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Glycosylation in cancer: Mechanisms and clinical implications

Bibliographic Details
Main Author: Pinho, SS
Publication Date: 2015
Other Authors: Reis, CA
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://repositorio-aberto.up.pt/handle/10216/118208
Summary: Despite recent progress in understanding the cancer genome, there is still a relative delay in understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology has been instrumental in relevant discoveries in various biological and medical fields, and has contributed to the deciphering of several human diseases. Glycans are involved in fundamental molecular and cell biology processes occurring in cancer, such as cell signalling and communication, tumour cell dissociation and invasion, cell-matrix interactions, tumour angiogenesis, immune modulation and metastasis formation. The roles of glycans in cancer have been highlighted by the fact that alterations in glycosylation regulate the development and progression of cancer, serving as important biomarkers and providing a set of specific targets for therapeutic intervention. This Review discusses the role of glycans in fundamental mechanisms controlling cancer development and progression, and their applications in oncology.
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spelling Glycosylation in cancer: Mechanisms and clinical implicationsGlycoconjugates/metabolismGlycosylationHumansNeoplasms/diagnosisNeoplasms/immunologyNeoplasms/metabolismNeoplasms/pathologyNeoplasms/therapyPolysaccharides/immunologyPolysaccharides/metabolismDespite recent progress in understanding the cancer genome, there is still a relative delay in understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology has been instrumental in relevant discoveries in various biological and medical fields, and has contributed to the deciphering of several human diseases. Glycans are involved in fundamental molecular and cell biology processes occurring in cancer, such as cell signalling and communication, tumour cell dissociation and invasion, cell-matrix interactions, tumour angiogenesis, immune modulation and metastasis formation. The roles of glycans in cancer have been highlighted by the fact that alterations in glycosylation regulate the development and progression of cancer, serving as important biomarkers and providing a set of specific targets for therapeutic intervention. This Review discusses the role of glycans in fundamental mechanisms controlling cancer development and progression, and their applications in oncology.Nature Publishing Group20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://repositorio-aberto.up.pt/handle/10216/118208eng1474-175X10.1038/nrc3982Pinho, SSReis, CAinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-27T18:36:45Zoai:repositorio-aberto.up.pt:10216/118208Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T22:53:26.393448Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Glycosylation in cancer: Mechanisms and clinical implications
title Glycosylation in cancer: Mechanisms and clinical implications
spellingShingle Glycosylation in cancer: Mechanisms and clinical implications
Pinho, SS
Glycoconjugates/metabolism
Glycosylation
Humans
Neoplasms/diagnosis
Neoplasms/immunology
Neoplasms/metabolism
Neoplasms/pathology
Neoplasms/therapy
Polysaccharides/immunology
Polysaccharides/metabolism
title_short Glycosylation in cancer: Mechanisms and clinical implications
title_full Glycosylation in cancer: Mechanisms and clinical implications
title_fullStr Glycosylation in cancer: Mechanisms and clinical implications
title_full_unstemmed Glycosylation in cancer: Mechanisms and clinical implications
title_sort Glycosylation in cancer: Mechanisms and clinical implications
author Pinho, SS
author_facet Pinho, SS
Reis, CA
author_role author
author2 Reis, CA
author2_role author
dc.contributor.author.fl_str_mv Pinho, SS
Reis, CA
dc.subject.por.fl_str_mv Glycoconjugates/metabolism
Glycosylation
Humans
Neoplasms/diagnosis
Neoplasms/immunology
Neoplasms/metabolism
Neoplasms/pathology
Neoplasms/therapy
Polysaccharides/immunology
Polysaccharides/metabolism
topic Glycoconjugates/metabolism
Glycosylation
Humans
Neoplasms/diagnosis
Neoplasms/immunology
Neoplasms/metabolism
Neoplasms/pathology
Neoplasms/therapy
Polysaccharides/immunology
Polysaccharides/metabolism
description Despite recent progress in understanding the cancer genome, there is still a relative delay in understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology has been instrumental in relevant discoveries in various biological and medical fields, and has contributed to the deciphering of several human diseases. Glycans are involved in fundamental molecular and cell biology processes occurring in cancer, such as cell signalling and communication, tumour cell dissociation and invasion, cell-matrix interactions, tumour angiogenesis, immune modulation and metastasis formation. The roles of glycans in cancer have been highlighted by the fact that alterations in glycosylation regulate the development and progression of cancer, serving as important biomarkers and providing a set of specific targets for therapeutic intervention. This Review discusses the role of glycans in fundamental mechanisms controlling cancer development and progression, and their applications in oncology.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio-aberto.up.pt/handle/10216/118208
url https://repositorio-aberto.up.pt/handle/10216/118208
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1474-175X
10.1038/nrc3982
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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