Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis

Bibliographic Details
Main Author: Guerreiro, Catarina Sousa
Publication Date: 2018
Other Authors: Calado, Ângelo, Sousa, Joana, Fonseca, João Eurico
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/37694
Summary: Copyright © 2018 Guerreiro, Calado, Sousa and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritisDietMediterranean dietGut microbiotaGut permeabilityRheumatoid arthritisCopyright © 2018 Guerreiro, Calado, Sousa and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Growing experimental and clinical evidence suggests that a chronic inflammatory response induced by gut dysbiosis can critically contribute to the development of rheumatic diseases, including rheumatoid arthritis (RA). Of interest, an adherence to a Mediterranean diet has been linked to a reduction in mortality and morbidity in patients with inflammatory diseases. Diet and intestinal microbiota are modifying factors that may influence intestinal barrier strength, functional integrity, and permeability regulation. Intestinal microbiota may play a crucial role in RA pathogenesis, but up to now no solid data has clarified a mechanistic relationship between gut microbiota and the development of RA. Nonetheless, microbiota composition in subjects with RA differs from that of controls and this altered microbiome can be partially restored after prescribing disease modifying antirheumatic drugs. High levels of Prevotella copri and similar species are correlated with low levels of microbiota previously associated with immune regulating properties. In addition, some nutrients can alter intestinal permeability and thereby influence the immune response without a known impact on the microbiota. However, critical questions remain to be elucidated, such as the way microbiome fluctuates in relation to diet, and how disease activity may be influenced by changes in diet, microbiota or diet-intestinal microbiota equilibrium.Frontiers MediaRepositório da Universidade de LisboaGuerreiro, Catarina SousaCalado, ÂngeloSousa, JoanaFonseca, João Eurico2019-03-26T14:13:35Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/37694engFront. Med. 5:3492296-858X10.3389/fmed.2018.00349info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:05:38Zoai:repositorio.ulisboa.pt:10451/37694Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:02:26.586066Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis
title Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis
spellingShingle Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis
Guerreiro, Catarina Sousa
Diet
Mediterranean diet
Gut microbiota
Gut permeability
Rheumatoid arthritis
title_short Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis
title_full Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis
title_fullStr Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis
title_full_unstemmed Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis
title_sort Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis
author Guerreiro, Catarina Sousa
author_facet Guerreiro, Catarina Sousa
Calado, Ângelo
Sousa, Joana
Fonseca, João Eurico
author_role author
author2 Calado, Ângelo
Sousa, Joana
Fonseca, João Eurico
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Guerreiro, Catarina Sousa
Calado, Ângelo
Sousa, Joana
Fonseca, João Eurico
dc.subject.por.fl_str_mv Diet
Mediterranean diet
Gut microbiota
Gut permeability
Rheumatoid arthritis
topic Diet
Mediterranean diet
Gut microbiota
Gut permeability
Rheumatoid arthritis
description Copyright © 2018 Guerreiro, Calado, Sousa and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2019-03-26T14:13:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/37694
url http://hdl.handle.net/10451/37694
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front. Med. 5:349
2296-858X
10.3389/fmed.2018.00349
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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