Acute hospitalization in a cohort of patients with systemic sclerosis

Bibliographic Details
Main Author: Caetano, Joana
Publication Date: 2022
Other Authors: Batista, Frederico, Amaral, Marta C., Oliveira, Susana, Alves, José D.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/147439
Summary: Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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spelling Acute hospitalization in a cohort of patients with systemic sclerosisa 10-year retrospective cohort studyHospitalsInfectionsInpatientsOutcome assessmentSystemic sclerodermaImmunology and AllergyRheumatologyImmunologySDG 3 - Good Health and Well-beingPublisher Copyright: © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.This study aimed at analysing the causes and predictors of acute hospitalization and mortality in a cohort of SSc. Retrospective analysis of all acute hospital admissions of SSc patients fulfilling the 2013 EULAR/ACR Classification Criteria, from a single-centre cohort of 95 patients, between 2010 and 2020. The total number of SSc patients registered in our hospital, in this period, was 123. Clinical data were collected from medical files of our institution and from the National Healthcare Registry platform. 53 patients needed acute hospitalization, in a total of 164 admissions. The most frequent causes for admission were: infectious diseases [27%; 70% due to pneumoniae, of which 74% had SSc-associated interstitial lung disease (ILD)], cardiac disease (16.5%), peripheral vascular disease [12.8%; all due to digital ulcers], pulmonary hypertension (PH) (9.8%) and ILD (9.1%). There was an increase in admissions due to cardiac disease over the 10 years of follow-up, and a decrease of ILD over the last 5 years. Fourteen patients died (in-hospital mortality of 9%) mainly due to pneumoniae (36%), heart failure (21%), neoplastic diseases (21%), PH (14%) and ILD (7%). From all the admissions due to infection 70.5% were under immunosuppression at the time of the hospitalization. The frequency of acute admissions superior to 1 was associated with infection (OR 2.29, 95%CI 1.11–4.71). There were several factors associated with both acute admissions and mortality, including: gender, race, digital ulcers, cardiac dysfunction, ILD and PH. Infection was the principal cause of acute hospitalization and mortality, mainly due to pneumoniae. Although a high percentage of those had ILD, it has been decreasing in the last years in our cohort, as a direct cause of hospital admission and mortality, possibly reflecting the advances in its management.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNCaetano, JoanaBatista, FredericoAmaral, Marta C.Oliveira, SusanaAlves, José D.2023-01-12T22:16:53Z2022-082022-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/147439eng0172-8172PURE: 33723084https://doi.org/10.1007/s00296-021-04983-4info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:08:04Zoai:run.unl.pt:10362/147439Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:38:32.308198Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Acute hospitalization in a cohort of patients with systemic sclerosis
a 10-year retrospective cohort study
title Acute hospitalization in a cohort of patients with systemic sclerosis
spellingShingle Acute hospitalization in a cohort of patients with systemic sclerosis
Caetano, Joana
Hospitals
Infections
Inpatients
Outcome assessment
Systemic scleroderma
Immunology and Allergy
Rheumatology
Immunology
SDG 3 - Good Health and Well-being
title_short Acute hospitalization in a cohort of patients with systemic sclerosis
title_full Acute hospitalization in a cohort of patients with systemic sclerosis
title_fullStr Acute hospitalization in a cohort of patients with systemic sclerosis
title_full_unstemmed Acute hospitalization in a cohort of patients with systemic sclerosis
title_sort Acute hospitalization in a cohort of patients with systemic sclerosis
author Caetano, Joana
author_facet Caetano, Joana
Batista, Frederico
Amaral, Marta C.
Oliveira, Susana
Alves, José D.
author_role author
author2 Batista, Frederico
Amaral, Marta C.
Oliveira, Susana
Alves, José D.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Caetano, Joana
Batista, Frederico
Amaral, Marta C.
Oliveira, Susana
Alves, José D.
dc.subject.por.fl_str_mv Hospitals
Infections
Inpatients
Outcome assessment
Systemic scleroderma
Immunology and Allergy
Rheumatology
Immunology
SDG 3 - Good Health and Well-being
topic Hospitals
Infections
Inpatients
Outcome assessment
Systemic scleroderma
Immunology and Allergy
Rheumatology
Immunology
SDG 3 - Good Health and Well-being
description Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
publishDate 2022
dc.date.none.fl_str_mv 2022-08
2022-08-01T00:00:00Z
2023-01-12T22:16:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/147439
url http://hdl.handle.net/10362/147439
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0172-8172
PURE: 33723084
https://doi.org/10.1007/s00296-021-04983-4
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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