Spores of Clostridioides difficile are toxin delivery vehicles

• Main Author: Cassona, Carolina P.
• Publication Date: 2024
• Other Authors: Ramalhete, Sara, Amara, Khira, Candela, Thomas, Kansau, Imad, Denève-Larrazet, Cécile, Janoir-Jouveshomme, Claire, Mota, Luís Jaime, Dupuy, Bruno, Serrano, Mónica, Henriques, Adriano O.
• Format: Article
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: http://hdl.handle.net/10362/182741
• topic: Spores, Bacterial/metabolism; Clostridioides difficile/genetics; Bacterial Toxins/metabolism; Humans; Bacterial Proteins/metabolism; Gene Expression Regulation, Bacterial; Animals; Chlorocebus aethiops; Vero Cells; Enterotoxins/metabolism; Medicine (miscellaneous); Biochemistry, Genetics and Molecular Biology(all); Agricultural and Biological Sciences(all)

Funding Information: We thank Simon Cutting for the gift of the anti-CotD antibody and Aimee Shen for the gift of the anti-GerS and anti-GPR antibodies. We thank Georges Haustant for help with the spore cytopathic assays. This work was supported by grant PEst-OE/EQB/LA0004/2011 from the \u201CFunda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia\u201D (FCT) to A.O.H. This work was also financially supported by Project LISBOA-01-0145-FEDER-007660 (\u201CMicrobiologia Molecular, Estrutural e Celular\u201D) funded by FEDER funds through COMPETE2020 - \u201CPrograma Operacional Competitividade e Internacionaliza\u00E7\u00E3o\u201D (POCI), by national funds through the FCT (\u201CFunda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia\u201D), and by program IF of the FCT (IF/00268/2013/CP1173/CT0006) to M.S. C.C. (PD/BD/52212/2013), S.R. (SFRH/BD/45459/08) and K.A. (PD/BD/148398/2019) were the recipients of doctoral fellowships from the FCT. Publisher Copyright: © The Author(s) 2024.