Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Biomarkers and Frailty
| Main Author: | |
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| Publication Date: | 2015 |
| Other Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/152378 |
Summary: | Funding: This meeting was founded by the European Society for Clinical and Economics Aspect of Osteoporosis and Osteoarthritis, a not for profit organization from Belgium. |
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Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Biomarkers and FrailtyGeriatrics and GerontologyPharmacology (medical)Funding: This meeting was founded by the European Society for Clinical and Economics Aspect of Osteoporosis and Osteoarthritis, a not for profit organization from Belgium.Osteoarthritis (OA), a disease affecting different patient phenotypes, appears as an optimal candidate for personalized healthcare. The aim of the discussions of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) working group was to explore the value of markers of different sources in defining different phenotypes of patients with OA. The ESCEO organized a series of meetings to explore the possibility of identifying patients who would most benefit from treatment for OA, on the basis of recent data and expert opinion. In the first meeting, patient phenotypes were identified according to the number of affected joints, biomechanical factors, and the presence of lesions in the subchondral bone. In the second meeting, summarized in the present article, the working group explored other markers involved in OA. Profiles of patients may be defined according to their level of pain, functional limitation, and presence of coexistent chronic conditions including frailty status. A considerable amount of data suggests that magnetic resonance imaging may also assist in delineating different phenotypes of patients with OA. Among multiple biochemical biomarkers identified, none is sufficiently validated and recognized to identify patients who should be treated. Considerable efforts are also being made to identify genetic and epigenetic factors involved in OA, but results are still limited. The many potential biomarkers that could be used as potential stratifiers are promising, but more research is needed to characterize and qualify the existing biomarkers and to identify new candidates.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNArden, NigelRichette, PascalCooper, CyrusBruyère, OlivierAbadie, EricBranco, JaimeBrandi, Maria LuisaBerenbaum, FrancisClerc, CécileDennison, ElaineDevogelaer, Jean PierreHochberg, MarcD’Hooghe, PieterHerrero-Beaumont, GabrielKanis, John A.Laslop, AndreaLeblanc, VéroniqueMaggi, StefaniaMautone, GiuseppePelletier, Jean PierrePetit-Dop, FlorenceReiter-Niesert, SusanneRizzoli, RenéRovati, LucioTajana Messi, EleonoraTsouderos, YannisMartel-Pelletier, JohanneReginster, Jean Yves2023-05-03T22:07:44Z2015-07-292015-07-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/152378eng1170-229XPURE: 3201790https://doi.org/10.1007/s40266-015-0276-7info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:11:12Zoai:run.unl.pt:10362/152378Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:41:28.298669Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Biomarkers and Frailty |
| title |
Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Biomarkers and Frailty |
| spellingShingle |
Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Biomarkers and Frailty Arden, Nigel Geriatrics and Gerontology Pharmacology (medical) |
| title_short |
Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Biomarkers and Frailty |
| title_full |
Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Biomarkers and Frailty |
| title_fullStr |
Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Biomarkers and Frailty |
| title_full_unstemmed |
Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Biomarkers and Frailty |
| title_sort |
Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Biomarkers and Frailty |
| author |
Arden, Nigel |
| author_facet |
Arden, Nigel Richette, Pascal Cooper, Cyrus Bruyère, Olivier Abadie, Eric Branco, Jaime Brandi, Maria Luisa Berenbaum, Francis Clerc, Cécile Dennison, Elaine Devogelaer, Jean Pierre Hochberg, Marc D’Hooghe, Pieter Herrero-Beaumont, Gabriel Kanis, John A. Laslop, Andrea Leblanc, Véronique Maggi, Stefania Mautone, Giuseppe Pelletier, Jean Pierre Petit-Dop, Florence Reiter-Niesert, Susanne Rizzoli, René Rovati, Lucio Tajana Messi, Eleonora Tsouderos, Yannis Martel-Pelletier, Johanne Reginster, Jean Yves |
| author_role |
author |
| author2 |
Richette, Pascal Cooper, Cyrus Bruyère, Olivier Abadie, Eric Branco, Jaime Brandi, Maria Luisa Berenbaum, Francis Clerc, Cécile Dennison, Elaine Devogelaer, Jean Pierre Hochberg, Marc D’Hooghe, Pieter Herrero-Beaumont, Gabriel Kanis, John A. Laslop, Andrea Leblanc, Véronique Maggi, Stefania Mautone, Giuseppe Pelletier, Jean Pierre Petit-Dop, Florence Reiter-Niesert, Susanne Rizzoli, René Rovati, Lucio Tajana Messi, Eleonora Tsouderos, Yannis Martel-Pelletier, Johanne Reginster, Jean Yves |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
| dc.contributor.author.fl_str_mv |
Arden, Nigel Richette, Pascal Cooper, Cyrus Bruyère, Olivier Abadie, Eric Branco, Jaime Brandi, Maria Luisa Berenbaum, Francis Clerc, Cécile Dennison, Elaine Devogelaer, Jean Pierre Hochberg, Marc D’Hooghe, Pieter Herrero-Beaumont, Gabriel Kanis, John A. Laslop, Andrea Leblanc, Véronique Maggi, Stefania Mautone, Giuseppe Pelletier, Jean Pierre Petit-Dop, Florence Reiter-Niesert, Susanne Rizzoli, René Rovati, Lucio Tajana Messi, Eleonora Tsouderos, Yannis Martel-Pelletier, Johanne Reginster, Jean Yves |
| dc.subject.por.fl_str_mv |
Geriatrics and Gerontology Pharmacology (medical) |
| topic |
Geriatrics and Gerontology Pharmacology (medical) |
| description |
Funding: This meeting was founded by the European Society for Clinical and Economics Aspect of Osteoporosis and Osteoarthritis, a not for profit organization from Belgium. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-07-29 2015-07-29T00:00:00Z 2023-05-03T22:07:44Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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publishedVersion |
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http://hdl.handle.net/10362/152378 |
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http://hdl.handle.net/10362/152378 |
| dc.language.iso.fl_str_mv |
eng |
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eng |
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1170-229X PURE: 3201790 https://doi.org/10.1007/s40266-015-0276-7 |
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