Cellulose Acetate and Polycaprolactone Fibre Coatings on Medical-Grade Metal Substrates for Controlled Drug Release

Bibliographic Details
Main Author: Cidade do Carmo, Catarina
Publication Date: 2024
Other Authors: Brito, Miguel, Oliveira, J. P., Marques, Ana, Ferreira, Isabel, Baptista, Ana Catarina
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/174212
Summary: Publisher Copyright: © 2024 by the authors.
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spelling Cellulose Acetate and Polycaprolactone Fibre Coatings on Medical-Grade Metal Substrates for Controlled Drug Releaseblow spinningcellulose acetatedrug releaseelectrospinningibuprofenpolycaprolactoneChemistry(all)Polymers and PlasticsPublisher Copyright: © 2024 by the authors.This study explores a method that has the potential to be cost effective in inhibiting biofilm formation on metallic prostheses, thereby preventing rejection or the requirement for replacement. A cost-effective metal alloy used in biomedical implants was chosen as the substrate, and ibuprofen (Ibu), a well-known anti-inflammatory drug, was selected for drug release tests for its widespread availability and accessibility. Multilayer coatings consisting of cellulose acetate (CA), polycaprolactone (PCL), and chitosan (CHI), with or without ibuprofen (Ibu) content, were applied onto medical-grade stainless steel (SS-316 type) through electrospinning, electrospray, or blow spinning. The adhesion of the CA, PCL, and layered CA/PCL membranes, with thicknesses ranging from 20 to 100 μm, to SS substrates varied between 0.15 N and 0.22 N without CHI, which increased to 0.21 and 0.74 N, respectively, when a CHI interlayer was introduced by electrospraying between the SS and the coatings. Although drug release in a simulated body fluid (SBF) medium is predominantly governed by diffusion-driven mechanisms in all single- and multilayer coatings, a delayed release was noted in CA coatings containing Ibu when overlaid with a PCL coating produced by blow spinning. This suggests avenues for further investigations into combinations of multilayer coatings, both with and without drug-imbued layers.DCM - Departamento de Ciência dos MateriaisCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)RUNCidade do Carmo, CatarinaBrito, MiguelOliveira, J. P.Marques, AnaFerreira, IsabelBaptista, Ana Catarina2024-10-29T00:37:42Z2024-07-132024-07-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://hdl.handle.net/10362/174212engCidade do Carmo, C., Brito, M., Oliveira, J. P., Marques, A., Ferreira, I., & Baptista, A. C. (2024). Cellulose Acetate and Polycaprolactone Fibre Coatings on Medical-Grade Metal Substrates for Controlled Drug Release. Polymers, 16(14), Article 2006. https://doi.org/10.3390/polym161420062073-4360PURE: 101021121https://doi.org/10.3390/polym16142006info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-01-20T01:37:00Zoai:run.unl.pt:10362/174212Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:12:36.332192Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Cellulose Acetate and Polycaprolactone Fibre Coatings on Medical-Grade Metal Substrates for Controlled Drug Release
title Cellulose Acetate and Polycaprolactone Fibre Coatings on Medical-Grade Metal Substrates for Controlled Drug Release
spellingShingle Cellulose Acetate and Polycaprolactone Fibre Coatings on Medical-Grade Metal Substrates for Controlled Drug Release
Cidade do Carmo, Catarina
blow spinning
cellulose acetate
drug release
electrospinning
ibuprofen
polycaprolactone
Chemistry(all)
Polymers and Plastics
title_short Cellulose Acetate and Polycaprolactone Fibre Coatings on Medical-Grade Metal Substrates for Controlled Drug Release
title_full Cellulose Acetate and Polycaprolactone Fibre Coatings on Medical-Grade Metal Substrates for Controlled Drug Release
title_fullStr Cellulose Acetate and Polycaprolactone Fibre Coatings on Medical-Grade Metal Substrates for Controlled Drug Release
title_full_unstemmed Cellulose Acetate and Polycaprolactone Fibre Coatings on Medical-Grade Metal Substrates for Controlled Drug Release
title_sort Cellulose Acetate and Polycaprolactone Fibre Coatings on Medical-Grade Metal Substrates for Controlled Drug Release
author Cidade do Carmo, Catarina
author_facet Cidade do Carmo, Catarina
Brito, Miguel
Oliveira, J. P.
Marques, Ana
Ferreira, Isabel
Baptista, Ana Catarina
author_role author
author2 Brito, Miguel
Oliveira, J. P.
Marques, Ana
Ferreira, Isabel
Baptista, Ana Catarina
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv DCM - Departamento de Ciência dos Materiais
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
RUN
dc.contributor.author.fl_str_mv Cidade do Carmo, Catarina
Brito, Miguel
Oliveira, J. P.
Marques, Ana
Ferreira, Isabel
Baptista, Ana Catarina
dc.subject.por.fl_str_mv blow spinning
cellulose acetate
drug release
electrospinning
ibuprofen
polycaprolactone
Chemistry(all)
Polymers and Plastics
topic blow spinning
cellulose acetate
drug release
electrospinning
ibuprofen
polycaprolactone
Chemistry(all)
Polymers and Plastics
description Publisher Copyright: © 2024 by the authors.
publishDate 2024
dc.date.none.fl_str_mv 2024-10-29T00:37:42Z
2024-07-13
2024-07-13T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/174212
url http://hdl.handle.net/10362/174212
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cidade do Carmo, C., Brito, M., Oliveira, J. P., Marques, A., Ferreira, I., & Baptista, A. C. (2024). Cellulose Acetate and Polycaprolactone Fibre Coatings on Medical-Grade Metal Substrates for Controlled Drug Release. Polymers, 16(14), Article 2006. https://doi.org/10.3390/polym16142006
2073-4360
PURE: 101021121
https://doi.org/10.3390/polym16142006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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