Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of Osteoarthritis

Bibliographic Details
Main Author: Bruyère, Olivier
Publication Date: 2015
Other Authors: Cooper, Cyrus, Arden, Nigel, Branco, Jaime, Brandi, Maria Luisa, Herrero-Beaumont, Gabriel, Berenbaum, Francis, Dennison, Elaine, Devogelaer, Jean Pierre, Hochberg, Marc, Kanis, John, Laslop, Andrea, McAlindon, Tim, Reiter, Susanne, Richette, Pascal, Rizzoli, René, Reginster, Jean Yves
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/145223
Summary: Publisher Copyright: © 2015, The Author(s).
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spelling Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of OsteoarthritisGeriatrics and GerontologyPharmacology (medical)SDG 3 - Good Health and Well-beingPublisher Copyright: © 2015, The Author(s).Osteoarthritis is a syndrome affecting a variety of patient profiles. A European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis and the European Union Geriatric Medicine Society working meeting explored the possibility of identifying different patient profiles in osteoarthritis. The risk factors for the development of osteoarthritis include systemic factors (e.g., age, sex, obesity, genetics, race, and bone density) and local biomechanical factors (e.g., obesity, sport, joint injury, and muscle weakness); most also predict disease progression, particularly joint injury, malalignment, and synovitis/effusion. The characterization of patient profiles should help to better orientate research, facilitate trial design, and define which patients are the most likely to benefit from treatment. There are a number of profile candidates. Generalized, polyarticular osteoarthritis and local, monoarticular osteoarthritis appear to be two different profiles; the former is a feature of osteoarthritis co-morbid with inflammation or the metabolic syndrome, while the latter is more typical of post-trauma osteoarthritis, especially in cases with severe malalignment. Other biomechanical factors may also define profiles, such as joint malalignment, loss of meniscal function, and ligament injury. Early- and late-stage osteoarthritis appear as separate profiles, notably in terms of treatment response. Finally, there is evidence that there are two separate profiles related to lesions in the subchondral bone, which may determine benefit from bone-active treatments. Decisions on appropriate therapy should be made considering clinical presentation, underlying pathophysiology, and stage of disease. Identification of patient profiles may lead to more personalized healthcare, with more targeted treatment for osteoarthritis.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNBruyère, OlivierCooper, CyrusArden, NigelBranco, JaimeBrandi, Maria LuisaHerrero-Beaumont, GabrielBerenbaum, FrancisDennison, ElaineDevogelaer, Jean PierreHochberg, MarcKanis, JohnLaslop, AndreaMcAlindon, TimReiter, SusanneRichette, PascalRizzoli, RenéReginster, Jean Yves2022-11-03T22:14:13Z2015-03-202015-03-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://hdl.handle.net/10362/145223eng1170-229XPURE: 47545626https://doi.org/10.1007/s40266-015-0243-3info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:06:24Zoai:run.unl.pt:10362/145223Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:37:00.854848Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of Osteoarthritis
title Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of Osteoarthritis
spellingShingle Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of Osteoarthritis
Bruyère, Olivier
Geriatrics and Gerontology
Pharmacology (medical)
SDG 3 - Good Health and Well-being
title_short Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of Osteoarthritis
title_full Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of Osteoarthritis
title_fullStr Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of Osteoarthritis
title_full_unstemmed Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of Osteoarthritis
title_sort Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of Osteoarthritis
author Bruyère, Olivier
author_facet Bruyère, Olivier
Cooper, Cyrus
Arden, Nigel
Branco, Jaime
Brandi, Maria Luisa
Herrero-Beaumont, Gabriel
Berenbaum, Francis
Dennison, Elaine
Devogelaer, Jean Pierre
Hochberg, Marc
Kanis, John
Laslop, Andrea
McAlindon, Tim
Reiter, Susanne
Richette, Pascal
Rizzoli, René
Reginster, Jean Yves
author_role author
author2 Cooper, Cyrus
Arden, Nigel
Branco, Jaime
Brandi, Maria Luisa
Herrero-Beaumont, Gabriel
Berenbaum, Francis
Dennison, Elaine
Devogelaer, Jean Pierre
Hochberg, Marc
Kanis, John
Laslop, Andrea
McAlindon, Tim
Reiter, Susanne
Richette, Pascal
Rizzoli, René
Reginster, Jean Yves
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Bruyère, Olivier
Cooper, Cyrus
Arden, Nigel
Branco, Jaime
Brandi, Maria Luisa
Herrero-Beaumont, Gabriel
Berenbaum, Francis
Dennison, Elaine
Devogelaer, Jean Pierre
Hochberg, Marc
Kanis, John
Laslop, Andrea
McAlindon, Tim
Reiter, Susanne
Richette, Pascal
Rizzoli, René
Reginster, Jean Yves
dc.subject.por.fl_str_mv Geriatrics and Gerontology
Pharmacology (medical)
SDG 3 - Good Health and Well-being
topic Geriatrics and Gerontology
Pharmacology (medical)
SDG 3 - Good Health and Well-being
description Publisher Copyright: © 2015, The Author(s).
publishDate 2015
dc.date.none.fl_str_mv 2015-03-20
2015-03-20T00:00:00Z
2022-11-03T22:14:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/145223
url http://hdl.handle.net/10362/145223
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1170-229X
PURE: 47545626
https://doi.org/10.1007/s40266-015-0243-3
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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instacron_str RCAAP
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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