Electrospun Polycaprolactone Membranes Expanded with Chitosan Granules for Cell Infiltration

Bibliographic Details
Main Author: Vieira, Tânia
Publication Date: 2024
Other Authors: Rebelo, Ana Margarida, Borges, João Paulo, Henriques, Célia, Silva, Jorge Carvalho
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/166303
Summary: Publisher Copyright: © 2024 by the authors.
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spelling Electrospun Polycaprolactone Membranes Expanded with Chitosan Granules for Cell Infiltrationcell infiltrationchitosanelectrospinningpolycaprolactoneporesChemistry(all)Polymers and PlasticsPublisher Copyright: © 2024 by the authors.The small pore size of electrospun membranes prevents their use as three-dimensional scaffolds. In this work, we produced polycaprolactone (PCL) electrospun fibrous membranes with expanded pores by incorporating chitosan (CS) granules into the PCL solution. Scanning electron microscopy images confirmed the presence of the CS granules embedded in the PCL fibers, creating an open structure. Tensile testing results showed that the addition of CS decreased both Young’s modulus and the yield stress, but co-electrospun membranes (PCL fibers blended with CS-containing PCL fibers) exhibited higher values compared to single electrospun membranes (CS-containing PCL fibers). Human fibroblasts adhered to and proliferated on all scaffolds. Nuclear staining revealed that cells populated the entire scaffold when CS granules were present, while in PCL membranes, cells were mostly limited to the surface due to the small pore size. Overall, our findings demonstrate that electrospun membranes containing CS granules have sufficiently large pores to facilitate fibroblast infiltration without compromising the mechanical stability of the structure.DF – Departamento de FísicaCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisRUNVieira, TâniaRebelo, Ana MargaridaBorges, João PauloHenriques, CéliaSilva, Jorge Carvalho2024-04-17T01:24:31Z2024-02-152024-02-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://hdl.handle.net/10362/166303eng2073-4360PURE: 87107198https://doi.org/10.3390/polym16040527info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:20:31Zoai:run.unl.pt:10362/166303Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:51:10.697784Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Electrospun Polycaprolactone Membranes Expanded with Chitosan Granules for Cell Infiltration
title Electrospun Polycaprolactone Membranes Expanded with Chitosan Granules for Cell Infiltration
spellingShingle Electrospun Polycaprolactone Membranes Expanded with Chitosan Granules for Cell Infiltration
Vieira, Tânia
cell infiltration
chitosan
electrospinning
polycaprolactone
pores
Chemistry(all)
Polymers and Plastics
title_short Electrospun Polycaprolactone Membranes Expanded with Chitosan Granules for Cell Infiltration
title_full Electrospun Polycaprolactone Membranes Expanded with Chitosan Granules for Cell Infiltration
title_fullStr Electrospun Polycaprolactone Membranes Expanded with Chitosan Granules for Cell Infiltration
title_full_unstemmed Electrospun Polycaprolactone Membranes Expanded with Chitosan Granules for Cell Infiltration
title_sort Electrospun Polycaprolactone Membranes Expanded with Chitosan Granules for Cell Infiltration
author Vieira, Tânia
author_facet Vieira, Tânia
Rebelo, Ana Margarida
Borges, João Paulo
Henriques, Célia
Silva, Jorge Carvalho
author_role author
author2 Rebelo, Ana Margarida
Borges, João Paulo
Henriques, Célia
Silva, Jorge Carvalho
author2_role author
author
author
author
dc.contributor.none.fl_str_mv DF – Departamento de Física
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
DCM - Departamento de Ciência dos Materiais
RUN
dc.contributor.author.fl_str_mv Vieira, Tânia
Rebelo, Ana Margarida
Borges, João Paulo
Henriques, Célia
Silva, Jorge Carvalho
dc.subject.por.fl_str_mv cell infiltration
chitosan
electrospinning
polycaprolactone
pores
Chemistry(all)
Polymers and Plastics
topic cell infiltration
chitosan
electrospinning
polycaprolactone
pores
Chemistry(all)
Polymers and Plastics
description Publisher Copyright: © 2024 by the authors.
publishDate 2024
dc.date.none.fl_str_mv 2024-04-17T01:24:31Z
2024-02-15
2024-02-15T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/166303
url http://hdl.handle.net/10362/166303
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2073-4360
PURE: 87107198
https://doi.org/10.3390/polym16040527
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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