Methotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis: A Prospective Cohort Study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://arca.fiocruz.br/handle/icict/62800 |
Resumo: | Department of Oral Surgery, Pathology and Clinical Dentistry. School of Dentistry. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil. |
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Rezende Oliveira, SicíliaArruda, José Alcides Almeida deCorrêa, Jôice DiasCarvalho, Valessa FlorindoMedeiros, Julliane DutraSchneider, Ayda HenriquesMachado, Caio CavalcanteDuffles, Letícia FernandaFernandes, Gabriel da RochaCalderaro, Débora CerqueiraTaba Júnior, MarioAbreu, Lucas GuimarãesFukada, Sandra YasuyoOliveira, Renê Donizeti RibeiroLouzada-Júnior, PauloCunha, Fernando QueirozSilva, Tarcília Aparecida2024-02-26T19:28:37Z2024-02-26T19:28:37Z2023OLIVEIRA, Sicília Rezende et al. Methotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis: a prospective cohort study. Microorganisms, v. 12, n. 1, p. 1-17, 2023. Doi: http://dx.doi.org/10.3390/microorganisms12010068.2076-2607https://arca.fiocruz.br/handle/icict/62800engMDPI AGMethotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis: A Prospective Cohort Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Oral Surgery, Pathology and Clinical Dentistry. School of Dentistry. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.Department of Oral Surgery, Pathology and Clinical Dentistry. School of Dentistry. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.Department of Dentistry. Pontifical Catholic University. Belo Horizonte, MG, Brazil.Department of Oral and Maxillofacial Surgery and Periodontology. School of Dentistry of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil.Department of Biology. Federal University of Juiz de Fora. Juiz de Fora, MG, Brazil.Department of Pharmacology. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Division of Clinical Immunology. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Department of BioMolecular Sciences. School of Pharmaceutical Science, University of São Paulo. Ribeirão Preto, SP, Brazil.René Rachou Institure. Oswaldo Cruz Fundation. Belo Horizonte, MG, Brazil.Department of Locomotor Apparatus, Faculty of Medicine. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.Department of Oral and Maxillofacial Surgery and Periodontology. School of Dentistry of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil.Department of Child and Adolescent Oral Health. School of Dentistry. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.Department of BioMolecular Sciences. School of Pharmaceutical Science, University of São Paulo. Ribeirão Preto, SP, Brazil.Division of Clinical Immunology. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Division of Clinical Immunology. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Department of Pharmacology. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Department of Oral Surgery, Pathology and Clinical Dentistry. School of Dentistry. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.This study evaluated the changes in the composition of oral-gut microbiota in patients with rheumatoid arthritis (RA) caused by methotrexate (MTX) and non-surgical periodontal treatment (NSPT). Assessments were performed at baseline (T0), 6 months after MTX treatment (T1), and 45 days after NSPT (T2). The composition of the oral and gut microbiota was assessed by amplifying the V4 region of the 16S gene from subgingival plaques and stools. The results of the analysis of continuous variables were presented descriptively and non-parametric tests and Spearman's correlation were adopted. A total of 37 patients (27 with periodontitis) were evaluated at T0; 32 patients (24 with periodontitis) at T1; and 28 patients (17 with periodontitis) at T2. MTX tended to reduce the alpha diversity of the oral-gut microbiota, while NSPT appeared to increase the number of different species of oral microbiota. MTX and NSPT influenced beta diversity in the oral microbiota. The relative abundance of oral microbiota was directly influenced by periodontal status. MTX did not affect the periodontal condition but modified the correlations that varied from weak to moderate (p < 0.05) between clinical parameters and the microbiota. MTX and NSPT directly affected the composition and richness of the oral-gut microbiota. However, MTX did not influence periodontal parameters.gut microbiomemethotrexatemicrobiotamouthperiodontitisrheumatoid arthritisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMethotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis_ A Prospective Cohort Study.pdfMethotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis_ A Prospective Cohort Study.pdfapplication/pdf7786294https://arca.fiocruz.br/bitstreams/41a08b42-2aa9-433c-bf16-d63790556305/downloadf8d09d5f9a3bb6562bb20563fb929d82MD52trueAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/259a8135-e856-4c28-9e0d-b365f7bd8b9e/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADTEXTMethotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis_ A Prospective Cohort Study.pdf.txtMethotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis_ A Prospective Cohort Study.pdf.txtExtracted texttext/plain68876https://arca.fiocruz.br/bitstreams/2c9ad1a4-1ab0-404a-8bea-c90270d1b9d7/download6671f6114cbfbadb895e448b10a16a28MD55falseAnonymousREADTHUMBNAILMethotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis_ A Prospective Cohort Study.pdf.jpgMethotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis_ A Prospective Cohort Study.pdf.jpgGenerated Thumbnailimage/jpeg5887https://arca.fiocruz.br/bitstreams/684e8fbd-5224-4596-b991-f0b89f82f98d/download4a99d5496e7ac5f4aaed337357587442MD56falseAnonymousREADicict/628002025-07-29 20:59:12.421open.accessoai:arca.fiocruz.br:icict/62800https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T23:59:12Repositório Institucional da FIOCRUZ (ARCA) - 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| dc.title.none.fl_str_mv |
Methotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis: A Prospective Cohort Study |
| title |
Methotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis: A Prospective Cohort Study |
| spellingShingle |
Methotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis: A Prospective Cohort Study Rezende Oliveira, Sicília gut microbiome methotrexate microbiota mouth periodontitis rheumatoid arthritis |
| title_short |
Methotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis: A Prospective Cohort Study |
| title_full |
Methotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis: A Prospective Cohort Study |
| title_fullStr |
Methotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis: A Prospective Cohort Study |
| title_full_unstemmed |
Methotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis: A Prospective Cohort Study |
| title_sort |
Methotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis: A Prospective Cohort Study |
| author |
Rezende Oliveira, Sicília |
| author_facet |
Rezende Oliveira, Sicília Arruda, José Alcides Almeida de Corrêa, Jôice Dias Carvalho, Valessa Florindo Medeiros, Julliane Dutra Schneider, Ayda Henriques Machado, Caio Cavalcante Duffles, Letícia Fernanda Fernandes, Gabriel da Rocha Calderaro, Débora Cerqueira Taba Júnior, Mario Abreu, Lucas Guimarães Fukada, Sandra Yasuyo Oliveira, Renê Donizeti Ribeiro Louzada-Júnior, Paulo Cunha, Fernando Queiroz Silva, Tarcília Aparecida |
| author_role |
author |
| author2 |
Arruda, José Alcides Almeida de Corrêa, Jôice Dias Carvalho, Valessa Florindo Medeiros, Julliane Dutra Schneider, Ayda Henriques Machado, Caio Cavalcante Duffles, Letícia Fernanda Fernandes, Gabriel da Rocha Calderaro, Débora Cerqueira Taba Júnior, Mario Abreu, Lucas Guimarães Fukada, Sandra Yasuyo Oliveira, Renê Donizeti Ribeiro Louzada-Júnior, Paulo Cunha, Fernando Queiroz Silva, Tarcília Aparecida |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rezende Oliveira, Sicília Arruda, José Alcides Almeida de Corrêa, Jôice Dias Carvalho, Valessa Florindo Medeiros, Julliane Dutra Schneider, Ayda Henriques Machado, Caio Cavalcante Duffles, Letícia Fernanda Fernandes, Gabriel da Rocha Calderaro, Débora Cerqueira Taba Júnior, Mario Abreu, Lucas Guimarães Fukada, Sandra Yasuyo Oliveira, Renê Donizeti Ribeiro Louzada-Júnior, Paulo Cunha, Fernando Queiroz Silva, Tarcília Aparecida |
| dc.subject.en.none.fl_str_mv |
gut microbiome methotrexate microbiota mouth periodontitis rheumatoid arthritis |
| topic |
gut microbiome methotrexate microbiota mouth periodontitis rheumatoid arthritis |
| description |
Department of Oral Surgery, Pathology and Clinical Dentistry. School of Dentistry. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil. |
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2023 |
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2023 |
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2024-02-26T19:28:37Z |
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2024-02-26T19:28:37Z |
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OLIVEIRA, Sicília Rezende et al. Methotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis: a prospective cohort study. Microorganisms, v. 12, n. 1, p. 1-17, 2023. Doi: http://dx.doi.org/10.3390/microorganisms12010068. |
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https://arca.fiocruz.br/handle/icict/62800 |
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2076-2607 |
| identifier_str_mv |
OLIVEIRA, Sicília Rezende et al. Methotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis: a prospective cohort study. Microorganisms, v. 12, n. 1, p. 1-17, 2023. Doi: http://dx.doi.org/10.3390/microorganisms12010068. 2076-2607 |
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MDPI AG |
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MDPI AG |
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