Development of nanoparticles to target senescent cells

Bibliographic Details
Main Author: Santos, Ricardo Pedro Moreira Martins Casqueiro
Publication Date: 2020
Format: Master thesis
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/10316/94244
Summary: Dissertação de Mestrado em Investigação Biomédica apresentada à Faculdade de Medicina
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spelling Development of nanoparticles to target senescent cellsDesenvolvimento de nanopartículas direccionadas a células senescentesEnvelhecimentoSenescênciaNanoparticulasTriagem de Alto RendimentoSenoterapiasAgingSenescenceNanoparticlesHigh-throughput ScreeningSenotherapyDissertação de Mestrado em Investigação Biomédica apresentada à Faculdade de MedicinaAging can be defined as a progressive decline, with age dependent loss of functions on living systems. Senescence is a cellular response to severe stress and damage, characterized by cell cycle arrest, upregulation of pro-survival pathways and induction of a complex secretory phenotype. Cellular senescence is an age-related process, being argued that the percentage of senescent cells increases with age. Clearance of senescent cells has proven efficiency in reducing senescent effects in several in vivo models, and the use of senolytics as a therapy seems a promising tool to fight aging and age-related diseases. Recent research has identified targetable vulnerabilities of senescent cells that can be exploited by a novel group of drugs, senolytics. Despite successful proofs-of-concept using senolytics, their potential translational application is hampered by their associated toxicities. Here, we created nanoparticles able to release senotherapeutics and eliminate senescent cells. The senolytic activity of the nanoparticles was obtained by high-throughput screening against healthy and senescent cells. Overall, our results open a new therapeutic tool to target senescent cells.H20202020-12-142026-12-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttps://hdl.handle.net/10316/94244https://hdl.handle.net/10316/94244TID:202696600engSantos, Ricardo Pedro Moreira Martins Casqueiroinfo:eu-repo/semantics/embargoedAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-02T16:58:38Zoai:estudogeral.uc.pt:10316/94244Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T05:42:09.261926Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Development of nanoparticles to target senescent cells
Desenvolvimento de nanopartículas direccionadas a células senescentes
title Development of nanoparticles to target senescent cells
spellingShingle Development of nanoparticles to target senescent cells
Santos, Ricardo Pedro Moreira Martins Casqueiro
Envelhecimento
Senescência
Nanoparticulas
Triagem de Alto Rendimento
Senoterapias
Aging
Senescence
Nanoparticles
High-throughput Screening
Senotherapy
title_short Development of nanoparticles to target senescent cells
title_full Development of nanoparticles to target senescent cells
title_fullStr Development of nanoparticles to target senescent cells
title_full_unstemmed Development of nanoparticles to target senescent cells
title_sort Development of nanoparticles to target senescent cells
author Santos, Ricardo Pedro Moreira Martins Casqueiro
author_facet Santos, Ricardo Pedro Moreira Martins Casqueiro
author_role author
dc.contributor.author.fl_str_mv Santos, Ricardo Pedro Moreira Martins Casqueiro
dc.subject.por.fl_str_mv Envelhecimento
Senescência
Nanoparticulas
Triagem de Alto Rendimento
Senoterapias
Aging
Senescence
Nanoparticles
High-throughput Screening
Senotherapy
topic Envelhecimento
Senescência
Nanoparticulas
Triagem de Alto Rendimento
Senoterapias
Aging
Senescence
Nanoparticles
High-throughput Screening
Senotherapy
description Dissertação de Mestrado em Investigação Biomédica apresentada à Faculdade de Medicina
publishDate 2020
dc.date.none.fl_str_mv 2020-12-14
2026-12-13T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10316/94244
https://hdl.handle.net/10316/94244
TID:202696600
url https://hdl.handle.net/10316/94244
identifier_str_mv TID:202696600
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833602443522342912

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