06T14:20:47Z2013-11-012013-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/6945eng0021-9258e-1083-351X10.1074/jbc.M113.469858info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-01T16:52:53Zoai:comum.rcaap.pt:10400.26/6945Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T04:45:45.098456Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
title Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
spellingShingle Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
Nunes, Raquel J.
Angiogenesis
Endothelial Cell
Familial Amyloidotic Polyneuropathy
Gene Expression
Microarray
Transthyretin
Vascular Biology
title_short Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
title_full Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
title_fullStr Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
title_full_unstemmed Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
title_sort Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
author Nunes, Raquel J.
author_facet Nunes, Raquel J.
Oliveira, Paula de
Lages, Ana
Becker, Jörg D.
Marcelino, Paulo
Barroso, Eduardo
Perdigoto, Rui
Kelly, Jeffery W.
Quintas, Alexandre
Santos, Susana C. R.
author_role author
author2 Oliveira, Paula de
Lages, Ana
Becker, Jörg D.
Marcelino, Paulo
Barroso, Eduardo
Perdigoto, Rui
Kelly, Jeffery W.
Quintas, Alexandre
Santos, Susana C. R.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Nunes, Raquel J.
Oliveira, Paula de
Lages, Ana
Becker, Jörg D.
Marcelino, Paulo
Barroso, Eduardo
Perdigoto, Rui
Kelly, Jeffery W.
Quintas, Alexandre
Santos, Susana C. R.
dc.subject.por.fl_str_mv Angiogenesis
Endothelial Cell
Familial Amyloidotic Polyneuropathy
Gene Expression
Microarray
Transthyretin
Vascular Biology
topic Angiogenesis
Endothelial Cell
Familial Amyloidotic Polyneuropathy
Gene Expression
Microarray
Transthyretin
Vascular Biology
description "Background: The biological effects of transthyretin proteins on vasculature remain unknown. Results: V30M transthyretin tetramer modulates endothelial global gene expression, down-regulating pro-angiogenic genes, inducing apoptosis and inhibiting migration. Conclusion: Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells. Significance: This work has critical implications in the prevention of early hepatic artery thrombosis in familial amyloidotic polyneuropathy patients after liver transplantation."
publishDate 2013
dc.date.none.fl_str_mv 2013-11-01
2013-11-01T00:00:00Z
2014-11-06T14:20:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/6945
url http://hdl.handle.net/10400.26/6945
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0021-9258
e-1083-351X
10.1074/jbc.M113.469858
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ASBMB
publisher.none.fl_str_mv ASBMB
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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