Algae-Based Supplements Claiming Weight Loss Properties

Bibliographic Details
Main Author: Fernandes, Fátima
Publication Date: 2024
Other Authors: Martins, Raquel, Barbosa, Mariana, Valentão, Patrícia
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/179055
Summary: Funding Information: This work received financial support from Portuguese national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDP/5006/2020. F. Fernandes thanks FCT for funding through program DL 57/2016—Norma transitória (Ref. DL57/2016/CP1346/CT0018). Publisher Copyright: © 2024 by the authors.
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spelling Algae-Based Supplements Claiming Weight Loss PropertiesAuthenticity Control and Scientific-Based Evidence on Their Effectivenessalgaeanti-obesityantioxidantfood supplementsFucus vesiculosusquality controlspirulinaPharmaceutical ScienceDrug DiscoveryPharmacology, Toxicology and Pharmaceutics (miscellaneous)SDG 3 - Good Health and Well-beingFunding Information: This work received financial support from Portuguese national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDP/5006/2020. F. Fernandes thanks FCT for funding through program DL 57/2016—Norma transitória (Ref. DL57/2016/CP1346/CT0018). Publisher Copyright: © 2024 by the authors.The worldwide prevalence of obesity impacts more than 600 million adults. Successfully managing weight is effective in reducing the risk of chronic diseases, but sustaining long-term weight loss remains a challenge. Although there are supplements based on algae that claim to aid in weight loss, there is a notable scarcity of scientific evidence supporting their effectiveness, and their regular consumption safety remains inadequately addressed. In this work, commercially available Arthrospira (Spirulina) platensis Gomont and/or Fucus vesiculosus L. supplements showed moderate capacity to inhibit the activity of carbohydrate-metabolizing enzymes, and to scavenge biologically relevant reactive species. IC25 values varying between 4.54 ± 0.81 and 66.73 ± 5.91 µg of dry extract/mL and between 53.74 ± 8.42 and 1737.96 ± 98.26 µg of dry extract/mL were obtained for α-glucosidase and aldose reductase, respectively. A weaker effect towards α-amylase activity was observed, with a maximum activity of the extracts not going beyond 33%, at the highest concentrations tested. Spirulina extracts showed generally better effects than those from F. vesiculosus. Similar results were observed concerning the antiradical capacity. In a general way, the extracts were able to intercept the in vitro-generated reactive species nitric oxide (•NO) and superoxide anion (O2•−) radicals, with better results for O2•−scavenging with the spirulina samples (IC25 values of 67.16 and 122.84 µg of dry extract/mL). Chemically, similar pigment profiles were observed between spirulina supplements and the authenticated counterpart. However, fucoxanthin, the chemotaxonomic marker of brown seaweeds, was not found in F. vesiculosus samples, pointing to the occurrence of a degradation phenomenon before, during, or after raw material processing. Our findings can contribute to providing data to allow regulatory entities (e.g., EFSA and FDA) to better rule these products in a way that can benefit society.Faculdade de Ciências e Tecnologia (FCT)RUNFernandes, FátimaMartins, RaquelBarbosa, MarianaValentão, Patrícia2025-02-14T21:18:10Z2024-03-052024-03-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/179055eng1660-3397PURE: 99744563https://doi.org/10.3390/md22030123info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-24T01:45:58Zoai:run.unl.pt:10362/179055Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T20:39:42.500751Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Algae-Based Supplements Claiming Weight Loss Properties
Authenticity Control and Scientific-Based Evidence on Their Effectiveness
title Algae-Based Supplements Claiming Weight Loss Properties
spellingShingle Algae-Based Supplements Claiming Weight Loss Properties
Fernandes, Fátima
algae
anti-obesity
antioxidant
food supplements
Fucus vesiculosus
quality control
spirulina
Pharmaceutical Science
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
SDG 3 - Good Health and Well-being
title_short Algae-Based Supplements Claiming Weight Loss Properties
title_full Algae-Based Supplements Claiming Weight Loss Properties
title_fullStr Algae-Based Supplements Claiming Weight Loss Properties
title_full_unstemmed Algae-Based Supplements Claiming Weight Loss Properties
title_sort Algae-Based Supplements Claiming Weight Loss Properties
author Fernandes, Fátima
author_facet Fernandes, Fátima
Martins, Raquel
Barbosa, Mariana
Valentão, Patrícia
author_role author
author2 Martins, Raquel
Barbosa, Mariana
Valentão, Patrícia
author2_role author
author
author
dc.contributor.none.fl_str_mv Faculdade de Ciências e Tecnologia (FCT)
RUN
dc.contributor.author.fl_str_mv Fernandes, Fátima
Martins, Raquel
Barbosa, Mariana
Valentão, Patrícia
dc.subject.por.fl_str_mv algae
anti-obesity
antioxidant
food supplements
Fucus vesiculosus
quality control
spirulina
Pharmaceutical Science
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
SDG 3 - Good Health and Well-being
topic algae
anti-obesity
antioxidant
food supplements
Fucus vesiculosus
quality control
spirulina
Pharmaceutical Science
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
SDG 3 - Good Health and Well-being
description Funding Information: This work received financial support from Portuguese national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDP/5006/2020. F. Fernandes thanks FCT for funding through program DL 57/2016—Norma transitória (Ref. DL57/2016/CP1346/CT0018). Publisher Copyright: © 2024 by the authors.
publishDate 2024
dc.date.none.fl_str_mv 2024-03-05
2024-03-05T00:00:00Z
2025-02-14T21:18:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/179055
url http://hdl.handle.net/10362/179055
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1660-3397
PURE: 99744563
https://doi.org/10.3390/md22030123
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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