How to use biomarkers of infection or sepsis at the bedside
| Main Author: | |
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| Publication Date: | 2023 |
| Other Authors: | , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/147554 |
Summary: | Funding This work received an unrestricted grant from GSK Portugal and was supported by Sociedade Portuguesa de Ginecologia (SPG). |
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How to use biomarkers of infection or sepsis at the bedsideguide to cliniciansAntibiotic stewardshipBiomarkersDiagnosisIntensive care unitSepsisCritical Care and Intensive Care MedicineFunding This work received an unrestricted grant from GSK Portugal and was supported by Sociedade Portuguesa de Ginecologia (SPG).Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. In this context, biomarkers could be considered as indicators of either infection or dysregulated host response or response to treatment and/or aid clinicians to prognosticate patient risk. More than 250 biomarkers have been identified and evaluated over the last few decades, but no biomarker accurately differentiates between sepsis and sepsis-like syndrome. Published data support the use of biomarkers for pathogen identification, clinical diagnosis, and optimization of antibiotic treatment. In this narrative review, we highlight how clinicians could improve the use of pathogen-specific and of the most used host-response biomarkers, procalcitonin and C-reactive protein, to improve the clinical care of patients with sepsis. Biomarker kinetics are more useful than single values in predicting sepsis, when making the diagnosis and assessing the response to antibiotic therapy. Finally, integrated biomarker-guided algorithms may hold promise to improve both the diagnosis and prognosis of sepsis. Herein, we provide current data on the clinical utility of pathogen-specific and host-response biomarkers, offer guidance on how to optimize their use, and propose the needs for future research.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNPóvoa, PedroCoelho, LuísDal-Pizzol, FelipeFerrer, RicardHuttner, AngelaConway Morris, AndrewNobre, VandackRamirez, PaulaRouze, AnahitaSalluh, JorgeSinger, MervynSweeney, Daniel A.Torres, AntoniWaterer, GrantKalil, Andre C.2023-01-13T22:20:28Z2023-022023-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/147554eng0342-4642PURE: 50125976https://doi.org/10.1007/s00134-022-06956-yinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:08:09Zoai:run.unl.pt:10362/147554Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:38:37.765981Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
How to use biomarkers of infection or sepsis at the bedside guide to clinicians |
| title |
How to use biomarkers of infection or sepsis at the bedside |
| spellingShingle |
How to use biomarkers of infection or sepsis at the bedside Póvoa, Pedro Antibiotic stewardship Biomarkers Diagnosis Intensive care unit Sepsis Critical Care and Intensive Care Medicine |
| title_short |
How to use biomarkers of infection or sepsis at the bedside |
| title_full |
How to use biomarkers of infection or sepsis at the bedside |
| title_fullStr |
How to use biomarkers of infection or sepsis at the bedside |
| title_full_unstemmed |
How to use biomarkers of infection or sepsis at the bedside |
| title_sort |
How to use biomarkers of infection or sepsis at the bedside |
| author |
Póvoa, Pedro |
| author_facet |
Póvoa, Pedro Coelho, Luís Dal-Pizzol, Felipe Ferrer, Ricard Huttner, Angela Conway Morris, Andrew Nobre, Vandack Ramirez, Paula Rouze, Anahita Salluh, Jorge Singer, Mervyn Sweeney, Daniel A. Torres, Antoni Waterer, Grant Kalil, Andre C. |
| author_role |
author |
| author2 |
Coelho, Luís Dal-Pizzol, Felipe Ferrer, Ricard Huttner, Angela Conway Morris, Andrew Nobre, Vandack Ramirez, Paula Rouze, Anahita Salluh, Jorge Singer, Mervyn Sweeney, Daniel A. Torres, Antoni Waterer, Grant Kalil, Andre C. |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Póvoa, Pedro Coelho, Luís Dal-Pizzol, Felipe Ferrer, Ricard Huttner, Angela Conway Morris, Andrew Nobre, Vandack Ramirez, Paula Rouze, Anahita Salluh, Jorge Singer, Mervyn Sweeney, Daniel A. Torres, Antoni Waterer, Grant Kalil, Andre C. |
| dc.subject.por.fl_str_mv |
Antibiotic stewardship Biomarkers Diagnosis Intensive care unit Sepsis Critical Care and Intensive Care Medicine |
| topic |
Antibiotic stewardship Biomarkers Diagnosis Intensive care unit Sepsis Critical Care and Intensive Care Medicine |
| description |
Funding This work received an unrestricted grant from GSK Portugal and was supported by Sociedade Portuguesa de Ginecologia (SPG). |
| publishDate |
2023 |
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2023-01-13T22:20:28Z 2023-02 2023-02-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/10362/147554 |
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http://hdl.handle.net/10362/147554 |
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eng |
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eng |
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0342-4642 PURE: 50125976 https://doi.org/10.1007/s00134-022-06956-y |
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